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Details of TopicalPdb ID 1095

PRIMARY INFORMATION
ID1095
PMID22072881
Year2011
SequenceRKKRRQRRR
NameTat
Length9
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideHIV-1
Nature of Peptide/CargoFor promoting the skin penetration of molecules
MechanismNot mentioned
Cargo Sequence/StructureLipophilic nature
Name of cargo
Hirsutenone (HST)
AssayIn vivo therapeutic efficacy assay
EnhancerConventional cream
Properties of enhancerNot applicable
ConcentrationNot mentioned
Incubation time4 weeks
Tissue permeability (value with units)Show significantly improvement in wound and dry skin but lesser than EL/T
Tissue SamplePostaxial back skin of the mice
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H]
(CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N
[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)
C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC
(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])
N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O