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Details of TopicalPdb ID 1276

PRIMARY INFORMATION
ID1276
PMID8156912
Year1994
SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIP
Length28
N-Terminal ModificationStearic acid fused on N-terminus by amide bond
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideDerivative of VIP
Nature of Peptide/CargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.
MechanismVIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder.
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayRadioactive assay, Measurement of latency of first cup
EnhancerNone
Properties of enhancerNot applicable
ConcentrationEach rat received 30-50 µg Stearyl-VIP in about 10 µl ointment (2 g lubricant [K-Y Vaginal Lubricating Jelly], 10 mg Stearyl-VIP, 1.7 ml nitroglycerin [1 mg/ml] and 130 µl of DMSO).
Incubation time45 minutes
Tissue permeability (value with units)Measurement of latency of first cup: Control:25.5 minutes , Test:19 minutes
Tissue SampleIn castrated testosterone treated rats
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.