PRIMARY INFORMATION |
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ID | 1010 |
PMID | 24134794 |
Year | 2014 |
Sequence | GKRR |
Name | R4 (arginine-terminated peptide dendrimers) |
Length | 4 |
N-Terminal Modification | Free |
C-Terminal Modification | Free |
Linear/ Cyclic | Linear (Branched) |
Chirality | L |
Chemical Modification | None |
Origin of Peptide | Arginine-terminated peptide dendrimers of varying positive charge |
Nature of Peptide/Cargo | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups |
Mechanism | Increased transepidermal water loss and decreased skin resistance due to the interaction of dendrimers with skin lipids |
Cargo Sequence/Structure | Not mentioned |
Name of cargo
| 5-fluorouracil |
Assay | Franz diffusion cell |
Enhancer | None |
Properties of enhancer | Not applicable |
Concentration | 0.5 mL of 5 mg/mL dendrimer in HEPES solution (pH 7.4) for a predetermined time (2 h) after hydration.A minute quantity of 5-FU was added to make it as a suspension to maintain high thermodynamic activity |
Incubation time | 48 hours |
Tissue permeability (value with units) | Flux (mg/cm2/h) 25.16 ± 2.31 , Q48 (mg) 1167.05 ± 50.10 Drug content in skin (mg/cm2) 146 ± 6.44 |
Tissue Sample | Human epidermal skin |
Ex vivo/In vivo/In vitro | in vitro |
SECONDARY INFORMATION |
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STRUCTURE | |
SMILES | N.A. |