| PolysacDB ID | 2489 |
| Carbohydrate Name | 35 and 50 KDa surface glycoconjugates (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe Name | Trypanosoma cruzi strain G (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A
|
| BCSDB Structure | N/A |
| Proposed Function | These glycoconjugates may play an important role in the metacyclic form-host cell association that initiates T. cruzi infection |
| Antigenic Nature | Killed strain G metacyclic forms |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 10D8 |
| Antibody Type Class | N/A |
| Assay System | ELISA, immunoblotiing, parasite invasion assay |
| Cross Reactivity | 10D8 was found to react with metacyclic trypomastigotes from triatomine or from culture as well as with epimastigotes but not with tissue amastigotes or blood trypomastigotes |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | The invasion of Vero cells by metacyclic forms of strains Tulahuen and G was inhibited 50 to 67% in the presence of 10D8. Mice that had passively received 10D8 before challenge with metacyclic forms, a considerable decrease in the parasitemia levels was observed |
| Curator ID | AA + AS |
| Date of Curation | 02-06-2011
|
| References | PMC313336 |