PRIMARY INFORMATION |
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ID | 1133 |
PMID | 18426410 |
Year | 2008 |
Sequence | LIGR |
Name | LIGR |
Length | 4 |
N-Terminal Modification | Free |
C-Terminal Modification | Amidation |
Linear/ Cyclic | Linear |
Chirality | L |
Chemical Modification | None |
Origin of Peptide | Derivative of SLIGRL, a known PAR-2 activating peptide |
Nature of Peptide/Cargo | Activation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivo |
Mechanism | LIGR sequence mimic the tethered ligand Sequence of PAR-2 receptor |
Cargo Sequence/Structure | Not mentioned |
Name of cargo
| Not applicable |
Assay | Fontana-Mason (F&M) stain |
Enhancer | None |
Properties of enhancer | Not applicable |
Concentration | 250 µM |
Incubation time | Twice daily, 5 days ⁄ week, for 8 weeks |
Tissue permeability (value with units) | The increase in pigment deposition induced by peptide can be seen in the Fontana-Mason (F&M) stained microscopic images of swine skin sections |
Tissue Sample | Dorsum skin of pigmented yucatan microswine |
Ex vivo/In vivo/In vitro | in vitro |
SECONDARY INFORMATION |
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STRUCTURE | |
SMILES | N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C (=O)NCC(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N |