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The total number entries retrieved from this search areID | Sequence | Name | Nature of peptide or cargo | Assay | Tissue permeability | Tissue Sample | PUBMED ID |
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1393 | T | Capsaicin | Repeated capsaicin applications are assumed to cause desensitization of the nasal mucosa and a decreased secretory response | Immunocytochemistry, electron microscopy | The number of goblet cells was increased in the nasal region. CGRP-Iike activity was decreased in biopsies taken from the test sides of the paranasal sinuses when compared to control. | Nasal mucosa of New Zealand White rabbits | 8737771 |
1396 | T | Capsaicin | Nociceptive responses to various noxious stimuli are inhibited or abolished in capsaicin-treated animals. This effect is presumed to arise from the toxic action of capsaicin and the consequent neurodegeneration of C-fibre nociceptors. | Pain response evaluated by a visual analogue scale | Capsaicin (50 nmol, 50 µl) produced a remarkable pain response (considered as 100 in the VAS), sneezing and secretion of copious flow of nasal fluid. Capsaicin applications were performed every day for 5-7 days until the painful response reported by each subject was reduced by about 80% | Nostrils of human subjects | 8443036 |
1398 | T | Capsaicin | Affects not only sensory nerves but impacts on THI sympathetic nerves in the nasal mucosa | Immunocytochemistry | In the nasal mucosa of toluene diisocyanate sensitized guinea pigs, substance P (SP)- and tyrosine hydroxylase (TH)-like immunoreactive (SPI and THI) fibers seemed to decrease after capsaicin application | Nasal mucosa of guinea pigs | 7680838 |
1399 | T | Capsaicin | Capsaicin, the pungent ingredient of red peppers, when applied into the nasal mucosa induces violent sneezing, vasodilation and increases vascular permeability. | Visual analogue scale method was used to measure burning and painful sensation on application of capsaicin. | The application of capsaicin into the human nasal mucosa was immediately followed by a painful sensation that was described by all the subjects as burning. A variable number of sneezes (from I up to 8) also occurred. | Human nasal mucosa | 3370386 |
1400 | T | Capsaicin | Capsaicin activates sensory nerve endings in the nose and the paranasal sinuses, thereby stimulating protective reflexes involved in sneezing and in increased vasopermeability and stimulate mucociliary activity | The amount of nasal mucosa secreted in response to capsaicin was weighed. | Capsaicin stimulated the secretion of nasal fluid in a dose-dependent manner when administered as a single dose. | Nasal mucosa of rats | 2480171 |
1608 | T | Capsaicin | Capsaicin increases calcitonin gene-related peptide (CGRP) release from sensory neurons by stimulating vanilloid receptor-1 | Immunoassay. | Dermal IGF level increased to approximately 2000 ng/g tissue | Mice skin | 17307377 |