PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
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PolysacDB ID1263
Carbohydrate NameGlucomannoprotein   (Drugpedia)
Carbohydrate ClassGlycoprotein
Microbe NameCandida albicans serotype A   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureGlucomannoprotein-rich antigenic extract (GMP)
Carrier NameNil
Conjugate MethodNil
AntibodiesMab AF-1
Antibody Type ClassIgM
Assay SystemELISA, immunofluorescence and slide agglutination tests
Cross ReactivityThis Mab cross-reacted with C. albicans serotypes A and B, C. tropicalis, C. guilliermondii and C. viswanathii, but did not cross-react with C. krusei, C. parapsilosis, C. kefyr (pseudotropicalis) and T. Glabrata
Proposed EpitopeThe epitope was proposed to consist of mannan residues
IEDB EpitopeN/A
Proposed UtilityThis Mab had strong agglutination properties for Candida species. This Mab helped in the identification of new polysaccharide epitopes on the cell wall of pathogenic Candida species.
Curator IDAA + AS
Date of Curation02-05-2010
References2462051

Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036