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Details of TopicalPdb ID 1346

PRIMARY INFORMATION
ID1346
PMID1977237
Year1990
SequencepGlu-EDSG
NameEpidermal pentapeptide
Length5
N-Terminal ModificationFree
C-Terminal ModificationHydroxylation
Linear/ CyclicLinear
ChiralityL
Chemical ModificationpGlu= Pyroglutamic acid
Origin of PeptideSynthetic
Nature of Peptide/CargoIt induces a moderate but long-lasting inhibition of epidermal cell proliferation when given at low (picomol) doses but stimulates epidermal cell proliferation at higher doses
MechanismIt induces long-lasting oscillations in the epidermal mitotic rate and DNA synthesis.
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayColcemid-arrested mitoses and labelled cells were counted per 12 mm of interfollicular epidermis in 5 pm paraffin sections stationed with haematoxylin in the former and dipcoated with NTB 2 emulsion and incubated for 3 weeks at 0-4 ͦC for later. The statistical evaluations were made according to the Wilcoxon's rank sum test.
EnhancerNone
Properties of enhancerNot applicable
Concentration0.02% (wt/wt) EPP cream
Incubation time30 minutes
Tissue permeability (value with units)Initial increase in mitotic rate, peaking on day 2, from day 2 to day 10, mitotic rate was lower than normal.
Tissue SampleBack skin of female hairless mice (hr/hr)
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.