| PolysacDB ID | 1039 |
| Carbohydrate Name | Capsular polysaccharides K5 (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Escherichia coli (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Capsular polysacchirides K5 is disaccharide with repeating unit 4-β-GlcUA(1-->4)-α-GlcNAc
|
| BCSDB Structure | N/A |
| Proposed Function | Capsular polysaccharides are responsible for pathogen`s virulence |
| Antigenic Nature | Whole formalinized E.coli cells. |
| Carrier Name | N/A |
| Conjugate Method | N/A |
| Antibodies | Mab 865 |
| Antibody Type Class | IgM |
| Assay System | Indirect ELISA, Immunoblot analysis |
| Cross Reactivity | This antibody was cross-reactive with ECA of E.coli and S.typhimurium strains. |
| Proposed Epitope | 4-β-GlcUA(1-->4)-α-GlcNAc |
| IEDB Epitope | N/A |
| Proposed Utility | Reaction pattern of Mab with whole cell bacteria indicate that ECA and outer core in encapsulated bacteria are not readily accessible to antibodies.This suggests that these common envelop structures may not be useful antigens for vaccine development. |
| Curator ID | AA + AS |
| Date of Curation | 11-01-2010
|
| References | PMC261975 |