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Details of TopicalPdb ID 1166

PRIMARY INFORMATION
ID1166
PMID15906170
Year2005
SequenceYKALRISRKLAK
NameYKAc
Length12
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideSynthetic nontransducing peptide
Nature of Peptide/CargoIt is a nontransducing peptide
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayFluorimetry analysis using Gemini SpectraMax plate reader
EnhancerNone
Properties of enhancerNone
ConcentrationFITC-labeled peptide is dissolved in propylene glycol containing 5% (w/w) oleic acid to make peptide concentration 100µM
Incubation time4 Hours
Tissue permeability (value with units)Transdermal delivery(nmol)- -̴0
Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](C)C
(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C
(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC
C[NH3])C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCC[NH3])CO