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Details of TopicalPdb ID 1177

PRIMARY INFORMATION
ID1177
PMID15906170
Year2005
SequenceYARAAARQARA
NameYARA
Length11
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideMolecularly modified TAT
Nature of Peptide/CargoMolecular modification of TAT has led to the discovery of a new, optimized PTD, YARA which can penetrate intact strips of porcine coronary artery and human saphenous vein smooth muscle.
MechanismNot mentioned
Cargo Sequence/StructurePhosphopeptide analogue of the heat shock protein (HSP) 20
Name of cargo
P20
AssayFluorimetry analysis using Gemini SpectraMax plate reader
EnhancerNone
Properties of enhancerNone
ConcentrationFITC-labeled peptide is dissolved in phosphate-buffered saline (PBS; 10 mM, pH 7.2) to make peptide concentration 100µM
Incubation time8 Hours
Tissue permeability (value with units)Rate of skin penetration(nmol/cm2/h)- -̴0.03
Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C
(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N
[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C)C=O