|
|
|
|
Home | Search | Advance Search | Browse | Online Submission | Documentation & FAQ | Team | Contact us |
|
| PolysacDB ID | 1576 |
| Carbohydrate Name | Meningococcal polysaccharide group B (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis B (CN7783) (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab MB-32 |
| Antibody Type Class | IgM |
| Assay System | Radioimmunoassay, counter immunoelectrophoresis and agglutination |
| Cross Reactivity | N/A |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab conferred very weak passive protection of mice infected with either Neisseria meningitidis group B or Escherichia coli K 1 |
| Curator ID | AA + AS |
| Date of Curation | 12-09-2010 |
| References | 6415230 |
| PolysacDB ID | 1577 |
| Carbohydrate Name | Meningococcal polysaccharide group B (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis B (CN7783) (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab MB-34 |
| Antibody Type Class | IgM |
| Assay System | Radioimmunoassay, counter immunoelectrophoresis and agglutination |
| Cross Reactivity | N/A |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab conferred passive protection of mice infected with either Neisseria meningitidis group B or Escherichia coli K 1 |
| Curator ID | AA + AS |
| Date of Curation | 12-09-2010 |
| References | 6415230 |
|
Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036 |