| ID | 1430 | |
| PMID | 2365569 | |
| Year | 1990 | |
| Sequence | HSDGTLTSELSRLRD RARLQRLLQGLL | |
| Name | Secretin | |
| Length | 27 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Amidation | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Adrenocorticotropic hormone | |
| Nature of Peptide/Cargo | Secretin stimulates the release of a watery bicarbonate solution from the pancreatic and bile duct epithelium. | |
| Mechanism | Adrenocorticotropic hormone | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Osmolarity and tear volume measurements | |
| Enhancer | The osmolarity of the solution was 302 mOsm/1, and the pH was 7.4. Aliquots of peptide stock solutions were stored at -80°C until used | |
| Properties of enhancer | Not mentioned | |
| Concentration | 2*10-5 M | |
| Incubation time | 0minutes, 6 minutes and 16 minutes for osmolarity measurement and 5-6 minutes for volume measurement | |
| Tissue permeability (value with units) | Caused decrease in tear film osmolarity, Tear volume: VIP/Buffer= 5.0±0.8µl/5.5±0.5µl | |
| Tissue Sample | Eyes of male and female New Zealand white rabbits with closed lacrimal gland excretory duct | |
| Ex vivo/In vivo/In vitro | in vivo | |
| STRUCTURE |
| |
| SMILES | N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C=O) CC(C)C)CC(C)C)CCC(=O)N)CC(C)C)CC(C)C)CCCNC(=N)N) CCC(=O)N)CC(C)C)CCCNC(=N)N)C)CCCNC(=N)N)CC (=O)O)CCCNC(=N)N)CC(C)C)CCCNC(=N)N)CO)CC (C)C)CCC(=O)O)CO)[C@H](O)C)CC(C)C)[C@H](O)C) CC(=O)O)CO)Cc1[nH]cnc1 | |