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Details of TopicalPdb ID 1294

PRIMARY INFORMATION
ID1294
PMID8080985
Year1994
SequenceGrGDIPASSKGGGGS
rLLLLLLr
NameRGD peptide matrix
Length23
N-Terminal ModificationAcetylation
C-Terminal ModificationAmidation
Linear/ CyclicLinear
ChiralityMix
Chemical ModificationNone
Origin of PeptideSynthetic
Nature of Peptide/CargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site
MechanismCells attach themselves to the RGD sequences of the matrix via specific cell surface integrin receptors
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done.
EnhancerThis synthetic matrix consists of an RGD-containing peptide complexed with sodium hyalurohyaluronate in a sterile, nonpreserved viscous gel.
Properties of enhancerNot mentioned
ConcentrationNot mentioned
Incubation time>24 months
Tissue permeability (value with units)Mean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 61% (14 patients)
Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESCC(=O)NCC(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C
(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C
(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC[NH3])C(=O)NCC(=O)NCC(=O)NCC
(=O)NCC(=O)N[C@H](CO)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CC(C)C)C
(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)
N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N