Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1431

PRIMARY INFORMATION
ID1431
PMID2365569
Year1990
SequenceHSQGTFTSDYSKYLD
SRRAQDFVQWLMNT
NameGlucagon
Length29
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideThe hormone is synthesized and secreted from alpha cells (α-cells) of the islets of Langerhans, which are located in the endocrine portion of the pancreas.
Nature of Peptide/CargoThe pancreas releases glucagon when the concentration of glucose in the bloodstream falls too low in order to raise glucose levels
MechanismThe hormone is synthesized and secreted from alpha cells (α-cells) of the islets of Langerhans, which are located in the endocrine portion of the pancreas.
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayTear film osmolarity
EnhancerThe osmolarity of the solution was 302 mOsm/1, and the pH was 7.4. Aliquots of peptide stock solutions were stored at -80°C until used
Properties of enhancerNot mentioned
Concentration2*10-6 M
Incubation time0minutes, 6 minutes and 16 minutes for osmolarity measurement
Tissue permeability (value with units)Osmolarity measurements: t=0 min., Glucagon/Buffer=311/312.5mOsm/l; t=6 min., Glucagon/Buffer=304/306.5mOsm/l; t=16 min., Glucagon/Buffer=305/307.5mOsm/l
Tissue SampleEyes of male and female New Zealand white rabbits with closed lacrimal gland excretory duct
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C=O)[C@H](O)C)CC(=O)N)CCSC)CC(C)C)Cc1c
[nH]c2c1cccc2)CCC(=O)N)C(C)C)Cc1ccccc1)CC
(=O)O)CCC(=O)N)C)CCCNC(=N)N)CCCNC(=N)N)CO)CC(=O)
O)CC(C)C)Cc1ccc(cc1)O)CCCCN)CO)Cc1ccc(cc1)O)CC
(=O)O)CO)[C@H](O)C)Cc1ccccc1)[C@H](O)C)CCC
(=O)N)CO)Cc1[nH]cnc1