Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1105

PRIMARY INFORMATION
ID1105
PMID21119619
Year2010
SequenceACSSSPSKHCGGRRR
RRRRR
NameTD1-R8
Length20
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideSynthetic (by conjugating TD1 (ACSSSPSKHCG) and (oligoarginine) R8 )
Nature of Peptide/CargoMITF-siRNA inhibition of melanin synthesis and melanoma cell apoptosis.
MechanismMITF-siRNA-silenced MITF gene expression effectively induced a significant reduction in tyrosinase (TYR), tyrosinase-related protein 1, and melanocortin 1 receptor (MC1R) levels.
Cargo Sequence/StructureMITF-siR: sense 5′-GCAGUACCUUUCUACCACUTT-3′
Name of cargo
Microphthalmia-associated transcription factor–siRNA (MITF-siR)
AssayLaser scanning confocal microscopy
EnhancerHair clipped mice skin
Properties of enhancerNot applicable
Concentration100 µg of cream containing 0.005% MITF-siR and arginine-rich peptide (TD1-R8).
Incubation time2 hours
Tissue permeability (value with units)Significant penetration of carboxyfluorescein-labeled MITF-siR can be seen in confocal images of whole epidermis and partial dermis
Tissue SampleHair shaved back of BALB/c mice
Ex vivo/In vivo/In vitroex vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H]
(CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)
N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]
(CCCC[NH3])C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N
[C@@H](CS)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(=[NH2])
N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H]
(CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])
N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H]
(CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC
(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O