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| PolysacDB ID | 1578 |
| Carbohydrate Name | N-propionylated group B meningococcal polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | Nil |
| Antibodies | Polysera |
| Antibody Type Class | N/A |
| Assay System | Radioactive binding inhibition assay, ELISA, Bactericidal assay |
| Cross Reactivity | This antisera cross-reacted with capsular polysaccharide of E. coli K1 |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This antisera was bactericidal for Group B meningococci |
| Curator ID | AA + AS |
| Date of Curation | 12-09-2010 |
| References | 2469720 |
| PolysacDB ID | 1789 |
| Carbohydrate Name | N-propionylated group B meningococcal polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->8)-linked sialic acid residues |
| BCSDB Structure | N/A |
| Proposed Function | It is an important virulence factor |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | N-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37°C for 5 days |
| Antibodies | Mab 13A8 |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, bactericidal assays |
| Cross Reactivity | N/A |
| Proposed Epitope | The epitope was located only on extended helical segments of the polysaccharide |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the elucidation of the capsular polysaccharide structure |
| Curator ID | AA + AS |
| Date of Curation | 01-11-2010 |
| References | PMC2196336 |
| PolysacDB ID | 1790 |
| Carbohydrate Name | N-propionylated group B meningococcal polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->8)-linked sialic acid residues |
| BCSDB Structure | N/A |
| Proposed Function | It is an important virulence factor |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | N-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37°C for 5 days |
| Antibodies | Mab 6E10 |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, bactericidal assays |
| Cross Reactivity | N/A |
| Proposed Epitope | The epitope was located only on extended helical segments of the polysaccharide |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the elucidation of the capsular polysaccharide structure |
| Curator ID | AA + AS |
| Date of Curation | 01-11-2010 |
| References | PMC2196336 |
| PolysacDB ID | 1791 |
| Carbohydrate Name | N-propionylated group B meningococcal polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->8)-linked sialic acid residues |
| BCSDB Structure | N/A |
| Proposed Function | It is an important virulence factor |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | N-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37°C for 5 days |
| Antibodies | Mab 13A11 |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, bactericidal assays |
| Cross Reactivity | N/A |
| Proposed Epitope | The epitope was located only on extended helical segments of the polysaccharide |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the elucidation of the capsular polysaccharide structure |
| Curator ID | AA + AS |
| Date of Curation | 02-11-2010 |
| References | PMC2196336 |
| PolysacDB ID | 1792 |
| Carbohydrate Name | N-propionylated group B meningococcal polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->8)-linked sialic acid residues |
| BCSDB Structure | N/A |
| Proposed Function | It is an important virulence factor |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | N-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37°C for 5 days |
| Antibodies | Mab 13D9 |
| Antibody Type Class | IgG2a |
| Assay System | ELISA, bactericidal assays |
| Cross Reactivity | N/A |
| Proposed Epitope | The epitope was located only on extended helical segments of the polysaccharide |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab had bactericidal activity |
| Curator ID | AA + AS |
| Date of Curation | 02-11-2010 |
| References | PMC2196336 |
| PolysacDB ID | 1793 |
| Carbohydrate Name | N-propionylated group B meningococcal polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->8)-linked sialic acid residues |
| BCSDB Structure | N/A |
| Proposed Function | It is an important virulence factor |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | N-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37°C for 5 days |
| Antibodies | Mab 6B9 |
| Antibody Type Class | IgG2a |
| Assay System | ELISA, bactericidal assays |
| Cross Reactivity | N/A |
| Proposed Epitope | The epitope was located only on extended helical segments of the polysaccharide and also comprised short internal fragments |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the elucidation of the capsular polysaccharide structure |
| Curator ID | AA + AS |
| Date of Curation | 02-11-2010 |
| References | PMC2196336 |
| PolysacDB ID | 1794 |
| Carbohydrate Name | N-propionylated group B meningococcal polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->8)-linked sialic acid residues |
| BCSDB Structure | N/A |
| Proposed Function | It is an important virulence factor |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | N-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37°C for 5 days |
| Antibodies | Mab 12C5 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, bactericidal assays |
| Cross Reactivity | N/A |
| Proposed Epitope | The epitope was located only on extended helical segments of the polysaccharide |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab had bactericidal activity |
| Curator ID | AA + AS |
| Date of Curation | 02-11-2010 |
| References | PMC2196336 |
| PolysacDB ID | 1795 |
| Carbohydrate Name | N-propionylated group B meningococcal polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->8)-linked sialic acid residues |
| BCSDB Structure | N/A |
| Proposed Function | It is an important virulence factor |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | N-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37°C for 5 days |
| Antibodies | Mab 12E12 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA, bactericidal assays |
| Cross Reactivity | N/A |
| Proposed Epitope | The epitope was located only on extended helical segments of the polysaccharide |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab had bactericidal activity |
| Curator ID | AA + AS |
| Date of Curation | 02-11-2010 |
| References | PMC2196336 |
| PolysacDB ID | 1796 |
| Carbohydrate Name | N-propionylated group B meningococcal polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->8)-linked sialic acid residues |
| BCSDB Structure | N/A |
| Proposed Function | It is an important virulence factor |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | N-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37°C for 5 days |
| Antibodies | Mab 14F10 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA, bactericidal assays |
| Cross Reactivity | N/A |
| Proposed Epitope | The epitope was located only on extended helical segments of the polysaccharide |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab had bactericidal activity |
| Curator ID | AA + AS |
| Date of Curation | 03-11-2010 |
| References | PMC2196336 |
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Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036 |