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| PolysacDB ID | 1728 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Phenolic glycolipid-1 and heat-killed M. leprae |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab III603.8 |
| Antibody Type Class | IgM |
| Assay System | ELISA |
| Cross Reactivity | This Mab reacted with deacylated Phenolic glycolipid-1[ PGL-I (PGL-I OH )], but did not bind to PGL antigens from M. kansasii (mycoside A), M. bovis (deacylated mycosideB), and M. tuberculosis (PGL-Tb OH ) |
| Proposed Epitope | The outer monosaccharide, disaccharide and the trisaccharide all contributed to the epitope recognized by this Mab |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab was used for the development of peptide mimotopes resembling the carbohydrate structures recognized by this Mab |
| Curator ID | AA + AS |
| Date of Curation | 16-10-2010 |
| References | 15094167 |
| PolysacDB ID | 1729 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Phenolic glycolipid-1 and heat-killed M. leprae |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab VI703 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA |
| Cross Reactivity | This Mab reacted with deacylated Phenolic glycolipid-1[ PGL-I (PGL-I OH )], but did not bind to PGL antigens from M. kansasii (mycoside A), M. bovis (deacylated mycosideB), and M. tuberculosis (PGL-Tb OH ) |
| Proposed Epitope | The outer monosaccharide, disaccharide and the trisaccharide all contributed to the epitope recognized by this Mab |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab was used for the development of peptide mimotopes resembling the carbohydrate structures recognized by this Mab |
| Curator ID | AA + AS |
| Date of Curation | 17-10-2010 |
| References | 15094167 |
| PolysacDB ID | 1730 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 1-21 |
| Antibody Type Class | N/A |
| Assay System | Inhibitory ELISA |
| Cross Reactivity | This Mab recognized the outer (nonreducing end) monosaccharide of the trisaccharide chain of PGL-I |
| Proposed Epitope | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 17-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1731 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 1-24 |
| Antibody Type Class | N/A |
| Assay System | Inhibitory ELISA |
| Cross Reactivity | This Mab recognized the outer (nonreducing end) monosaccharide of the trisaccharide chain of PGL-I |
| Proposed Epitope | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 17-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1732 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 1-25 |
| Antibody Type Class | N/A |
| Assay System | Inhibitory ELISA |
| Cross Reactivity | This Mab recognized the outer (nonreducing end) monosaccharide of the trisaccharide chain of PGL-I |
| Proposed Epitope | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 17-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1733 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab ml 6A12 |
| Antibody Type Class | N/A |
| Assay System | Inhibitory ELISA |
| Cross Reactivity | This Mab recognized the outer disaccharide of the trisaccharide chain of PGL-I |
| Proposed Epitope | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 18-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1734 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab ml 8A2 |
| Antibody Type Class | N/A |
| Assay System | Inhibitory ELISA |
| Cross Reactivity | This Mab recognized the outer disaccharide of the trisaccharide chain of PGL-I |
| Proposed Epitope | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 18-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1735 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab ml 8B2 |
| Antibody Type Class | N/A |
| Assay System | Inhibitory ELISA |
| Cross Reactivity | This Mab recognized the outer disaccharide of the trisaccharide chain of PGL-I |
| Proposed Epitope | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 18-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1736 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab PG2 B8F |
| Antibody Type Class | N/A |
| Assay System | Inhibitory ELISA |
| Cross Reactivity | This Mab recognized the outer disaccharide of the trisaccharide chain of PGL-I |
| Proposed Epitope | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 18-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1737 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab F47-21-3 |
| Antibody Type Class | N/A |
| Assay System | Inhibitory ELISA |
| Cross Reactivity | This Mab recognized the outer disaccharide of the trisaccharide chain of PGL-I and also some parts of an unknown sugar |
| Proposed Epitope | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 19-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1738 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab SF 1 |
| Antibody Type Class | N/A |
| Assay System | Inhibitory ELISA |
| Cross Reactivity | This Mab recognized the outer trisaccharide chain of PGL-I |
| Proposed Epitope | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 19-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1739 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 3D1-A9 |
| Antibody Type Class | N/A |
| Assay System | Inhibitory ELISA |
| Cross Reactivity | This Mab recognized the phenol group and the structure around the branching point on the carrier protein in addition to the trisaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 19-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1740 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab DZ 1 |
| Antibody Type Class | N/A |
| Assay System | Inhibitory ELISA |
| Cross Reactivity | This Mab recognized the inner (reducing end) disaccharide chain of the trisaccharide part of PGL-1 |
| Proposed Epitope | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 20-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1741 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 2G3-A8 |
| Antibody Type Class | N/A |
| Assay System | Inhibitory ELISA |
| Cross Reactivity | MAb 2G3-A8 recognized the inner monosaccharide, phenol group and the structure around the branching point on the carrier protein |
| Proposed Epitope | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 20-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1742 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe Name | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed Function | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature | Whole cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Polysera |
| Antibody Type Class | IgM |
| Assay System | ELISA |
| Cross Reactivity | The antisera cross-reacted withserovars 5, 12, 18, 20, 23, 24, and 28 of M. avium-M. intracellulare-M. scrofulaceum serocomplex |
| Proposed Epitope | The trisaccharide appendages of the phenolic glycolipids seemed to be a part of the epitope |
| IEDB Epitope | 76905 |
| Proposed Utility | A specific assay for IgM activity to the specific M. leprae glycolipid, particularly in the preclinical state of the lepromatous form of the disease, may enable earlier chemotherapy and thereby prevent deformity and eliminate the infectious reservoir |
| Curator ID | AA + AS |
| Date of Curation | 20-10-2010 |
| References | PMC264610 |
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Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036 |