Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1425

PRIMARY INFORMATION
ID1425
PMID2365569
Year1990
SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameVasoactive intestinal peptide (VIP)
Length28
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideVIP is a neuropeptide
Nature of Peptide/CargoPotent cAMP-dependent stimulus of both fluid and protein secretion from the rat and rabbit main lacrimal gland
MechanismVIP is a neuropeptide
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayTear film osmolarity
EnhancerThe osmolarity of the solution was 302 mOsm/1, and the pH was 7.4. Aliquots of peptide stock solutions were stored at -80°C until used
Properties of enhancerNot mentioned
Concentration2*10-8 M
Incubation time0minutes, 6 minutes and 16 minutes for osmolarity measurement
Tissue permeability (value with units)Osmolarity measurements: t=0 min., VIP/Buffer=330/314.5mOsm/l; t=16 min., VIP/Buffer=315/313.5mOsm/l
Tissue SampleEyes of male and female New Zealand white rabbits with closed lacrimal gland excretory duct
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C=O)CC(=O)N)CC(C)C)
[C@H](CC)C)CO)CC(=O)N)CC(C)C)Cc1ccc(cc1)O)CCCCN)
CCCCN)C(C)C)C)CCSC)CCC(=O)N)CCCCN)CCCNC
(=N)N)CC(C)C)CCCNC(=N)N)[C@H](O)C)Cc1ccc
(cc1)O)CC(=O)N)CC(=O)O)[C@H](O)C)Cc1ccccc1)
C(C)C)C)CC(=O)O)CO)Cc1[nH]cnc1