Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1438

PRIMARY INFORMATION
ID1438
PMID3262039
Year1992
SequenceACDTATCVTHRLAGL
LSRSGGVVKNNFVPT
NVGSKAF
Nameα-CGRP (α-calcitonin gene-related peptide)
Length37
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideCGRP is encoded in the same gene as calcitonin and expressed in neural tissues by processing through a different mRNA pathway
Nature of Peptide/CargoSpecific binding sites for CGRP have been demonstrated both in the brain and in peripheral target tissues, where CGRP has been shown to act through a CAMP-dependent mechanism
MechanismCGRP is encoded in the same gene as calcitonin and expressed in neural tissues by processing through a different mRNA pathway
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayRadio-actively labelled microspheres were used to determine blood flow
EnhancerNot mentioned
Properties of enhancerNot mentioned
ConcentrationCGRP=0.5µg
Incubation time30 minutes
Tissue permeability (value with units)Regional blood flow in anterior uvea(iris+ciliary body): For CGRP it rose by 244.8±80.2mg/minute/whole tissue, For saline it rose by 33.8±16.2mg/minute/whole tissue
Tissue SampleEyes of New Zealand albino rabbits
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)NCC
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C=O)Cc1ccccc1)C)CCCCN)CO)C(C)C)CC(=O)N)[C@H](O)
C)CCC)C(C)C)Cc1ccccc1)CC(=O)N)CC(=O)N)CCCCN)
C(C)C)C(C)C)CO)CCCNC(=N)N)CO)CC(C)C)CC(C)C)C)
CC(C)C)CCCNC(=N)N)Cc1[nH]cnc1)[C@H]
(O)C)C(C)C)CS)[C@H](O)C)C)[C@H](O)C)CC(=O)O)CS)C