| ID | 1602 | |
| PMID | 25499919 | |
| Year | 2015 | |
| Sequence | HIITDPNMAEYL 4.18 | |
| Name | LP-12 (Linear Peptide) | |
| Length | 12 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Synthetic | |
| Nature of Peptide/Cargo | Not mentioned | |
| Mechanism | Not mentioned | |
| Cargo Sequence/Structure | CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C | |
| Name of cargo | Cyclosporine A (CsA) | |
| Assay | Tape-Stripping, Franz diffusion cells | |
| Enhancer | Ethanol/PBS,pH 7.4 | |
| Properties of enhancer | Not mentioned | |
| Concentration | 25mg/ml | |
| Incubation time | 24hrs | |
| Tissue permeability (value with units) | Approximately 11% of the applied CsA penetrated the skin. | |
| Tissue Sample | Porcine skin | |
| Ex vivo/In vivo/In vitro | in vitro | |
| STRUCTURE |
| |
| SMILES | N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H]([C@@H] (C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H] (C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O) N[C@@H](CC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H] (C)C(=O)N[C@@H](CCC(=O)O)C (=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C=O | |