PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
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PolysacDB ID2419
Carbohydrate NameStreptococcal A carbohydrate   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
Microbe NameStreptococcus Group A   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed FunctionThis Carbohydrate is highly immunodominant
Antigenic NatureSera of humans having IgM myeloma
Carrier NameNil
Conjugate MethodNil
AntibodiesMab AC8
Antibody Type ClassIgM
Assay SystemSolid-phase enzyme-linked immunoassay, Streptococcal agglutination assay
Cross ReactivityAC8 agglutinated preferentially group A streptococci
Proposed EpitopeAC8 appears to be specific for N-acetly-D-glucosamine (GlcNAc) side chains β(1-->2)-linked to rhamnose
IEDB Epitope76687
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation07-05-2011
References2579417

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PolysacDB ID2420
Carbohydrate NameStreptococcal A carbohydrate   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
Microbe NameStreptococcus Group A   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed FunctionThis Carbohydrate is highly immunodominant
Antigenic NatureSera of humans having IgM myeloma
Carrier NameNil
Conjugate MethodNil
AntibodiesMab AC179
Antibody Type ClassIgM
Assay SystemSolid-phase enzyme-linked immunoassay, Streptococcal agglutination assay
Cross ReactivityACI79 was most active in agglutinating A variant (Av) and group C streptococci
Proposed EpitopeAC179 is directed to α-linked rhamnose oligosaccharides
IEDB Epitope76687
Proposed UtilityAC179 induced complement activation in the presence of the carbohydrate
Curator IDAA + AS
Date of Curation07-05-2011
References2579417

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PolysacDB ID2426
Carbohydrate NameStreptococcal A carbohydrate   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
Microbe NameStreptococcus Group A   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed FunctionThis Carbohydrate is highly immunodominant
Antigenic NatureWhole cells
Carrier NameNil
Conjugate MethodNil
AntibodiesAntisera
Antibody Type ClassN/A
Assay SystemRadioimmunoassay
Cross ReactivityN/A
Proposed EpitopeThe antigenic determinant was known as α hapten that had a estimated molecular weight of 1100 daltons and a rhamnose: glucosamine molar ratio of 6:1
IEDB Epitope76687
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation10-05-2011
References4795261

Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036