Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1102

PRIMARY INFORMATION
ID1102
PMID22009459
Year2012
SequenceACSSSPSKHCG
NameTD-1
Length11
N-Terminal ModificationFITC linked through aminocaproic (Acp) spacer
C-Terminal ModificationFree
Linear/ CyclicCyclic (C2-C10)
ChiralityL
Chemical ModificationNone
Origin of PeptideSynthetic
Nature of Peptide/CargoTransdermal Delivery enhancer
MechanismCell junction structures were disrupted in the footpad skin
Cargo Sequence/StructureCCACUAAUGUCCAGCGCUUTT
Name of cargo
Modified-siRNA
AssayRT-PCR
EnhancerNone
Properties of enhancerNot applicable
Concentration50 µg/ml TD1 and 50 µg/ml siRNA
Incubation time72 hour
Tissue permeability (value with units)The level of GADPH decreased 49 %
Tissue SampleRat footpad skin
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](C)C(=O)N[C@H]1CSSC[C@H]
(NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC
(=O)[C@H]2N(C(=O)[C@@H](NC(=O)[C@@H](NC
(=O)[C@@H](NC1=O)CO)CO)CO)CCC2)CO)
CCCC[NH3])Cc1nc[nH]c1)C(=O)NCC=O