| PRIMARY INFORMATION |
|---|
| ID | 1266 |
| PMID | 8268857 |
| Year | 1993 |
| Sequence | SNLST-Asu-VLGKLSQELH
KLQTYPRTDVGAGTP |
| Name | Elcatonin |
| Length | 31 |
| N-Terminal Modification | Free |
| C-Terminal Modification | Amidation |
| Linear/ Cyclic | Cyclic (bond between Ser1 and Asu6) |
| Chirality | L |
| Chemical Modification | Asu=Aminosuberic Acid |
| Origin of Peptide | Synthetic [Asu1,7]-eel calcitonin |
| Nature of Peptide/Cargo | It stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorption |
| Mechanism | Not mentioned |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Calcium C-Test Wako kit, Ames method, Alkaline Phospha K-Test and ANOVA |
| Enhancer | Vitamin D[1,25(OH)2D3] is used in combination to enhance results |
| Properties of enhancer | Not mentioned |
| Concentration | 0.5g of gel ointment/4cm2 of skin area. Gel ointment:2g Carbopol 934, 25mg Elcatonin, 5µg of 1,25(OH)2D3, 1ml Gentamicin solution, 1.5g OTG, 1g Taurocholate and 100g purified water |
| Incubation time | 6 times for 48 hours |
| Tissue permeability (value with units) | Parameters studied: Ca(mg/dl)- 8.80±0.27/8.94±0.17(control), P(mg/dl)- 5.22±0.36/5.58±0.55(control) and Alkaline phosphatase- 22.21±4.01/18.83±0.75(control) |
| Tissue Sample | Abdominal skin of female wistar rats |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
