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Details of TopicalPdb ID 1094

PRIMARY INFORMATION
ID1094
PMID22072881
Year2011
SequenceRKKRRQRRR
NameTat
Length9
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideHIV-1
Nature of Peptide/CargoFor promoting the skin penetration of molecules
MechanismNot mentioned
Cargo Sequence/StructureLipophilic nature
Name of cargo
Hirsutenone (HST)
AssayIn vivo therapeutic efficacy assay
EnhancerElastic liposomes (EL)
Properties of enhancerPhospholipid vesicular system enhancing transdermal deliveries
ConcentrationNot mentioned
Incubation time4 weeks
Tissue permeability (value with units)Show significantly improvement in wound and dry skin
Tissue SamplePostaxial back skin of the mice
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H]
(CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N
[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)
C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC
(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])
N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O