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| PolysacDB ID | 2503 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae serogroup O139 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues. |
| BCSDB Structure | N/A |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Acetone-treated whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab ICL9 |
| Antibody type and class | IgM |
| Assay System | Enzyme-linked immunosorbent assay, slide agglutination test, motility inhibition test, and indirect immunofluorescence test |
| Cross-reactivity | This Mab was specific to V. cholerae O139. No cross-reactions were seen with LPS from V cholerae 01 Inaba and Ogawa serotypes |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | All 86 cases diagnosed as V. cholerae 0139 by a rabbit polyclonal antiserum were also detected by this MAb, establishing its utility as highly sensitive and specific diagnostic reagent |
| Curator ID | AA + AS |
| Date of Curation | 08-06-2011 |
| References | 7496922 |
| PolysacDB ID | 2504 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae serogroup O139 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues. |
| BCSDB Structure | N/A |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Acetone-treated whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab ICL13 |
| Antibody type and class | IgM |
| Assay System | Enzyme-linked immunosorbent assay, slide agglutination test, motility inhibition test, and indirect immunofluorescence test |
| Cross-reactivity | This Mab was specific to V. cholerae O139. No cross-reactions were seen with LPS from V cholerae 01 Inaba and Ogawa serotypes |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | All 86 cases diagnosed as V. cholerae 0139 by a rabbit polyclonal antiserum were also detected by this MAb, establishing its utility as highly sensitive and specific diagnostic reagent |
| Curator ID | AA + AS |
| Date of Curation | 08-06-2011 |
| References | 7496922 |
| PolysacDB ID | 2505 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae serogroup O139 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues. |
| BCSDB Structure | N/A |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Acetone-treated whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab ICL11 |
| Antibody type and class | IgG3 |
| Assay System | Enzyme-linked immunosorbent assay, slide agglutination test, motility inhibition test, and indirect immunofluorescence test |
| Cross-reactivity | This Mab was specific to V. cholerae O139. No cross-reactions were seen with LPS from V cholerae 01 Inaba and Ogawa serotypes |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | All 86 cases diagnosed as V. cholerae 0139 by a rabbit polyclonal antiserum were also detected by this MAb, establishing its utility as highly sensitive and specific diagnostic reagent |
| Curator ID | AA + AS |
| Date of Curation | 08-06-2011 |
| References | 7496922 |
| PolysacDB ID | 2506 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae serogroup O139 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues. |
| BCSDB Structure | N/A |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Acetone-treated whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab ICL12 |
| Antibody type and class | IgG2b |
| Assay System | Enzyme-linked immunosorbent assay, slide agglutination test, motility inhibition test, and indirect immunofluorescence test |
| Cross-reactivity | This Mab was specific to V. cholerae O139. No cross-reactions were seen with LPS from V cholerae 01 Inaba and Ogawa serotypes |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | All 86 cases diagnosed as V. cholerae 0139 by a rabbit polyclonal antiserum were also detected by this MAb, establishing its utility as highly sensitive and specific diagnostic reagent |
| Curator ID | AA + AS |
| Date of Curation | 09-06-2011 |
| References | 7496922 |
| PolysacDB ID | 2554 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae serogroup O139 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Whole cell lysates |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 12F5-G11 |
| Antibody type and class | IgG2b |
| Assay System | Dot-blot ELISA, immunoblotting, ELISA |
| Cross-reactivity | This Mab was specific to Vibrio cholerae serogroup O139 and did not cross-react with 137 strains of other enteric microorganisms |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used as a detection reagent in the antigen detection assay for diagnosis of cholera caused by V. cholerae O139 |
| Curator ID | AA + AS |
| Date of Curation | 25-06-2011 |
| References | 9817879 |
| PolysacDB ID | 2555 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae serogroup O139 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Whole cell lysates |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 12F5-G2 |
| Antibody type and class | IgG2b |
| Assay System | Dot-blot ELISA, immunoblotting, ELISA |
| Cross-reactivity | This Mab was specific to Vibrio cholerae serogroup O139 and did not cross-react with 137 strains of other enteric microorganisms |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used as a detection reagent in the antigen detection assay for diagnosis of cholera caused by V. cholerae O139 |
| Curator ID | AA + AS |
| Date of Curation | 25-06-2011 |
| References | 9817879 |
| PolysacDB ID | 2556 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae serogroup O139 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Whole cell lysates |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 15F5-H5 |
| Antibody type and class | IgG2b |
| Assay System | Dot-blot ELISA, immunoblotting, ELISA |
| Cross-reactivity | This Mab was specific to Vibrio cholerae serogroup O139 and did not cross-react with 137 strains of other enteric microorganisms |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used as a detection reagent in the antigen detection assay for diagnosis of cholera caused by V. cholerae O139 |
| Curator ID | AA + AS |
| Date of Curation | 25-06-2011 |
| References | 9817879 |
| PolysacDB ID | 2557 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae serogroup O139 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Whole cell lysates |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 5B9-F8 |
| Antibody type and class | IgM |
| Assay System | Dot-blot ELISA, immunoblotting, ELISA |
| Cross-reactivity | This Mab was specific to Vibrio cholerae serogroup O139 and did not cross-react with 137 strains of other enteric microorganisms |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used as a detection reagent in the antigen detection assay for diagnosis of cholera caused by V. cholerae O139 |
| Curator ID | AA + AS |
| Date of Curation | 25-06-2011 |
| References | 9817879 |
| PolysacDB ID | 2558 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae serogroup O139 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Whole cell lysates |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 14C9-D2 |
| Antibody type and class | IgG2b |
| Assay System | Dot-blot ELISA, immunoblotting, ELISA |
| Cross-reactivity | This Mab was specific to Vibrio cholerae serogroup O139 and did not cross-react with 137 strains of other enteric microorganisms |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used as a detection reagent in the antigen detection assay for diagnosis of cholera caused by V. cholerae O139 |
| Curator ID | AA + AS |
| Date of Curation | 26-06-2011 |
| References | 9817879 |
| PolysacDB ID | 2559 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae serogroup O139 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Whole cell lysates |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 6D2-D8 |
| Antibody type and class | IgG3 |
| Assay System | Dot-blot ELISA, immunoblotting, ELISA |
| Cross-reactivity | This Mab was specific to Vibrio cholerae serogroup O139 and did not cross-react with 137 strains of other enteric microorganisms |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used as a detection reagent in the antigen detection assay for diagnosis of cholera caused by V. cholerae O139 |
| Curator ID | AA + AS |
| Date of Curation | 27-06-2011 |
| References | 9817879 |
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Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036 |