PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
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PolysacDB ID1633
Carbohydrate NamePhenolic glycolipid antigen   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose
BCSDB Structure114263
Proposed FunctionIt has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells
Antigenic NaturePartially purified phenolic glycolipid from M. leprae
Carrier NameNil
Conjugate MethodNil
AntibodiesMab A1E
Antibody Type ClassIgM
Assay SystemELISA, TLC autoradiography and immunofluorescence
Cross ReactivityThis Mab was specific to M. leprae glycolipid but cross-reacted with Mycobacterium terrae. Mycobacterium nonchromogenicum and Mycobacterium fortuitium
Proposed EpitopeTerminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope
IEDB Epitope76895
Proposed UtilityThis Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence
Curator IDAA + AS
Date of Curation26-09-2010
ReferencesPMC263407

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PolysacDB ID1634
Carbohydrate NamePhenolic glycolipid antigen   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose
BCSDB Structure114263
Proposed FunctionIt has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells
Antigenic NaturePartially purified phenolic glycolipid from M. leprae
Carrier NameNil
Conjugate MethodNil
AntibodiesMab
Antibody Type ClassIgM
Assay SystemELISA, TLC autoradiography and immunofluorescence
Cross ReactivityThis Mab was specific to M. leprae glycolipid
Proposed EpitopeTerminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope
IEDB Epitope76895
Proposed UtilityThis Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence
Curator IDAA + AS
Date of Curation26-09-2010
ReferencesPMC263407

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PolysacDB ID1635
Carbohydrate NamePhenolic glycolipid antigen   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose
BCSDB Structure114263
Proposed FunctionIt has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells
Antigenic NaturePartially purified phenolic glycolipid from M. leprae
Carrier NameNil
Conjugate MethodNil
AntibodiesMab A2A
Antibody Type ClassIgM
Assay SystemELISA, TLC autoradiography and immunofluorescence
Cross ReactivityThis Mab was specific to M. leprae glycolipid
Proposed EpitopeTerminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope
IEDB Epitope76895
Proposed UtilityThis Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence
Curator IDAA + AS
Date of Curation26-09-2010
ReferencesPMC263407

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PolysacDB ID1636
Carbohydrate NamePhenolic glycolipid antigen   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose
BCSDB Structure114263
Proposed FunctionIt has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells
Antigenic NaturePartially purified phenolic glycolipid from M. leprae
Carrier NameNil
Conjugate MethodNil
AntibodiesMab A3H
Antibody Type ClassIgM
Assay SystemELISA, TLC autoradiography and immunofluorescence
Cross ReactivityThis Mab was specific to M. leprae glycolipid
Proposed EpitopeTerminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope
IEDB Epitope76895
Proposed UtilityThis Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence
Curator IDAA + AS
Date of Curation26-09-2010
ReferencesPMC263407

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PolysacDB ID1637
Carbohydrate NamePhenolic glycolipid antigen   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose
BCSDB Structure114263
Proposed FunctionIt has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells
Antigenic NaturePartially purified phenolic glycolipid from M. leprae
Carrier NameNil
Conjugate MethodNil
AntibodiesMab B2G
Antibody Type ClassIgM
Assay SystemELISA, TLC autoradiography and immunofluorescence
Cross ReactivityThis Mab was specific to M. leprae glycolipid
Proposed EpitopeTerminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope
IEDB Epitope76895
Proposed UtilityThis Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence
Curator IDAA + AS
Date of Curation26-09-2010
ReferencesPMC263407

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PolysacDB ID1638
Carbohydrate NamePhenolic glycolipid antigen   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose
BCSDB Structure114263
Proposed FunctionIt has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells
Antigenic NaturePartially purified phenolic glycolipid from M. leprae
Carrier NameNil
Conjugate MethodNil
AntibodiesMab B5B
Antibody Type ClassIgM
Assay SystemELISA, TLC autoradiography and immunofluorescence
Cross ReactivityThis Mab was specific to M. leprae glycolipid
Proposed EpitopeTerminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope
IEDB Epitope76895
Proposed UtilityThis Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence
Curator IDAA + AS
Date of Curation26-09-2010
ReferencesPMC263407

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PolysacDB ID1639
Carbohydrate NamePhenolic glycolipid antigen   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose
BCSDB Structure114263
Proposed FunctionIt has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells
Antigenic NaturePartially purified phenolic glycolipid from M. leprae
Carrier NameNil
Conjugate MethodNil
AntibodiesMab B5H
Antibody Type ClassIgM
Assay SystemELISA, TLC autoradiography and immunofluorescence
Cross ReactivityThis Mab was specific to M. leprae glycolipid
Proposed EpitopeTerminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope
IEDB Epitope76895
Proposed UtilityThis Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence
Curator IDAA + AS
Date of Curation26-09-2010
ReferencesPMC263407

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PolysacDB ID1640
Carbohydrate NamePhenolic glycolipid antigen   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose
BCSDB Structure114263
Proposed FunctionIt has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells
Antigenic NaturePartially purified phenolic glycolipid from M. leprae
Carrier NameNil
Conjugate MethodNil
AntibodiesMab B8F
Antibody Type ClassIgM
Assay SystemELISA, TLC autoradiography and immunofluorescence
Cross ReactivityThis Mab was specific to M. leprae glycolipid
Proposed EpitopeTerminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope
IEDB Epitope76895
Proposed UtilityThis Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence
Curator IDAA + AS
Date of Curation26-09-2010
ReferencesPMC263407

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PolysacDB ID1641
Carbohydrate NamePhenolic glycolipid antigen   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose
BCSDB Structure114263
Proposed FunctionIt has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells
Antigenic NaturePartially purified phenolic glycolipid from M. leprae
Carrier NameNil
Conjugate MethodNil
AntibodiesMab B9D
Antibody Type ClassIgM
Assay SystemELISA, TLC autoradiography and immunofluorescence
Cross ReactivityThis Mab cross-reacted with M. kansasii phenolic glycolipid and cross-reacted with whole cells of 20 mycobacterial strains
Proposed EpitopeTerminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope
IEDB Epitope76895
Proposed UtilityThis Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence
Curator IDAA + AS
Date of Curation26-09-2010
ReferencesPMC263407

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PolysacDB ID1642
Carbohydrate NamePhenolic glycolipid antigen   (Drugpedia)
Carbohydrate ClassGlycolipid
Microbe NameMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose
BCSDB Structure114263
Proposed FunctionIt has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells
Antigenic NaturePartially purified phenolic glycolipid from M. leprae
Carrier NameNil
Conjugate MethodNil
AntibodiesMab B1OH
Antibody Type ClassIgM
Assay SystemELISA, TLC autoradiography and immunofluorescence
Cross ReactivityThis Mab was specific to M. leprae glycolipid
Proposed EpitopeTerminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope
IEDB Epitope76895
Proposed UtilityThis Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence
Curator IDAA + AS
Date of Curation27-09-2010
ReferencesPMC263407

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