Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1583

PRIMARY INFORMATION
ID1583
PMID24637683
Year2014
SequenceKFFKKLKNSVKKRAK
KFFKKPRVIGVSIPF
NameOH-CATH30
Length30
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideNaturally occurs in King Cobra
Nature of Peptide/CargoCationic peptide of cathelicidin family. Exerts potent antibacterial activity, selective immunomodulatory properties and low toxicity to eukaryotic cells
MechanismNaturally occurs in King Cobra
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayTime kill assay, Clinical and histological examination, Measurement of bacterial burden
EnhancerP.aeruginosa 447 was used to induce bacterial keratitis
Properties of enhancerNot mentioned
Concentration20 µl drop of 1 mg/ml concentration of peptide and 20 µl drop of 1 mg/ml concentration of Levofloxacin
Incubation time1 hour
Tissue permeability (value with units)Mean clinical score: OH-CATH30-0.8; PBS-2.25; Levofloxacin-1.4 ; OH-CATH30+Levofloxacin-0.7, where, 0= clear;1= slight opacity partially or fully covering the pupil;2= slight opacity fully covering the anterior segment;3= dense opacity partially or fully covering the pupil and 4= dense opacity covering the anterior segment and corneal perforation
Tissue SampleCornea
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N2[C@H](C(=O)N[C@H](C=O)
Cc3ccccc3)CCC2)[C@H](CC)C)CO)C(C)C)[C@H](CC)C)C(C)C)
CCCNC(=N)N)CCC1)CCCCN)CCCCN)Cc1ccccc1)Cc1ccccc1)
CCCCN)CCCCN)C)CCCNC(=N)N)CCCCN)CCCCN)C(C)C)
CO)CC(=O)N)CCCCN)CC(C)C)CCCCN)CCCCN)Cc1ccccc1)
Cc1ccccc1)CCCCN