PRIMARY INFORMATION |
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ID | 1333 |
PMID | 2155969 |
Year | 1990 |
Sequence | SYS-Nle-EHfRWGKPV |
Name | (Nle4, D-Phe7)-a-MSH |
Length | 13 |
N-Terminal Modification | Acetylation |
C-Terminal Modification | Amidation |
Linear/ Cyclic | Linear |
Chirality | Mix |
Chemical Modification | Nle=Norleucine |
Origin of Peptide | Derived from α-MSH |
Nature of Peptide/Cargo | The analogue is superpotent, being 10- 1000 times more active than the native hormone, a-MSH, in several bioassays |
Mechanism | It causes follicular melanogenesis,the analogue caused a shift of follicular melanocytes from pheomelanogenesis (yellow melanin) to eumelanogenesis (dark brown/black melanin) in hair follicles. |
Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
Assay | Frog Skin Bioassay |
Enhancer | None |
Properties of enhancer | Not applicable |
Concentration | 100µ/100 mm2 for the smaller-sized permeation cell and 200µ/230 mm2 for the large-sized cell |
Incubation time | 24 hours |
Tissue permeability (value with units) | Head and neck(85.7%), Trunk(8.7%),Leg(25%) |
Tissue Sample | Stratum corneum of human skin samples (obtained from freshly excised surgical specimens) |
Ex vivo/In vivo/In vitro | in vitro |
SECONDARY INFORMATION |
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STRUCTURE | |
SMILES | N.A. |