| PolysacDB ID | 1027 |
| Carbohydrate Name | Capsular polysaccharide D (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Cryptococcus neoformans (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated
|
| BCSDB Structure | N/A |
| Proposed Function | The capsular polysaccharide is an important virulence factor |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Sheep erythrocytes |
| Conjugate Method | The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature |
| Antibodies | Mab 302 |
| Antibody Type Class | IgG1 |
| Assay System | Ouchterlony double immunodiffusion, Phagocytosis assays |
| Cross Reactivity | This antibody cross-reacted with 2 serotypes- A and D |
| Proposed Epitope | The reactivity of this antibody required acetylation of the parent polysaccharide. Hence proposed epitopes may be O-acetyl groups |
| IEDB Epitope | N/A |
| Proposed Utility | MAb against an epitope shared by all four serotypes may have value for the detection of cryptococcal antigens in body fluids. This antibody also has potent opsonic activity |
| Curator ID | AA + AS |
| Date of Curation | 08-01-2010
|
| References | PMC260621 |