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Details of TopicalPdb ID 1315

PRIMARY INFORMATION
ID1315
PMID2845208
Year1988
SequenceSYS-Nle-EHfRWGKPV
Name[Nle4, D-Phe7]-alpha-MSH
Length13
N-Terminal ModificationAcetylation
C-Terminal ModificationAmidation
Linear/ CyclicLinear
ChiralityMix
Chemical ModificationNle=Norleucine
Origin of PeptideDerived from α-MSH
Nature of Peptide/CargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes.
MechanismTopically applied melanotropin could activate cellular processes within follicular melanocytes leading to new eumelanin formation
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayFrog Skin Bioassay, radioimmunoassay and microscopy
EnhancerPEG cream vehicle was used as carrier
Properties of enhancerNot mentioned
ConcentrationFirst dissolved at 10-3M in distilled water and then diluted in a polyethylene glycol vehicle (26% PEG 400 and 74% PEG 3350, by weight) to 10-4M
Incubation time24 hours
Tissue permeability (value with units)Transdermal delivery of 0.05%
Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)
C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](Cc1nc[nH]c1)C
(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)
N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCC[NH3])
C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N