SAPdb: Entry Card with Detailed Information of Peptide

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Details of SAPdb ID 1122
Primary information
SAPdb_ID1122
PMID21472901
Year2011
Name1 or Boc-{(N-Cbz)-Lys}-Phe-Ala
SequenceKFA
N-Terminal ModificationN-Cbz lysine (Cbz = benzyloxy-carbonyl) and Boc (N-t-Butoxycarbonyl)
C-Terminal ModificationFree
Non-terminal ModicationNone
Length3
Peptide/Conjugate/MixturePeptide derivative
Conjugate PartnerCoupling with 5,5’-dibromomethyl-2,2’-bipyridin
TechniqueTEM (Transmission Electron Microscopy), SEM (Scanning Electron Microscopy) NMR and Mass spectrometery
SolventTHF (Tetrahydrofuran):Water (1:1)
MethodConjugate 1 was dissolved in THF at a concentration of 4.0mg/mL. Addition of the same amount of water into the prior solution in THF resulted in a transparent solution and the formation of vesicles. Upon ultrasound treatment for about 10 mins, the vesicles transferred into networks of nanofibers. The nanofibers rearranged into vesicles upon incubation in the 60 C water bath.
Concentration2mg/ml
pHNA
Temperature
60°C
Incubation Period20-30minutes
Self-Assembly FormationYes
Type of Self-Assemblyvesicle structure
Size of Self-Assembled structureNA
Linear/CyclicLinear
Stability of NanostructureStable
CommentNA
Secondary information
Physico-Chemical properties
Physico-Chemical properties
STRUCTURE
Predicted Structure
SMILESN.A.