Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1226

PRIMARY INFORMATION
ID1226
PMID11337153
Year2001
SequenceCSNLSTCVLGKLSQEL
HKLQTYPRTNTGSGTP
NameSalmon calcitonin (sCT)
Length32
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideSynthetic
Nature of Peptide/CargoA peptide hormone which inhibits bone resorption by inhibiting the activity of osteoclasts.
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayRadioimmunoassay
EnhancerPulse depolarization-iontophoresis (PDP-IP) system
Properties of enhancerIt depolarizes the skin surface after application of each pulse.
Concentration3.5µg/Kg
Incubation time45 min
Tissue permeability (value with units)Area Under the Curve0–120 min (ng·min/ml)=19.8±2.9 , Absolute Bioavailability (%)=33.2 , Relative Bioavailability (%)=68.6
Tissue SampleStratum corneum of the stomach of SD male rats
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H]
(C=O)CCC)[C@H](O)C)CO)[C@H](O)C)CC(=O)N)[C@H](O)C)CCCNC(=N)N)CCC)Cc1ccc(cc1)O)[C@H](O)C)
CCC(=O)N)CC(C)C)CCCCN)Cc1[nH]cnc1)CC(C)C)CCC(=O)O)CCC(=O)N)CO)CC(C)
C)CCCCN)CC(C)C)C(C)C)CS)[C@H](O)C)CO)CC(C)C)CC(=O)N)CO)CS