PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
   
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PolysacDB ID1007
Carbohydrate NameLipoarabinomannan   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium tuberculosis   (NCBI Taxonomy)   (Drugpedia)
Basic StructureMycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure127448
Proposed FunctionT cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic NatureHeat killed Mycobacterium tuberculosis
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 5c11
Antibody Type ClassIgM
Assay SystemIndirect immunofluorescence, ELISA, western blotting
Cross ReactivityThis antibody cross-reacted with large number of mycobacterial species.
Proposed EpitopeArabinose moiety of Lipoarabinomannan
IEDB EpitopeN/A
Proposed UtilityThis antibody has been used in the detection of mycobacteria in clinical samples
Curator IDAA + AS
Date of Curation02-01-2010
ReferencesPMC229406

Record - 2 of 1335   [TOP]

PolysacDB ID1008
Carbohydrate NameMycolyl-arabinogalactan-peptidoglycan complex   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium tuberculosis   (NCBI Taxonomy)   (Drugpedia)
Basic StructureMycolyl-arabinogalactan-peptidoglycan complex is the fraction of the mycobacterial cell wall left after removing all soluble carbohydrates, proteins and lipids
BCSDB StructureN/A
Proposed FunctionContains lipoarabinomannan as well as arabinose that are important virulence factors
Antigenic NatureHeat killed Mycobacterium tuberculosis
Carrier NameNil
Conjugate MethodNil
AntibodiesMabs 4f11
Antibody Type ClassIgM
Assay SystemIndirect immunofluorescence, ELISA, western blotting
Cross ReactivityThis antibody cross-reacted with large number of mycobacterial species.
Proposed EpitopeArabinose moiety of Lipoarabinomannan
IEDB EpitopeN/A
Proposed UtilityThis antibody has been used in the detection of mycobacteria in clinical samples
Curator IDAA + AS
Date of Curation02-01-2010
ReferencesPMC229406

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PolysacDB ID1009
Carbohydrate NameUnknown carbohydrate   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium tuberculosis   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureHeat killed Mycobacterium tuberculosis
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 9d8
Antibody Type ClassIgG3
Assay SystemIndirect immunofluorescence, ELISA, western blotting
Cross ReactivityThis antibody cross-reacted with M.gordonae, M. gastri, and M. Kansasii
Proposed EpitopeN\A
IEDB EpitopeN/A
Proposed UtilityThis antibody has been used in the detection of mycobacteria in clinical samples
Curator IDAA + AS
Date of Curation03-01-2010
ReferencesPMC229406

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PolysacDB ID1010
Carbohydrate NameLipoarabinomannan   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium tuberculosis   (NCBI Taxonomy)   (Drugpedia)
Basic StructureMycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure127448
Proposed FunctionReported to suppress T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages. Other reported effects include inhibition of protein kinases, inhibition of the synthesis of mRNA encoding IL-2, IL-5, and granulocyte-macrophage colony stimulating factor (GM-CSF) in human T cells and activation of the complement cascade
Antigenic NatureHeat killed Mycobacterium tuberculosis
Carrier NameNil
Conjugate MethodNil
AntibodiesSMITB14
Antibody Type ClassIgG1
Assay SystemN\A
Cross ReactivitySMITB14 bound to whole M. tuberculosis bacteria (H37Rv and Harlingen strains) as well as to the attenuated BCG, but not to other species such as Escherichia coli strains of various O serotypes, Streptococcus pneumoniae isolates, strains of Salmonella, Yersinia enterocolitica and Y. pseudotuberculosis and Nocardia sp.
Proposed EpitopeArabinomannan portion of the antigen
IEDB EpitopeN/A
Proposed UtilityThis antibody might be involved in blocking of mycobacterial invasion. SMITB14 may prevent the uptake of M. tuberculosis through receptor(s) that facilitate bacterial survival and growth.
Curator IDAA + AS
Date of Curation03-01-2010
ReferencesPMC1809178

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PolysacDB ID1011
Carbohydrate NameLipoarabinomannan   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium tuberculosis   (NCBI Taxonomy)   (Drugpedia)
Basic StructureMycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure127448
Proposed FunctionReported to suppress T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages. Other reported effects include inhibition of protein kinases, inhibition of the synthesis of mRNA encoding IL-2, IL-5, and granulocyte-macrophage colony stimulating factor (GM-CSF) in human T cells and activation of the complement cascade
Antigenic NatureHeat killed Mycobacterium tuberculosis
Carrier NameNil
Conjugate MethodNil
AntibodiesMab lam701
Antibody Type ClassIgG3
Assay SystemSandwich ELISA
Cross ReactivityThis antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
Proposed EpitopeN\A
IEDB EpitopeN/A
Proposed UtilityThese antibodies could be used to detect mycobacterial antigens in sputum
Curator IDAA + AS
Date of Curation03-01-2010
References2127645

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PolysacDB ID1032
Carbohydrate NameLipoarabinomannan   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureMycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure127448
Proposed FunctionT cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic NatureWhole killed mycobacteria leprae cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab lam038
Antibody Type ClassIgM
Assay SystemSandwich ELISA
Cross ReactivityThis antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
Proposed EpitopeN\A
IEDB EpitopeN/A
Proposed UtilityThese antibodies could be used to detect mycobacterial antigens in sputum
Curator IDAA + AS
Date of Curation09-01-2010
References2127645

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PolysacDB ID1033
Carbohydrate NameLipoarabinomannan   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureMycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure127448
Proposed FunctionT cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic NatureWhole killed mycobacteria leprae cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab lam204
Antibody Type ClassIgM
Assay SystemSandwich ELISA
Cross ReactivityThis antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
Proposed EpitopeN\A
IEDB EpitopeN/A
Proposed UtilityThese antibodies could be used to detect mycobacterial antigens in sputum
Curator IDAA + AS
Date of Curation09-01-2010
References2127645

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PolysacDB ID1035
Carbohydrate NameLipoarabinomannan   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureMycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure127448
Proposed FunctionT cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic NatureWhole killed mycobacteria leprae cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab lam603
Antibody Type ClassIgM
Assay SystemSandwich ELISA
Cross ReactivityThis antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
Proposed EpitopeN\A
IEDB EpitopeN/A
Proposed UtilityThese antibodies could be used to detect mycobacterial antigens in sputum
Curator IDAA + AS
Date of Curation09-01-2010
References2127645

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PolysacDB ID1036
Carbohydrate NameLipoarabinomannan   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureMycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure127448
Proposed FunctionT cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic NatureWhole killed mycobacteria leprae cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab Cs-35
Antibody Type ClassIgM
Assay SystemIndirect and Competitive ELISA
Cross ReactivityThis antibody cross-reacted to M. tuberculosis and other Mycobacterium speices.
Proposed Epitopeβ-D-Araf- (1-->2)-α-D-Araf-(1-->5)-α- D-Araf-(1-->5)-α-D-Araf within the branched hexa-Araf motif of mycobacterial arabinans
IEDB Epitope76797
Proposed UtilityThese antibodies could be used for screening of cell-wall mutants of mycobacteria lacking AG and AraLAM motifs and the recognition of biosynthetic intermediates of cell-wall polysaccharides unique to mycobacteria.
Curator IDAA + AS
Date of Curation10-01-2010
References12368438

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PolysacDB ID1038
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameRhizobium leguminosarum   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPS is composed of three parts: (1) lipid A, (2) core polysaccharide, and (3) O antigen. The lipid A region contains two glucosamine sugar derivatives, each with three fatty acids and phosphate or pyrophosphate attached. The core polysaccharide has KDO and attached to lipid A. The side chain O is small polysaccharide chain extending outward from the core, it has several peculiar sugars and varies in composition between bacterial strains.
BCSDB Structure1686
Proposed FunctionLPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
Antigenic NatureMixture of suspension of cell envelop.
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 3
Antibody Type ClassN\A
Assay SystemWestern blotting, spot imunoassays, agglutination tests
Cross ReactivityThis antibody was cross-reactive with different strains of R.leguminosarum like R.biovars viciae, trifolli and phaseoli.
Proposed EpitopeN/A
IEDB EpitopeN/A
Proposed UtilityN\A
Curator IDAA + AS
Date of Curation10-01-2010
ReferencesPMC209711

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PolysacDB ID1040
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameChlamydia spp.   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPS is composed of three parts: (1) lipid A, (2) core polysaccharide, and (3) O antigen. The lipid A region contains two glucosamine sugar derivatives, each with three fatty acids and phosphate or pyrophosphate attached. The core polysaccharide has KDO and attached to lipid A. The side chain O is small polysaccharide chain extending outward from the core, it has several peculiar sugars and varies in composition between bacterial strains.
BCSDB Structure116693
Proposed FunctionLPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
Antigenic NatureFormalin killed L2 EBs
Carrier NameNil
Conjugate MethodNil
AntibodiesMab L21-6
Antibody Type ClassIgG3
Assay SystemImmunobloting
Cross ReactivityThis antibody was cross-reactive with Re LPS of S.typhimurium.
Proposed EpitopeN/A
IEDB EpitopeN/A
Proposed UtilityMonoclonal antibody L21-6 recognizes chlamydal genus specific epitope.
Curator IDAA + AS
Date of Curation12-01-2010
ReferencesPMC263518

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PolysacDB ID1041
Carbohydrate NamePhosphocholine   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
Microbe NamePneumococcal strain WU(12)   (NCBI Taxonomy)   (Drugpedia)
Basic StructurePhosphocholine (PC) is an intermediate in the synthesis of phosphatidylcholine in tissues. Phosphocholine is made in a reaction, catalyzed by choline kinase, that converts ATP + Choline into Phosphocholine and ADP
BCSDB StructureN/A
Proposed FunctionPhosphocholine is determinant of lipotechoic acids of Gram positive bacteria
Antigenic NatureCell extract and heat killed Pneumococcal strain EF3296.
Carrier NameNil
Conjugate MethodNil
AntibodiesSR4W1
Antibody Type ClassIgG2a
Assay SystemBlood bactericidal assay, hemolytic activity
Cross ReactivityN/A
Proposed EpitopePhosphocholine
IEDB EpitopeN/A
Proposed UtilityMonoclonal antibody SR4W1 can protect mice against Pneumococcal infections.
Curator IDAA + AS
Date of Curation12-01-2010
ReferencesPMC313299

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PolysacDB ID1042
Carbohydrate NameGlucan   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
Microbe NameNeurospora crassa   (NCBI Taxonomy)   (Drugpedia)
Basic StructureGlucans are a heterogeneous group of glucose polymers, consisting of a backbone of β(1-->3)-linked β-D-glucopyranosyl units with β(1-->6)-linked side chains of varying distribution and length
BCSDB StructureN/A
Proposed FunctionActivates leukocytes, stimulating their phagocytic, cytotoxic, and antimicrobial activities, including the production of reactive oxygen and nitrogen intermediates
Antigenic NatureHomogenous suspension of hyphal walls.
Carrier NameNil
Conjugate MethodNil
AntibodiesS4D1
Antibody Type ClassIgM
Assay SystemELISA, immunofluorescence
Cross ReactivityThis antibody was cross-reactive with A.nidulans, Schiz.commune.
Proposed Epitope1,3-α-glucan
IEDB EpitopeN/A
Proposed UtilityScreening of fungi for presence of 1,3-α-glucan in hyphae cell wall.
Curator IDAA + AS
Date of Curation13-01-2010
References9245814

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PolysacDB ID1045
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameSalmonella typhimurium SR-11   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPS is composed of three parts: (1) lipid A, (2) core polysaccharide, and (3) O antigen. The lipid A region contains two glucosamine sugar derivatives, each with three fatty acids and phosphate or pyrophosphate attached. The core polysaccharide has KDO and attached to lipid A. The side chain O is small polysaccharide chain extending outward from the core, it has several peculiar sugars and varies in composition between bacterial strains.
BCSDB StructureN/A
Proposed FunctionLPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
Antigenic NatureLive S.typhimurium SR cells.
Carrier NameNil
Conjugate MethodNil
AntibodiesST-1
Antibody Type ClassIgM
Assay SystemELISA Hemaggluttination assay
Cross ReactivityThis antibody was cross-reactive with Salmonella typhimurium LT-2, Salmonella typhimurium derby.
Proposed EpitopeO-polysaccharide
IEDB EpitopeN/A
Proposed UtilityThis antibody can be used in serological assays to detect the desired antigen.
Curator IDAA + AS
Date of Curation13-01-2010
References6203984

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PolysacDB ID1046
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameSalmonella typhimurium SR-11   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPS is composed of three parts: (1) lipid A, (2) core polysaccharide, and (3) O antigen. The lipid A region contains two glucosamine sugar derivatives, each with three fatty acids and phosphate or pyrophosphate attached. The core polysaccharide has KDO and attached to lipid A. The side chain O is small polysaccharide chain extending outward from the core, it has several peculiar sugars and varies in composition between bacterial strains.
BCSDB StructureN/A
Proposed FunctionLPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
Antigenic NatureLive S.typhimurium SR cells.
Carrier NameNil
Conjugate MethodNil
AntibodiesPolysera
Antibody Type ClassIgG
Assay SystemELISA Hemaggluttination assay
Cross ReactivityThis antibody was cross-reactive with Salmonella typhimurium LT-2, Salmonella typhimurium derby. Salmonella typhimurium dublin, Salmonella enteritidis and Salmonella paratyphi A.
Proposed EpitopeO-polysaccharide
IEDB EpitopeN/A
Proposed UtilityThis antibody can be used in serological assays to detect the desired antigen.
Curator IDAA + AS
Date of Curation14-01-2010
References6203984

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PolysacDB ID1047
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameEscherichia coli strain J5 (chemotype Rc)   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureWhole cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 7
Antibody Type ClassIgG3
Assay SystemELISA, Limulus assay, invivo protection assay
Cross ReactivityThis antibody was specific to E. coli J5
Proposed EpitopeTerminal glucose residues
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation14-01-2010
References2455054

Record - 17 of 1335   [TOP]

PolysacDB ID1048
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameEscherichia coli strain J5 (chemotype Rc)   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureWhole cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 10
Antibody Type ClassIgG3
Assay SystemELISA, Limulus assay, invivo protection assay
Cross ReactivityThis antibody was specific to E. coli J5
Proposed EpitopeTerminal glucose residues
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation15-01-2010
References2455054

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PolysacDB ID1049
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameEscherichia coli strain J5 (chemotype Rc)   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureWhole cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 2
Antibody Type ClassIgG1
Assay SystemELISA, Limulus assay, invivo protection assay
Cross ReactivityThis antibody ross-reacted with Salmonella minnesota strain R5
Proposed EpitopeTerminal glucose residues
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation15-01-2010
References2455054

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PolysacDB ID1050
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameEscherichia coli strain J5 (chemotype Rc)   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureWhole cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 4
Antibody Type ClassIgG2a
Assay SystemELISA, Limulus assay, invivo protection assay
Cross ReactivityThis antibody ross-reacted with Salmonella minnesota strain R5
Proposed EpitopeTerminal glucose residues
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation16-01-2010
References2455054

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PolysacDB ID1051
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameEscherichia coli strain J5 (chemotype Rc)   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureWhole cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 5
Antibody Type ClassIgG1
Assay SystemELISA, Limulus assay, invivo protection assay
Cross ReactivityThis antibody ross-reacted with Salmonella minnesota strain R5
Proposed EpitopeTerminal glucose residues
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation16-01-2010
References2455054

Record - 21 of 1335   [TOP]

PolysacDB ID1052
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameEscherichia coli strain J5 (chemotype Rc)   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureWhole cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 3
Antibody Type ClassIgG3
Assay SystemELISA, Limulus assay, invivo protection assay
Cross ReactivityThis antibody ross-reacted with Salmonella minnesota strain R5
Proposed EpitopeTerminal glucose residues
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation16-01-2010
References2455054

Record - 22 of 1335   [TOP]

PolysacDB ID1053
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameEscherichia coli strain J5 (chemotype Rc)   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureWhole cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 11
Antibody Type ClassIgG3
Assay SystemELISA, Limulus assay, invivo protection assay
Cross ReactivityThis antibody ross-reacted with Salmonella minnesota strain R5
Proposed EpitopeTerminal glucose residues
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation16-01-2010
References2455054

Record - 23 of 1335   [TOP]

PolysacDB ID1054
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameEscherichia coli strain J5 (chemotype Rc)   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureWhole cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 8
Antibody Type ClassIgG3
Assay SystemELISA, Limulus assay, invivo protection assay
Cross ReactivityThis antibody ross-reacted with Salmonella minnesota strain R5
Proposed EpitopeTerminal glucose residues
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation16-01-2010
References2455054

Record - 24 of 1335   [TOP]

PolysacDB ID1055
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameEscherichia coli strain J5 (chemotype Rc)   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureWhole cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 9
Antibody Type ClassIgG3
Assay SystemELISA, Limulus assay, invivo protection assay
Cross ReactivityThis antibody ross-reacted with Salmonella minnesota strain R5
Proposed EpitopeTerminal glucose residues
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation16-01-2010
References2455054

Record - 25 of 1335   [TOP]

PolysacDB ID1056
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
Microbe NameEscherichia coli strain J5 (chemotype Rc)   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureWhole cells
Carrier NameNil
Conjugate MethodNil
AntibodiesMab 13
Antibody Type ClassIgG3
Assay SystemELISA, Limulus assay, invivo protection assay
Cross ReactivityThis antibody ross-reacted with Salmonella minnesota strain R5
Proposed EpitopeTerminal glucose residues
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation16-01-2010
References2455054

Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036