ID | 1407 | |
PMID | 1689665 | |
Year | 1989 | |
Sequence | rPKPQQwFwLL | |
Name | Spantide | |
Length | 11 | |
N-Terminal Modification | Free | |
C-Terminal Modification | Amidation | |
Linear/ Cyclic | Linear | |
Chirality | Mix | |
Chemical Modification | None | |
Origin of Peptide | A tachykinin antagonist | |
Nature of Peptide/Cargo | Effectively prevents the miosis and the disruption of the blood-aqueous barrier consequent to ocular injury. | |
Mechanism | A tachykinin antagonist | |
Cargo Sequence/Structure | None | |
Name of cargo | Not applicable | |
Assay | Radioimmunoassay, HPLC | |
Enhancer | Samples were treated with two volumes of ice-cold acetone to precipitate proteins and subsequently dried and dissolved in chromatography Solvent | |
Properties of enhancer | Not mentioned | |
Concentration | 300nmol in 50µl 0.9% NaCl (applied 4 times in 15 minutes) | |
Incubation time | 180 minutes | |
Tissue permeability (value with units) | Systemic uptake corresponds to a serum concentration peak of 1*10-7M after 15 minutes and intraoccular uptake corresponded to a plateau at 1.3-1.5µg/ml for 90-240 minutes after completion of application giving an approximate concentration of 10m6 M in the aqueous humor. | |
Tissue Sample | Left eye of pigmented rabbits of either sex and weighing 2-3 kg | |
Ex vivo/In vivo/In vitro | in vivo | |
STRUCTURE |
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SMILES | N[C@H](CCCNC(=[NH2])N)C(=O)N1CCC [C@H]1C(=O)N[C@@H](CCCC[NH3])C(=O)N1CCC [C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC (=O)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C (=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12) C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H] (CC(C)C)C(=O)N |