Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1361

PRIMARY INFORMATION
ID1361
PMID1373740
Year1992
SequenceEGKRGDACEG
NameTRAP analogue p514-523
Length10
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideHuman thrombin derivative
Nature of Peptide/CargoThromboplastin activation product of prothrombin with high clotting and esterase activity.
MechanismThey bind thrombin receptors and activate mitogenic signals.
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayHistological examination and numerical scoring of cellular and tissue parameters of wound healing and determining incisional breaking strength.
EnhancerNone
Properties of enhancerNot applicable
Concentration1.3 µg/cm
Incubation time14 days
Tissue permeability (value with units)Incisional breaking strength of 0.97±0.25 (ratio test/saline control)
Tissue SampleTwo parallel 6-cm full dermal incisions were cut through the backs of anesthetized and depilitated acclimatized adult male Harlan Sprague-Dawley rats. The incisions were closed with three interrupted sutures and treated on alternating sides with test peptide and control.
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCC[NH3])C(=O)N
[C@@H](CCCNC(=[NH2])N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N
[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC=O