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Details of TopicalPdb ID 1209

PRIMARY INFORMATION
ID1209
PMID14757511
Year2004
SequencepGlu-HWSYGLRPG
NameLHRH
Length10
N-Terminal ModificationFree
C-Terminal ModificationAmidation
Linear/ CyclicCyclic
ChiralityL
Chemical ModificationpGlu= Pyroglutamic acid
Origin of PeptideSynthetic
Nature of Peptide/CargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.
MechanismMajor mechanism of iontophoretic transdermal delivery of large peptides is the convective solvent flow.
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayHPLC
EnhancerTransdermal iontophoresis
Properties of enhancerTransdermal iontophoresis utilizes low current/voltage electrostatic repulsion and electroosmotic solvent flow
Concentration0.5 mM of peptide in a buffer which consisted of 25 mM Hepes and 150 mM NaCl (pH 7.4)
Incubation timeIontophoretic experiments lasted for 24 h
Tissue permeability (value with units)LHRH flux= 12.39 ± 5.32 µg h−1 cm−2 at 75% pulsed DC (500 Hz)
Tissue SampleEpidermis of human cadaver skin
Ex vivo/In vivo/In vitroex vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.