| PolysacDB ID | 1535 |
| Carbohydrate Name | Glycosphingolipid antigen (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Leishmania amazonensis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The structure of the glycosphingolipid is as follows : α-Neup5Ac-(2-->3)-β-D-Galp-(1-->3)-β-D-GalpNAc-(1-->4)-β-D-Galp [branched to α-Neup5Ac-(2-->3)-] -(1-->4)-β-D-Glcp-(1-?)-CER-(?--/Ceramide/ |
| BCSDB Structure | 130463 |
| Proposed Function | N/A |
| Antigenic Nature | L. amazonensis amastigotes |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 1C3 |
| Antibody Type Class | N/A |
| Assay System | Indirect immunofluorescence, immunoblotting and immunoprecipitation |
| Cross Reactivity | This Mab reacted with amastigotes and cross-reacts with gp63 from L. amazonensis promastigotes |
| Proposed Epitope | Ceramide-N-acetylneuraminic acid (GM1) and ceramide-N-tetrose-di-acetylneuraminic acid (GDla) residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | MAb 1C3 Fab fragments inhibited about 60% of the penetration of amastigotes into macrophages |
| Curator ID | AA + AS |
| Date of Curation | 27-08-2010
|
| References | PMC280813 |