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| PolysacDB ID | 2507 |
| Carbohydrate Name | Core oligosaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae 01 serogroup (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Purified LPS |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab E8 |
| Antibody type and class | IgG1 |
| Assay System | Enzyme-linked immunosorbent assayinhibition experiments, Coagglutination experiments |
| Cross-reactivity | This Mab cross-reacted with both 0-group 1 vibrios and some non-O-group 1 vibrios |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may provide improved opportunities for the characterization of antigenic determinants |
| Curator ID | AA + AS |
| Date of Curation | 09-06-2011 |
| References | PMC347760 |
| PolysacDB ID | 2508 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae 01 serogroup (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues. |
| BCSDB Structure | 6642 |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Killed Vaccine consisting of V. cholerae O1 Inaba (ATCC 14033) and Ogawa (ATCC 14035) cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A6 |
| Antibody type and class | IgG3 |
| Assay System | Enzyme-linked immunosorbent assay (ELISA), immunofluorescence, Immunoelectron microscopy and the slide agglutination test |
| Cross-reactivity | This Mab reacted with both Inaba and Ogawa serovars (A antigen) and was specific to O1 serotype |
| Proposed epitopes | The epitope was named as Epitope A. Epitope A was postulated to be either the perosamine residues or the N-tetronic acid (N-3-deoxy-L-glycero-tetronic acid) side chain |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab produced discernible agglutination within 1 min with each of the 37 01 whole-cell suspensions tested |
| Curator ID | AA + AS |
| Date of Curation | 10-06-2011 |
| References | PMC266720 |
| PolysacDB ID | 2509 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae 01 serogroup (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues. |
| BCSDB Structure | 6642 |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Killed Vaccine consisting of V. cholerae O1 Inaba (ATCC 14033) and Ogawa (ATCC 14035) cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A12 |
| Antibody type and class | IgG3 |
| Assay System | Enzyme-linked immunosorbent assay (ELISA), immunofluorescence, Immunoelectron microscopy and the slide agglutination test |
| Cross-reactivity | This Mab reacted with both Inaba and Ogawa serovars (A antigen) and was specific to O1 serotype |
| Proposed epitopes | The epitope was named as Epitope A. Epitope A was postulated to be either the perosamine residues or the N-tetronic acid (N-3-deoxy-L-glycero-tetronic acid) side chain |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab produced discernible agglutination within 1 min with each of the 37 01 whole-cell suspensions tested |
| Curator ID | AA + AS |
| Date of Curation | 10-06-2011 |
| References | PMC266720 |
| PolysacDB ID | 2510 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae 01 serogroup (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues. |
| BCSDB Structure | 6642 |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Killed Vaccine consisting of V. cholerae O1 Inaba (ATCC 14033) and Ogawa (ATCC 14035) cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A19 |
| Antibody type and class | IgM |
| Assay System | Enzyme-linked immunosorbent assay (ELISA), immunofluorescence, Immunoelectron microscopy and the slide agglutination test |
| Cross-reactivity | This Mab reacted with both Inaba and Ogawa serovars (A antigen) and was specific to O1 serotype. It however reacted weakly with five V. cholerae non-O1 serovars and Serratia marcescens |
| Proposed epitopes | The epitope was named as Epitope A. Epitope A was postulated to be either the perosamine residues or the N-tetronic acid (N-3-deoxy-L-glycero-tetronic acid) side chain |
| IEDB Epitope | N/A |
| Proposed Utility | The A19 anti-A antigen MAb agglutinated each O1 serovar and Serratia marcescens, albeit weakly |
| Curator ID | AA + AS |
| Date of Curation | 10-06-2011 |
| References | PMC266720 |
| PolysacDB ID | 2511 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae 01 serogroup (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues. |
| BCSDB Structure | 6642 |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Killed Vaccine consisting of V. cholerae O1 Inaba (ATCC 14033) and Ogawa (ATCC 14035) cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A10 |
| Antibody type and class | N/A |
| Assay System | Enzyme-linked immunosorbent assay (ELISA), immunofluorescence, Immunoelectron microscopy and the slide agglutination test |
| Cross-reactivity | This antibody reacted with the Ogawa serovars only (B antigen) |
| Proposed epitopes | The epitope was named as Epitope B |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for the utility to detect cholera vibrios in direct fecal smears |
| Curator ID | AA + AS |
| Date of Curation | 11-06-2011 |
| References | PMC266720 |
| PolysacDB ID | 2512 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae 01 serogroup (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues. |
| BCSDB Structure | 6642 |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Killed Vaccine consisting of V. cholerae O1 Inaba (ATCC 14033) and Ogawa (ATCC 14035) cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A11 |
| Antibody type and class | N/A |
| Assay System | Enzyme-linked immunosorbent assay (ELISA), immunofluorescence, Immunoelectron microscopy and the slide agglutination test |
| Cross-reactivity | This antibody reacted with the Ogawa serovars only (B antigen) |
| Proposed epitopes | The epitope was named as Epitope B |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for the utility to detect cholera vibrios in direct fecal smears |
| Curator ID | AA + AS |
| Date of Curation | 11-06-2011 |
| References | PMC266720 |
| PolysacDB ID | 2513 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae 01 serogroup (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues. |
| BCSDB Structure | 6642 |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Killed Vaccine consisting of V. cholerae O1 Inaba (ATCC 14033) and Ogawa (ATCC 14035) cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A18 |
| Antibody type and class | N/A |
| Assay System | Enzyme-linked immunosorbent assay (ELISA), immunofluorescence, Immunoelectron microscopy and the slide agglutination test |
| Cross-reactivity | This MAb reacted with the Inaba serovars only (C antigen) |
| Proposed epitopes | The epitope was named as Epitope C |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab agglutinated the cells from Inaba serovars |
| Curator ID | AA + AS |
| Date of Curation | 13-06-2011 |
| References | PMC266720 |
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Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036 |