PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613

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PolysacDB ID	1007
Carbohydrate Name	Lipoarabinomannan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium tuberculosis (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure	127448
Proposed Function	T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic Nature	Heat killed Mycobacterium tuberculosis
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 5c11
Antibody Type Class	IgM
Assay System	Indirect immunofluorescence, ELISA, western blotting
Cross Reactivity	This antibody cross-reacted with large number of mycobacterial species.
Proposed Epitope	Arabinose moiety of Lipoarabinomannan
IEDB Epitope	N/A
Proposed Utility	This antibody has been used in the detection of mycobacteria in clinical samples
Curator ID	AA + AS
Date of Curation	02-01-2010
References	PMC229406

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PolysacDB ID	1008
Carbohydrate Name	Mycolyl-arabinogalactan-peptidoglycan complex (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium tuberculosis (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycolyl-arabinogalactan-peptidoglycan complex is the fraction of the mycobacterial cell wall left after removing all soluble carbohydrates, proteins and lipids
BCSDB Structure	N/A
Proposed Function	Contains lipoarabinomannan as well as arabinose that are important virulence factors
Antigenic Nature	Heat killed Mycobacterium tuberculosis
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mabs 4f11
Antibody Type Class	IgM
Assay System	Indirect immunofluorescence, ELISA, western blotting
Cross Reactivity	This antibody cross-reacted with large number of mycobacterial species.
Proposed Epitope	Arabinose moiety of Lipoarabinomannan
IEDB Epitope	N/A
Proposed Utility	This antibody has been used in the detection of mycobacteria in clinical samples
Curator ID	AA + AS
Date of Curation	02-01-2010
References	PMC229406

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PolysacDB ID	1009
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium tuberculosis (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Heat killed Mycobacterium tuberculosis
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 9d8
Antibody Type Class	IgG3
Assay System	Indirect immunofluorescence, ELISA, western blotting
Cross Reactivity	This antibody cross-reacted with M.gordonae, M. gastri, and M. Kansasii
Proposed Epitope	N\A
IEDB Epitope	N/A
Proposed Utility	This antibody has been used in the detection of mycobacteria in clinical samples
Curator ID	AA + AS
Date of Curation	03-01-2010
References	PMC229406

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PolysacDB ID	1010
Carbohydrate Name	Lipoarabinomannan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium tuberculosis (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure	127448
Proposed Function	Reported to suppress T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages. Other reported effects include inhibition of protein kinases, inhibition of the synthesis of mRNA encoding IL-2, IL-5, and granulocyte-macrophage colony stimulating factor (GM-CSF) in human T cells and activation of the complement cascade
Antigenic Nature	Heat killed Mycobacterium tuberculosis
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	SMITB14
Antibody Type Class	IgG1
Assay System	N\A
Cross Reactivity	SMITB14 bound to whole M. tuberculosis bacteria (H37Rv and Harlingen strains) as well as to the attenuated BCG, but not to other species such as Escherichia coli strains of various O serotypes, Streptococcus pneumoniae isolates, strains of Salmonella, Yersinia enterocolitica and Y. pseudotuberculosis and Nocardia sp.
Proposed Epitope	Arabinomannan portion of the antigen
IEDB Epitope	N/A
Proposed Utility	This antibody might be involved in blocking of mycobacterial invasion. SMITB14 may prevent the uptake of M. tuberculosis through receptor(s) that facilitate bacterial survival and growth.
Curator ID	AA + AS
Date of Curation	03-01-2010
References	PMC1809178

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PolysacDB ID	1011
Carbohydrate Name	Lipoarabinomannan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium tuberculosis (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure	127448
Proposed Function	Reported to suppress T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages. Other reported effects include inhibition of protein kinases, inhibition of the synthesis of mRNA encoding IL-2, IL-5, and granulocyte-macrophage colony stimulating factor (GM-CSF) in human T cells and activation of the complement cascade
Antigenic Nature	Heat killed Mycobacterium tuberculosis
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab lam701
Antibody Type Class	IgG3
Assay System	Sandwich ELISA
Cross Reactivity	This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
Proposed Epitope	N\A
IEDB Epitope	N/A
Proposed Utility	These antibodies could be used to detect mycobacterial antigens in sputum
Curator ID	AA + AS
Date of Curation	03-01-2010
References	2127645

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PolysacDB ID	1032
Carbohydrate Name	Lipoarabinomannan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium leprae (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure	127448
Proposed Function	T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic Nature	Whole killed mycobacteria leprae cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab lam038
Antibody Type Class	IgM
Assay System	Sandwich ELISA
Cross Reactivity	This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
Proposed Epitope	N\A
IEDB Epitope	N/A
Proposed Utility	These antibodies could be used to detect mycobacterial antigens in sputum
Curator ID	AA + AS
Date of Curation	09-01-2010
References	2127645

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PolysacDB ID	1033
Carbohydrate Name	Lipoarabinomannan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium leprae (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure	127448
Proposed Function	T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic Nature	Whole killed mycobacteria leprae cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab lam204
Antibody Type Class	IgM
Assay System	Sandwich ELISA
Cross Reactivity	This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
Proposed Epitope	N\A
IEDB Epitope	N/A
Proposed Utility	These antibodies could be used to detect mycobacterial antigens in sputum
Curator ID	AA + AS
Date of Curation	09-01-2010
References	2127645

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PolysacDB ID	1035
Carbohydrate Name	Lipoarabinomannan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium leprae (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure	127448
Proposed Function	T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic Nature	Whole killed mycobacteria leprae cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab lam603
Antibody Type Class	IgM
Assay System	Sandwich ELISA
Cross Reactivity	This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
Proposed Epitope	N\A
IEDB Epitope	N/A
Proposed Utility	These antibodies could be used to detect mycobacterial antigens in sputum
Curator ID	AA + AS
Date of Curation	09-01-2010
References	2127645

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PolysacDB ID	1036
Carbohydrate Name	Lipoarabinomannan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium leprae (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure	127448
Proposed Function	T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic Nature	Whole killed mycobacteria leprae cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab Cs-35
Antibody Type Class	IgM
Assay System	Indirect and Competitive ELISA
Cross Reactivity	This antibody cross-reacted to M. tuberculosis and other Mycobacterium speices.
Proposed Epitope	β-D-Araf- (1-->2)-α-D-Araf-(1-->5)-α- D-Araf-(1-->5)-α-D-Araf within the branched hexa-Araf motif of mycobacterial arabinans
IEDB Epitope	76797
Proposed Utility	These antibodies could be used for screening of cell-wall mutants of mycobacteria lacking AG and AraLAM motifs and the recognition of biosynthetic intermediates of cell-wall polysaccharides unique to mycobacteria.
Curator ID	AA + AS
Date of Curation	10-01-2010
References	12368438

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PolysacDB ID	1535
Carbohydrate Name	Glycosphingolipid antigen (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leishmania amazonensis (NCBI Taxonomy) (Drugpedia)
Basic Structure	The structure of the glycosphingolipid is as follows : α-Neup5Ac-(2-->3)-β-D-Galp-(1-->3)-β-D-GalpNAc-(1-->4)-β-D-Galp [branched to α-Neup5Ac-(2-->3)-] -(1-->4)-β-D-Glcp-(1-?)-CER-(?--/Ceramide/
BCSDB Structure	130463
Proposed Function	N/A
Antigenic Nature	L. amazonensis amastigotes
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 1C3
Antibody Type Class	N/A
Assay System	Indirect immunofluorescence, immunoblotting and immunoprecipitation
Cross Reactivity	This Mab reacted with amastigotes and cross-reacts with gp63 from L. amazonensis promastigotes
Proposed Epitope	Ceramide-N-acetylneuraminic acid (GM1) and ceramide-N-tetrose-di-acetylneuraminic acid (GDla) residues seemed to be a part of the epitope
IEDB Epitope	N/A
Proposed Utility	MAb 1C3 Fab fragments inhibited about 60% of the penetration of amastigotes into macrophages
Curator ID	AA + AS
Date of Curation	27-08-2010
References	PMC280813

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PolysacDB ID	1546
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leishmania donovani chagasi (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	High molecular leishmanial antigen complexes
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 6C4
Antibody Type Class	IgG2b
Assay System	Immunofluorescence and ELISA
Cross Reactivity	N/A
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab has the promise to serve as a diagnostic tool in clinical samples
Curator ID	AA + AS
Date of Curation	03-09-2010
References	Mem. Inst. Oswaldo. Cruz. Suppl.1, Vol83, November 1987

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PolysacDB ID	1547
Carbohydrate Name	Lipophosphoglycan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leishmania mexicana (NCBI Taxonomy) (Drugpedia)
Basic Structure	LPG contains [PO4-->6Gal(β1-->4)Man(α1)] phosphosaccharide repeats linked to a conserved phosphosaccharide core and a conserved lyso alkylphosphatidylinositol residue. In contrast to L. donovani LPG, which exclusively contains the phosphodisaccharide repeats
BCSDB Structure	2568
Proposed Function	N/A
Antigenic Nature	Concanavalin A (ConA)-binding membrane components from L. mexicana
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab L7.25
Antibody Type Class	IgM
Assay System	ELISA, immunoblotting
Cross Reactivity	This Mab cross-reacted with a highly glycosylated protein - acid phosphatase
Proposed Epitope	The epitope was proposed to consist of phosphosaccharide repeats or the sugar residues forming the cap at the non-reducing end
IEDB Epitope	76720
Proposed Utility	The epitopes recognized by this Mab have been localized in promastigotes and infected macrophages
Curator ID	AA + AS
Date of Curation	03-09-2010
References	1721919

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PolysacDB ID	1548
Carbohydrate Name	Lipophosphoglycan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leishmania mexicana (NCBI Taxonomy) (Drugpedia)
Basic Structure	LPG contains [PO4-->6Gal(β1-->4)Man(α1)] phosphosaccharide repeats linked to a conserved phosphosaccharide core and a conserved lyso alkylphosphatidylinositol residue. In contrast to L. donovani LPG, which exclusively contains the phosphodisaccharide repeats
BCSDB Structure	2568
Proposed Function	N/A
Antigenic Nature	Con A binding proteins
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab AP3
Antibody Type Class	IgG1
Assay System	ELISA, immunoblotting
Cross Reactivity	This Mab cross-reacted with a highly glycosylated protein - acid phosphatase
Proposed Epitope	The epitope was proposed to consist of phosphosaccharide repeats or the sugar residues forming the cap at the non-reducing end
IEDB Epitope	76720
Proposed Utility	The epitopes recognized by this Mab have been localized in promastigotes and infected macrophages
Curator ID	AA + AS
Date of Curation	04-09-2010
References	1721919

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PolysacDB ID	1549
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leishmania mexicana (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Con A binding proteins
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab L3.13
Antibody Type Class	IgG1
Assay System	ELISA, immunoblotting
Cross Reactivity	This Mab cross-reacted with a highly glycosylated protein - acid phosphatase
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	The epitopes recognized by this Mab have been localized in promastigotes and infected macrophages
Curator ID	AA + AS
Date of Curation	04-09-2010
References	1721919

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PolysacDB ID	1550
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leishmania tropica [LRC-L36] (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	L . tropica (LRC-L36)membranes
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab XCIV 1 H2-A8(T1 l)
Antibody Type Class	IgM
Assay System	Radioimmunoprecipitation, ELISA, indirect immunofluorescence and Western blot analysis
Cross Reactivity	This Mab is completely specific for L. tropica
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab should prove useful for diagnosis and epidemiological studies
Curator ID	AA + AS
Date of Curation	05-09-2010
References	3302043

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PolysacDB ID	1551
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leishmania tropica [LRC-L36] (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	L . tropica (LRC-L36)membranes
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab IS-1 1H10-D4 (T13
Antibody Type Class	IgG1
Assay System	Radioimmunoprecipitation, ELISA, indirect immunofluorescence and Western blot analysis
Cross Reactivity	This Mab is completely specific for L. tropica
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab should prove useful for diagnosis and epidemiological studies
Curator ID	AA + AS
Date of Curation	05-09-2010
References	3302043

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PolysacDB ID	1552
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leishmania tropica [LRC-L36] (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	L . tropica (LRC-L36)membranes
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab IS-1 2B4-E3 (T14]
Antibody Type Class	IgG1
Assay System	Radioimmunoprecipitation, ELISA, indirect immunofluorescence and Western blot analysis
Cross Reactivity	This Mab is completely specific for L. tropica
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab should prove useful for diagnosis and epidemiological studies
Curator ID	AA + AS
Date of Curation	06-09-2010
References	3302043

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PolysacDB ID	1553
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leishmania tropica [LRC-L36] (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	L . tropica (LRC-L36)membranes
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab IS-2 2G7-A8( TI5]
Antibody Type Class	IgG3
Assay System	Radioimmunoprecipitation, ELISA, indirect immunofluorescence and Western blot analysis
Cross Reactivity	This Mab is completely specific for L. tropica
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab should prove useful for diagnosis and epidemiological studies
Curator ID	AA + AS
Date of Curation	06-09-2010
References	3302043

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PolysacDB ID	1560
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leptospira interrogans serovar copenhageni (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Whole cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab F12 C3
Antibody Type Class	IgG2a
Assay System	Microscopic agglutination test, double gel diffusion, Passive protection experiments, immunoblotting
Cross Reactivity	This Mab cross-reacted with serovars icterohaemorrhagiae
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab gave protection against challenge with virulent serovar copenhageni
Curator ID	AA + AS
Date of Curation	08-09-2010
References	2778433

Record - 20 of 151 [TOP]

PolysacDB ID	1562
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leptospira borgpetersenii serovar hardjo type hardjobovis (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Killed wholecell antigen
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab M551
Antibody Type Class	IgG3
Assay System	Indirect ELISA, immunoblotting
Cross Reactivity	This Mab reacted with serovar hardjo type hardjoprajitno, but not antigens from serovar sejroe, the other 10 pathogenic serovars, or serovar patoc
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab has the potential for incorporation into competitive ELISAs for the detection of antibodies to hardjo strains
Curator ID	AA + AS
Date of Curation	09-09-2010
References	PMC1189517

Record - 21 of 151 [TOP]

PolysacDB ID	1563
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leptospira borgpetersenii serovar hardjo type hardjobovis (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Killed wholecell antigen
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab M552
Antibody Type Class	IgG3
Assay System	Indirect ELISA, immunoblotting
Cross Reactivity	This Mab reacted with serovar hardjo type hardjoprajitno, but not antigens from serovar sejroe, the other 10 pathogenic serovars, or serovar patoc
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab has the potential for incorporation into competitive ELISAs for the detection of antibodies to hardjo strains
Curator ID	AA + AS
Date of Curation	09-09-2010
References	PMC1189517

Record - 22 of 151 [TOP]

PolysacDB ID	1564
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leptospira borgpetersenii serovar hardjo type hardjobovis (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Killed wholecell antigen
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab M553
Antibody Type Class	IgG1
Assay System	Indirect ELISA, immunoblotting
Cross Reactivity	This Mab reacted with serovar hardjo type hardjoprajitno, but not antigens from serovar sejroe, the other 10 pathogenic serovars, or serovar patoc
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab has the potential for incorporation into competitive ELISAs for the detection of antibodies to hardjo strains
Curator ID	AA + AS
Date of Curation	09-09-2010
References	PMC1189517

Record - 23 of 151 [TOP]

PolysacDB ID	1565
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leptospira borgpetersenii serovar hardjo type hardjobovis (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Killed wholecell antigen
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab M555
Antibody Type Class	IgG3
Assay System	Indirect ELISA, immunoblotting
Cross Reactivity	This Mab reacted with serovar hardjo type hardjoprajitno, but not antigens from serovar sejroe, the other 10 pathogenic serovars, or serovar patoc
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab has the potential for incorporation into competitive ELISAs for the detection of antibodies to hardjo strains
Curator ID	AA + AS
Date of Curation	09-09-2010
References	PMC1189517

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PolysacDB ID	1566
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leptospira borgpetersenii serovar hardjo type hardjobovis (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Killed wholecell antigen
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab M558
Antibody Type Class	IgG3
Assay System	Indirect ELISA, immunoblotting
Cross Reactivity	This Mab reacted with serovar hardjo type hardjoprajitno, but not antigens from serovar sejroe, the other 10 pathogenic serovars, or serovar patoc
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab has the potential for incorporation into competitive ELISAs for the detection of antibodies to hardjo strains
Curator ID	AA + AS
Date of Curation	10-09-2010
References	PMC1189517

Record - 25 of 151 [TOP]

PolysacDB ID	1567
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Leptospira borgpetersenii serovar hardjo type hardjobovis (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Killed wholecell antigen
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab M559
Antibody Type Class	IgG3
Assay System	Indirect ELISA, immunoblotting
Cross Reactivity	This Mab reacted with serovar hardjo type hardjoprajitno, but not antigens from serovar sejroe, the other 10 pathogenic serovars, or serovar patoc
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab has the potential for incorporation into competitive ELISAs for the detection of antibodies to hardjo strains
Curator ID	AA + AS
Date of Curation	10-09-2010
References	PMC1189517

Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036