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Details of TopicalPdb ID 1587

PRIMARY INFORMATION
ID1587
PMID26724457
Year2016
SequenceVFLQ KYPHTHLVHQA
NameMstnF
Length15
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationHA (hyaluronate)conjugated
Origin of PeptideSynthetic peptide corresponds to sequence from 50 to 64 of the mature myostatin and conjugated to HA
Nature of Peptide/CargoNot mentioned
MechanismNot mentioned
Cargo Sequence/StructureNo cargo
Name of cargo
Not applicable
AssayFlow cytometery,two-photon microscopy, confocal microscopy
EnhancerNone
Properties of enhancerNot applicable
Concentration17kDa
Incubation time48 hours
Tissue permeability (value with units)Maximum cytokine release was seen on treatment.
Tissue Samplemdx mice
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N
[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N
[C@@H](CCCC[NH3])C(=O)N[C@@H](Cc1ccc(O)cc1)C
(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1nc[nH]c1)
C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNCN1)
C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)
N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](CCC(=O)N)C(=O)
N[C@@H](C)C=O