PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
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PolysacDB ID2644
Carbohydrate NameGlucurunoxylomannan   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
Microbe NameCryptococcus neoformans Serotype A [strain 24064]   (NCBI Taxonomy)   (Drugpedia)
Basic StructureA linear α(1-->3)- linked mannan backbone singly substituted with non-reducing β(1-->2) xylose and β(1-->2) glucuronic acid side branches ; O-acetyl groups are present at C-6 of the mannosyl residues
BCSDB StructureN/A
Proposed FunctionAntiphagocytic ; an important virulence factor
Antigenic NatureGlycoconjugates
Carrier NameRBC
Conjugate MethodN/A
AntibodiesMab 383
Antibody Type ClassN/A
Assay SystemELISA and Dot enzyme assay
Cross ReactivityThis antibody cross-reacted to all 4 serotypes of Cryptococcus neoformans
Proposed EpitopeN/A
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation31-07-2011
ReferencesPMC176118

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PolysacDB ID2645
Carbohydrate NameGlucurunoxylomannan   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
Microbe NameCryptococcus neoformans Serotype C [strain 24066]   (NCBI Taxonomy)   (Drugpedia)
Basic StructureA linear α(1-->3)- linked mannan backbone singly substituted with non-reducing β(1-->2) xylose and β(1-->2) glucuronic acid side branches ; O-acetyl groups are present at C-6 of the mannosyl residues
BCSDB StructureN/A
Proposed FunctionAntiphagocytic ; an important virulence factor
Antigenic NatureGlycoconjugates
Carrier NameRBC
Conjugate MethodN/A
AntibodiesMab 2D4
Antibody Type ClassN/A
Assay SystemELISA and Dot enzyme assay
Cross ReactivityThis antibody cross-reacted with Serotypes A, B and C
Proposed EpitopeN/A
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation31-07-2011
ReferencesPMC176118

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