|
PMID |
ASP cm-sirna ID |
ASP cm-sirna (As) |
Modification |
Modification position |
Inhibition / IC50 (mut) |
Inhibition / IC50 (wt) |
Unit |
Cell line |
Experimental method |
Target |
|
19412185 |
ASP cm-sirna_0001 |
GCTGCTGCTGCTGCTGCTG |
Uncharged Amide backbone, K:D-Lysine |
1*19 |
0.34 ± 0.03 |
1.2 ± 0.3 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0002 |
GCTGCTGCTGCTGCTGCTG |
Uncharged Amide backbone, K:D-Lysine |
1*19 |
2.1 ± 0.5 |
> 16 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0003 |
GCTGCTGCTGCTGCTGCTG |
Uncharged Amide backbone, K:D-Lysine,
R:D-Arginine |
1*19 |
0.33 ± 0.04 |
0.64 ± 0.08 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0004 |
GCTGCTGCTGCTGCTG |
Uncharged Amide backbone, K:D-Lysine |
1*16 |
0.39 ± 0.11 |
1.4 ± 0.3 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0005 |
GCTGCTGCTGCTG- |
Uncharged Amide backbone, K: D-Lysine |
1*13 |
0.47 ± 0.18 |
2.2 ± 0.4 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0006 |
GCTGCTGCTGGAAGGACTT |
Uncharged Amide backbone, K: D-Lysine |
1*19 |
0.018 ± 0.010 |
0.055 ± 0.023 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0007 |
GGCGGCTGTTGCTGCTGCT |
Uncharged Amide backbone, K:D-Lysine |
1*19 |
0.96 ± 0.13 |
4.8 ± 1.8 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0008 |
GCTGCTGCTGTTGCTGCTT |
Uncharged Amide backbone, K:D-Lysine |
1*19 |
0.018 ± 0.010 |
0.055 ± 0.023 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0009 |
ATAGGTCCCGCTGCTGCTG |
Uncharged Amide backbone, K:D-Lysine |
3,6,9,12,15,18 |
0.96 ± 0.13 |
4.8 ± 1.8 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0010 |
GCTGCTGCTGCTGCTGCTG |
Uncharged Amide backbone, K:D-Lysine |
1*19 |
0.58 ± 0.07 |
1.2 ± 0.4 |
µM |
GM04869 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0011 |
GCTGCTGCTGCTGCTGCTG |
Uncharged Amide backbone, K:D-Lysine |
1*19 |
2.3 ± 0.3 |
> 8 |
µM |
GM04869 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0012 |
GCTGCTGCTGCTGCTGCTG |
LNA*DNA bases |
3,6,9,12,15,18*1,2,4,5,7,8,10,11,13,14,16,17,19 |
0.017 ± 0.007 |
> 0.1 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0013 |
GCTGCTGCTGGAAGGACTT |
LNA*DNA bases |
3,6,9,12,15,18*1,2,4,5,7,8,10,11,13,14,16,17,19 |
0.018 ± 0.010 |
0.055 ± 0.023 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0014 |
GGCGGCTGTTGCTGCTGCT |
LNA*DNA bases |
3,6,9,12,15,18*1,2,4,5,7,8,10,11,13,14,16,17,19 |
0.086 ± 0.038 |
> 0.1 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0015 |
GCUGCUGCUGCUGCUGCUG |
s:Phosphorothioate |
2,4,6,8,10,12,14,16,18,20 |
0.012 ± 0.004 |
0.024 ± 0.009 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0016 |
GCUGCUGCUGGAAGGACUU |
s:Phosphorothioate |
2,4,6,8,10,12,14,16,18,20 |
0.018 ± 0.010 |
0.055 ± 0.023 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0017 |
GGCGGCUGUUGCUGCUGCU |
s:Phosphorothioate |
2,4,6,8,10,12,14,16,18,20 |
0.086 ± 0.038 |
> 0.1 |
µM |
GM04281 |
Western blot |
HTT |
|
19412185 |
ASP cm-sirna_0018 |
GAGGAAGAGGAGGAGGCCGA |
s:Phosphorothioate |
2,4,6,8,10,12,14,16,18,20 |
0.023 ± 0.032 |
>0.2 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0019 |
TCUGCUGCUGCUGCUGCUGAA |
s:Phosphorothioate*5'-VP:5-(E)-vinyl-Phosphonate*f:2'-Fluoro*2-O-Me:2-O-Methyl*2-MOE:2-Methyoxyethyl |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 * 20,21 |
0.08 ±0.01 |
>1 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0020 |
TCUGCUGCAGCUGCUGCUGAA |
s:Phosphorothioate*5'-VP:5-(E)-vinyl-Phosphonate*f:2-Fluoro*2-O-Me:2-O-Methyl*2-MOE:2-Methyoxyethyl |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 * 20,21 |
0.03±0.003 |
>1 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0021 |
TCUGCUGCUACUGCUGCUGAA |
s:Phosphorothioate*5'-VP:5-(E)-vinyl-Phosphonate*f:2-Fluoro*2-O-Me:2-O-Methyl*2-MOE:2-Methyoxyethyl |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 * 20,21 |
2.23±0.002 |
>1 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0022 |
TCUGCUGCUGCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
0.05±0.001 |
7.18±0.015 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0023 |
TCUACUGCUGCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
0.08 |
6.11 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0024 |
TCUGAUGCUGCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
1.72±0.002 |
>1 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0025 |
TCUGCAGCUGCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
ND |
ND |
ND |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0026 |
TCUGCUACUGCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
1.12±0.001 |
5.11 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0027 |
TCUGCUGAUGCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
0.04±0.001 |
0.29 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0028 |
TCUGCUGCAGCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
0.049±0.008 |
9.4 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0029 |
TCUGCUGCUACUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
1.78±0.035 |
>1 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0030 |
TCUGCUGCUUCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
1.53±0.002 |
>1 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0031 |
TCUGCUGCUGAUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
1.28±0.001 |
>1 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0032 |
TCUGCUGCUGCAGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
0.003 |
0.07 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0033 |
TCUGCUGCUGCUACUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
0.042 |
>1 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0034 |
TCUGCUGCUGCUGCUACUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
0.081 |
0.273 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0035 |
TCUGCUGCAACUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
0.063±0.005 |
>1 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0036 |
TCUGCUGCAAAUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
0.033±0.005 |
>1 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0037 |
TCUGCUGAAAAUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
11.8±0.01 |
>1 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0038 |
TCUACUGCUACUGCUACUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
0.223 |
>1 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0039 |
TCAGCUGUUGCUACUGUUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
ND |
ND |
ND |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0040 |
TGCUGCUGCUGCUGCUGCUAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
19.4 |
>100 |
µM |
GM04719 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0041 |
TCUGCUGCUGCUGCUGCUGAA |
s:Phosphorothioate*5'-VP:5-(E)-vinyl-Phosphonate*f:2-Fluoro*2-O-Me:2-O-Methyl*2-MOE:2-Methyoxyethyl |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 * 20,21 |
0.08 ±0.01 |
>1 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0042 |
TCUGCUGCAGCUGCUGCUGAA |
s:Phosphorothioate*5'-VP:5-(E)-vinyl-Phosphonate*f:2-Fluoro*2-O-Me:2-O-Methyl*2-MOE:2-Methyoxyethyl |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 * 20,21 |
0.03±0.003 |
>1 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0043 |
TCUGCUGCUACUGCUGCUGAA |
s:Phosphorothioate*5'-VP:5-(E)-vinyl-Phosphonate*f:2-Fluoro*2-O-Me:2-O-Methyl*2-MOE:2-Methyoxyethyl |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 * 20,21 |
2.23±0.002 |
>1 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0044 |
TCUGCUGCUGCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
0.05±0.001 |
7.18±0.015 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0045 |
TCUACUGCUGCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
0.08 |
6.11 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0046 |
TCUGAUGCUGCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
1.72±0.002 |
>1 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0047 |
TCUGCAGCUGCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
ND |
ND |
ND |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0048 |
TCUGCUACUGCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
1.12±0.001 |
5.11 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0049 |
TCUGCUGAUGCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
0.04±0.001 |
0.29 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0050 |
TCUGCUGCAGCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
0.049±0.008 |
9.4 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0051 |
TCUGCUGCUACUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
1.78±0.035 |
>1 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0052 |
TCUGCUGCUUCUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
1.53±0.002 |
>1 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0053 |
TCUGCUGCUGAUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
1.28±0.001 |
>1 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0054 |
TCUGCUGCUGCAGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
0.003 |
0.07 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0055 |
TCUGCUGCUGCUACUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
0.042 |
>1 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0056 |
TCUGCUGCUGCUGCUACUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
0.081 |
0.273 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0057 |
TCUGCUGCAACUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
0.063±0.005 |
>1 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0058 |
TCUGCUGCAAAUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
0.033±0.005 |
>1 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0059 |
TCUGCUGAAAAUGCUGCUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
11.8±0.01 |
>1 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0060 |
TCUACUGCUACUGCUACUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
0.223 |
>1 |
µM |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0061 |
TCAGCUGUUGCUACUGUUGAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 * 1,2,4,6,8,10,12,14,15,16,17,18,19,20
* 2,4,6,8,10,12,14,16,18 * 3,5,7,9,11,13,15,17,19 |
ND |
ND |
ND |
GM04281 |
Western blot |
HTT |
|
22939619 |
ASP cm-sirna_0062 |
TGCUGCUGCUGCUGCUGCUAA |
5-Phosphate*2-Methyoxyethyl*s:Phosphorothioate*2-Fluoro*2-O-Methyl |
1 * 1 *
1,2,4,6,8,10,12,14,15,16,17,18,19,20 * 2,4,6,8,10,12,14,16,18 *
3,5,7,9,11,13,15,17,19 |
19.4 |
>100 |
µM |
GM04281 |
Western blot |
HTT |
|
22336946 |
ASP cm-sirna_0063 |
GGAGCCCGACCACAGCUGG |
5′-Amine(sense) |
1 |
18 |
5 |
µM |
239T |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0064 |
GAGCCCGACCACAGCUGGC |
5′-Amine(sense) |
1 |
42 |
35 |
µM |
239T |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0065 |
AGCCCGACCACAGCUGGCA |
5′-Amine(sense) |
1 |
40 |
38 |
µM |
239T |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0066 |
CCGACCACAGCGGGCACAC |
5′-Amine(sense) |
1 |
70 |
48 |
µM |
239T |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0067 |
GACCACAGCUGGCACACCA |
5′-Amine(sense) |
1 |
0 |
35 |
µM |
239T |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0068 |
CGACCACAGCUGGCACACC |
5′-Amine(sense),5-Phosphate(As) |
1,1 |
38 |
50 |
µM |
239T |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0069 |
CCCGACCACAGCUGGCACA |
5′-Amine(sense),5-Phosphate(As) |
1,1 |
ND |
ND |
ND |
239T |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0070 |
ACAGCUGGCACACCAGGGC |
5′-Amine(sense),5-Phosphate(As) |
1,1 |
ND |
ND |
ND |
239T |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0071 |
CCUGGGAAUACCAGGCUUU |
5′-Amine(sense) |
1 |
0 |
21 |
µM |
239T |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0072 |
GCCUGGGAAUACCAGGCUU |
5′-Amine(sense) |
1 |
54 |
40 |
µM |
239T |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0073 |
CUGGGAGCCUGGGAAUACC |
5′-Amine(sense) |
1 |
40 |
45 |
µM |
239T |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0074 |
GCCUGGGAGCCUGGGAAUA |
5′-Amine(sense) |
1 |
3 |
8 |
µM |
239T |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0075 |
AACCCUGCCUGGGAGUCUGGG |
5′-Amine(sense) |
1 |
5 |
10 |
µM |
239T |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0076 |
GGAGCCCGACCACAGCUGG |
5′-Amine(sense) |
1 |
18 |
5 |
µM |
Dermal fibroblasts |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0077 |
GAGCCCGACCACAGCUGGC |
5′-Amine(sense) |
1 |
42 |
35 |
µM |
Dermal fibroblasts |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0078 |
AGCCCGACCACAGCUGGCA |
5′-Amine(sense) |
1 |
40 |
38 |
µM |
Dermal fibroblasts |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0079 |
CCGACCACAGCGGGCACAC |
5′-Amine(sense) |
1 |
70 |
48 |
µM |
Dermal fibroblasts |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0080 |
GACCACAGCUGGCACACCA |
5′-Amine(sense) |
1 |
0 |
35 |
µM |
Dermal fibroblasts |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0081 |
CGACCACAGCUGGCACACC |
5′-Amine(sense),5-Phosphate(As) |
1,1 |
38 |
50 |
µM |
Dermal fibroblasts |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0082 |
CCCGACCACAGCUGGCACA |
5′-Amine(sense),5-Phosphate(As) |
1,1 |
ND |
ND |
ND |
Dermal fibroblasts |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0083 |
ACAGCUGGCACACCAGGGC |
5′-Amine(sense),5-Phosphate(As) |
1,1 |
ND |
ND |
ND |
Dermal fibroblasts |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0084 |
CCUGGGAAUACCAGGCUUU |
5′-Amine(sense) |
1 |
0 |
21 |
µM |
Dermal fibroblasts |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0085 |
GCCUGGGAAUACCAGGCUU |
5′-Amine(sense) |
1 |
54 |
40 |
µM |
Dermal fibroblasts |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0086 |
CUGGGAGCCUGGGAAUACC |
5′-Amine(sense) |
1 |
40 |
45 |
µM |
Dermal fibroblasts |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0087 |
GCCUGGGAGCCUGGGAAUA |
5′-Amine(sense) |
1 |
3 |
8 |
µM |
Dermal fibroblasts |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0088 |
AACCCUGCCUGGGAGUCUGGG |
5′-Amine(sense) |
1 |
5 |
10 |
µM |
Dermal fibroblasts |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0089 |
GGAGCCCGACCACAGCUGG |
5′-Amine(sense) |
1 |
18 |
5 |
µM |
Keratinocytes |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0090 |
GAGCCCGACCACAGCUGGC |
5′-Amine(sense) |
1 |
42 |
35 |
µM |
Keratinocytes |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0091 |
AGCCCGACCACAGCUGGCA |
5′-Amine(sense) |
1 |
40 |
38 |
µM |
Keratinocytes |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0092 |
CCGACCACAGCGGGCACAC |
5′-Amine(sense) |
1 |
70 |
48 |
µM |
Keratinocytes |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0093 |
GACCACAGCUGGCACACCA |
5′-Amine(sense) |
1 |
0 |
35 |
µM |
Keratinocytes |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0094 |
CGACCACAGCUGGCACACC |
5′-Amine(sense),5-Phosphate(As) |
1,1 |
38 |
50 |
µM |
Keratinocytes |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0095 |
CCCGACCACAGCUGGCACA |
5′-Amine(sense),5-Phosphate(As) |
1,1 |
ND |
ND |
ND |
Keratinocytes |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0096 |
ACAGCUGGCACACCAGGGC |
5′-Amine(sense),5-Phosphate(As) |
1,1 |
ND |
ND |
ND |
Keratinocytes |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0097 |
CCUGGGAAUACCAGGCUUU |
5′-Amine(sense) |
1 |
0 |
21 |
µM |
Keratinocytes |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0098 |
GCCUGGGAAUACCAGGCUU |
5′-Amine(sense) |
1 |
54 |
40 |
µM |
Keratinocytes |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0099 |
CUGGGAGCCUGGGAAUACC |
5′-Amine(sense) |
1 |
40 |
45 |
µM |
Keratinocytes |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0100 |
GCCUGGGAGCCUGGGAAUA |
5′-Amine(sense) |
1 |
3 |
8 |
µM |
Keratinocytes |
DLR Assay |
COL7A1 |
|
22336946 |
ASP cm-sirna_0101 |
AACCCUGCCUGGGAGUCUGGG |
5′-Amine(sense) |
1 |
5 |
10 |
µM |
Keratinocytes |
DLR Assay |
COL7A1 |
|
22939618 |
ASP cm-sirna_0102 |
UUGUCUCUGGUCCUUACUU |
5'-MP:-5'-methylenephosphonate*2'-MOE |
1*1 |
ND |
>1 |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0103 |
UUGUCUCUGGUCCUUACUU |
5'-MP:-5'-methylenephosphonate*2'-MOE*s:Phosphorothioate |
1*1*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
>1 |
>1 |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0104 |
UUGUCUCUGGUCCUUACUU |
5'-MP:5'-methylenephosphonate*2'-MOE*s:Phosphorothioate*2'-fluororibose(2'-F) |
1*1*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
>1 |
ND |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0105 |
UUGUCUCUGGUCCUUACUU |
5'-MP:5'-methylenephosphonate*2'-MOE*s:Phosphorothioate |
1*1*12,13,14,15,16,17,18 |
0.39±0.009 |
ND |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0106 |
UUGUCUCUGGUCCUUACUU |
5'-MP:5'-methylenephosphonate*2'-MOE*s:Phosphorothioate*2'-fluororibose(2'-F) |
1*1*12,13,14,15,16,17,18*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
0.19±0.006 |
ND |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0107 |
UUGUCUCUGGUCCUUACUUAA |
5'-MP:5'-methylenephosphonate*2'-MOE*s:Phosphorothioate*2'-fluororibose(2'-F)*2'-MOE |
1*1*12,13,14,15,16,17,18*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17*18,19 |
0.05±0.002 |
ND |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0108 |
UUGUCUCUGGUCCUUACUUAA |
5'-MP:5'-methylenephosphonate*2'-MOE*s:Phosphorothioate*2'-fluororibose(2'-F)*2'-MOE*2'-OMe |
1*1*1,12,13,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
0.03±0.001 |
ND |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0109 |
UUGUCUCUGGUCCUUACUUAA |
5'-MP:5'-methylenephosphonate*2'-MOE*s:Phosphorothioate*2'-fluororibose(2'-F)*2'-MOE*2'-OMe |
1*1*1,2,4,6,8,10,12,14,15,16,17,18,19*2,4,6,8,10,12,14,16,18*1,20,21*3,5,7,9,11,13,15,17,19 |
0.02±0.004 |
ND |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0110 |
UUGUCUCUGGUCCUUACUU |
5′-OH |
1 |
0.005±0.0001 |
>0.9 |
µM |
MEF |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0111 |
UUGUCUCUGGUCCUUACUU |
5′-OH*s:Phosphorothioate |
1*12,13,14,15,16,17,18 |
0.004 |
>1 |
µM |
MEF |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0112 |
UUGUCUCUGGUCCUUACUU |
5′-OH*s:Phosphorothioate*2'-F |
1*12,13,14,15,16,17,18*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
0.007 |
>0.8 |
µM |
MEF |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0113 |
UUGUCUCUGGUCCUUACUUAA |
5′-OH*s:Phosphorothioate*2'-F*2'-MOE |
1*14,15,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*21* |
0.006±0.0001 |
>0.7 |
µM |
MEF |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0114 |
UUGUCUCUGGUCCUUACUUAA |
5′-OH*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19 |
0.009±0.0002 |
>0.6 |
µM |
MEF |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0115 |
UUGUCUCUGGUCCUUACUU |
5′-Ome |
1 |
0.27±0.009 |
>0.4 |
µM |
MEF |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0116 |
UUGUCUCUGGUCCUUACUUAA |
5′-Ome*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19 |
0.5 |
>0.3 |
µM |
MEF |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0117 |
UUGUCUCUGGUCCUUACUU |
5'-F |
1 |
0.006±0.0001 |
ND |
µM |
MEF |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0118 |
UUGUCUCUGGUCCUUACUUAA |
5'-F*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19 |
0.013±0.0004 |
ND |
µM |
MEF |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0119 |
UUGUCUCUGGUCCUUACUU |
5'deoxy(5'-H) |
1 |
0.007±0.0002 |
ND |
µM |
MEF |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0120 |
UUGUCUCUGGUCCUUACUUAA |
5'deoxy(5'-H)*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19 |
0.011±0.0004 |
ND |
µM |
MEF |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0121 |
UUGUCUCUGGUCCUUACUU |
5′-OH |
1 |
0.005±0.0001 |
>0.9 |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0122 |
UUGUCUCUGGUCCUUACUU |
5′-OH*s:Phosphorothioate |
1*12,13,14,15,16,17,18 |
0.004 |
>1 |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0123 |
UUGUCUCUGGUCCUUACUU |
5′-OH*s:Phosphorothioate*2'-F |
1*12,13,14,15,16,17,18*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
0.007 |
>0.8 |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0124 |
UUGUCUCUGGUCCUUACUUAA |
5′-OH*s:Phosphorothioate*2'-F*2'-MOE |
1*14,15,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*21* |
0.006±0.0001 |
>0.7 |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0125 |
TUGUCUCUGGUCCUUACUUAA |
5′-OH*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19 |
0.009±0.0002 |
>0.6 |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0126 |
UUGUCUCUGGUCCUUACUU |
5′-Ome |
1 |
0.27±0.009 |
>0.4 |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0127 |
TUGUCUCUGGUCCUUACUUAA |
5′-Ome*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19 |
0.5 |
>0.3 |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0128 |
UUGUCUCUGGUCCUUACUU |
5'-F |
1 |
0.006±0.0001 |
ND |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0129 |
TUGUCUCUGGUCCUUACUUAA |
5'-F*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19 |
0.013±0.0004 |
ND |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0130 |
UUGUCUCUGGUCCUUACUU |
5'deoxy(5'-H) |
1 |
0.007±0.0002 |
ND |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0131 |
TUGUCUCUGGUCCUUACUUAA |
5'deoxy(5'-H)*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19 |
0.011±0.0004 |
ND |
µM |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0132 |
TUGUCUCUGGUCCUUACUUAA |
5'-MP:5'-5'-methylenephosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
0.003 |
ND |
µM |
Hepatocytes |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0133 |
TUGUCUCUGGUCCUUACUUAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
0.011 |
ND |
µM |
Hepatocytes |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0134 |
TGAACAUUGGAAUAGUUUCAA |
5'-P:-5'-Phosphate*2'-MOE*s:Phosphorothioate*2'-fluororibose(2'-F)*2'-MOE*2'-OMe |
1*1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19 |
0.001 |
ND |
µM |
Hepatocytes |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0135 |
TGAACAUUGGAAUAGUUUCAA |
5'-MP:5'-methylenephosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
0.013 |
ND |
µM |
Hepatocytes |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0136 |
TGAACAUUGGAAUAGUUUCAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
0.004 |
ND |
µM |
Hepatocytes |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0137 |
TUAUCUAUAAUGAUCAGGUAA |
5'-P:5'-Phosphate*2'-MOE*s:Phosphorothioate*2'-fluororibose(2'-F)*2'-MOE*2'-OMe |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19 |
0.001 |
ND |
µM |
Hepatocytes |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0138 |
TUAUCUAUAAUGAUCAGGUAA |
5'-MP:5'-methylenephosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
0.007 |
ND |
µM |
Hepatocytes |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0139 |
TUAUCUAUAAUGAUCAGGUAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
0.001 |
ND |
µM |
Hepatocytes |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0140 |
TUAUCUAUAAUGAUCAGGUAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome*C10 |
1*2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19*8 |
0.002 |
ND |
µM |
Hepatocytes |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0141 |
TUAUCUAUAAUGAUCAGGUAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome*C16 |
1*2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19*8 |
0.01 |
ND |
µM |
Hepatocytes |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0142 |
TAUCAAUGUAUUGGUUAAAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
>1 |
ND |
µM |
Hepatocytes |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0143 |
TUAAGACUUGAGAUGAUCCAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
0.002 |
ND |
µM |
Hepatocytes |
qRT_PCR |
Factor VII |
|
22939618 |
ASP cm-sirna_0144 |
TAUGAGAACAUACUUUCCCAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
0.002 |
ND |
µM |
Hepatocytes |
qRT_PCR |
ApoCIII |
|
22939618 |
ASP cm-sirna_0145 |
TUGUCUCUGGUCCUUACUUAA |
5'-MP:5'-5'-methylenephosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
20 |
ND |
% |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0146 |
TUGUCUCUGGUCCUUACUUAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
25 |
ND |
% |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0147 |
TGAACAUUGGAAUAGUUUCAA |
5'-P:-5'-Phosphate*2'-MOE*s:Phosphorothioate*2'-fluororibose(2'-F)*2'-MOE*2'-OMe |
1*1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19 |
ND |
ND |
% |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0148 |
TGAACAUUGGAAUAGUUUCAA |
5'-MP:5'-methylenephosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
18 |
ND |
% |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0149 |
TGAACAUUGGAAUAGUUUCAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
58 |
ND |
% |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0150 |
TUAUCUAUAAUGAUCAGGUAA |
5'-P:5'-Phosphate*2'-MOE*s:Phosphorothioate*2'-fluororibose(2'-F)*2'-MOE*2'-OMe |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19 |
5 |
ND |
% |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0151 |
TUAUCUAUAAUGAUCAGGUAA |
5'-MP:5'-methylenephosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
38 |
ND |
% |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0152 |
TUAUCUAUAAUGAUCAGGUAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
55 |
ND |
% |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0153 |
TUAUCUAUAAUGAUCAGGUAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome*C10 |
1*2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19*8 |
50 |
ND |
% |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0154 |
TUAUCUAUAAUGAUCAGGUAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome*C16 |
1*2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*1,20,21*1,3,5,7,9,11,13,15,17,19*8 |
78 |
ND |
% |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0155 |
TAUCAAUGUAUUGGUUAAAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
10 |
ND |
% |
Transgenic mouse model |
qRT_PCR |
PTEN |
|
22939618 |
ASP cm-sirna_0156 |
TUAAGACUUGAGAUGAUCCAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
45 |
ND |
% |
Transgenic mouse model |
qRT_PCR |
Factor VII |
|
22939618 |
ASP cm-sirna_0157 |
TAUGAGAACAUACUUUCCCAA |
5'-VP:5'-E-vinylphosphonate*s:Phosphorothioate*2'-F*2'-MOE*2'-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*2,4,6,8,10,12,14,16,18*20,21*1,3,5,7,9,11,13,15,17,19 |
70 |
ND |
% |
Transgenic mouse model |
qRT_PCR |
ApoCIII |
|
21028906 |
ASP cm-sirna_0158 |
GCTGCTGCTGCTGCTGCTG |
LNA |
3,6,9,12,15,18 |
0.4±0.07 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0159 |
GCTGCTGCTGCTGCTGCTG |
LNA |
1,4,7,10,13,16,19 |
0.3±0.011 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0160 |
GCTGCTGCTGCTGCTGCTG |
LNA |
2,5,8,11,14,17 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0161 |
CTGCTGCTGCTGCTGCTGC |
LNA |
2,5,8,11,14,17 |
0.64±0.026 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0162 |
CTGCTGCTGCTGCTGCTGC |
LNA |
3,6,9,12,15,18 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0163 |
TGCTGCTGCTGCTGCTGCT |
LNA |
1,4,7,10,13,16,19 |
0.27±0.09 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0164 |
TGCTGCTGCTGCTGCTGCT |
LNA |
3,6,9,12,15,18 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0165 |
GCTGCTGCTGCTGCTGCTGCTG |
LNA |
3,6,9,12,15,18,21 |
0.37±0.011 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0166 |
GCTGCTGCTGCTGCTG |
LNA |
3,6,9,12,15 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0167 |
GCTGCTGCTGCTG |
LNA |
3,6,9,12 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0168 |
GCTGCTGCTGCTGCTGCTG |
LNA |
1,2,3,4,16,17,18,19 |
0.69±0.028 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0169 |
GCTGCTGCTGCTGCTGCTG |
LNA |
3,6,9,12,15,18 |
0.4±0.07 |
>1 |
µM |
GM04717 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0170 |
GCTGCTGCTGCTGCTGCTG |
LNA |
1,4,7,10,13,16,19 |
0.3±0.011 |
>1 |
µM |
GM04717 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0171 |
GCTGCTGCTGCTGCTGCTG |
LNA |
2,5,8,11,14,17 |
>1 |
>1 |
µM |
GM04717 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0172 |
CTGCTGCTGCTGCTGCTGC |
LNA |
2,5,8,11,14,17 |
0.64±0.026 |
>1 |
µM |
GM04717 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0173 |
CTGCTGCTGCTGCTGCTGC |
LNA |
3,6,9,12,15,18 |
>1 |
>1 |
µM |
GM04717 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0174 |
TGCTGCTGCTGCTGCTGCT |
LNA |
1,4,7,10,13,16,19 |
0.27±0.09 |
>1 |
µM |
GM04717 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0175 |
TGCTGCTGCTGCTGCTGCT |
LNA |
3,6,9,12,15,18 |
>1 |
>1 |
µM |
GM04717 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0176 |
GCTGCTGCTGCTGCTGCTGCTG |
LNA |
3,6,9,12,15,18,21 |
0.37±0.011 |
>1 |
µM |
GM04717 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0177 |
GCTGCTGCTGCTGCTG |
LNA |
3,6,9,12,15 |
>1 |
>1 |
µM |
GM04717 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0178 |
GCTGCTGCTGCTG |
LNA |
3,6,9,12 |
>1 |
>1 |
µM |
GM04717 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0179 |
GCTGCTGCTGCTGCTGCTG |
LNA |
1,2,3,4,16,17,18,19 |
0.69±0.028 |
>1 |
µM |
GM04717 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0180 |
GCUGCUGCUGCUGCUGCUG |
cEt:5'-cEtbridgednucleicacid |
3,6,9,12,15,18 |
0.33±0.007 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0181 |
GCTGCTGCTGCTGCTGCTG |
carba-LNA |
2,5,8,11,14,17 |
0.15±0.008 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0182 |
GCTGCTGCTGCTGCTGCTG |
ENA:ethylenenucleicacid |
3,6,9,12,15,18 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0183 |
CTGCTGCTGCTGCTGCTGC |
ENA:ethylenenucleicacidonends |
1,2,3,4,16,17,18,19 |
0.27±0.007 |
0.49±0.011 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0184 |
GCTGCTGCTGCTGCTGCTG |
2'-MOE |
1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0185 |
GCUGCUGCUGCUGCUGCUG |
2'-MOE*cEt:5'-cEtbridgednucleicacid |
1,2,4,5,7,8,10,11,13,14,16,17,19*3,6,9,12,15,18 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0186 |
GCTGCTGCTGCTGCTGCTG |
2'F-ANA:2'-flouroarabinonucleicacid |
3,6,9,12,15,18 |
µM |
GM042081 |
Western blot |
HTT |
||
|
21028906 |
ASP cm-sirna_0187 |
GCUGCUGCUGCUGCUGCUG |
2'F-RNA:2'-flouroribonucleicacid |
3,6,9,12,15,18 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0188 |
GCUGCUGCUGCUGCUGCUG |
2'F-RNA:2'-flouroribonucleicacid |
2,4,5,6,14,15,17,18 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0189 |
GCUGCUGCUGCUGCUGCUG |
2'F-RNA:2'-flouroribonucleicacid |
1,2,3,4,5,6,15,16,17,18 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0190 |
GCUGCUGCUGCUGCUGCUG |
2'F-RNA:2'-flouroribonucleicacid |
1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0191 |
GCTGCUGCTGCUGCTGCUG |
2'F-ANA:2'-flouroarabinonucleicacid |
4,5,6,10,11,12,16,17,18 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0192 |
GCTGCTGCTGCTGCTGCTG |
2'F-ANA:2'-flouroarabinonucleicacid |
1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0193 |
GCTGCTGCTGCTGCTGCTG |
LNA*s:Phosphorothioate |
3,6,9,12,18*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
0.14±0.006 |
0.87±0.025 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0194 |
GCUGCUGCUGCUGCUGCUG |
cEt:5'-cEtbridgednucleicacid*s:Phosphorothioate |
3,6,9,12,18*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
0.16±0.005 |
0.64±0.020 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0195 |
GCTGCTGCTGCTGCTGCTG |
2'-MOE*s:Phosphorothioate |
1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
0.60±0.002 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0196 |
GCUGCUGCUGCUGCUGCUG |
cEt:5'-cEtbridgednucleicacid*s:Phosphorothioate*2'-MOE |
3,6,9,12,18*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19*1,2,4,5,7,8,10,11,13,14,16,17 |
>1 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0197 |
GmCUGCUGCUGCUGCUGCTG |
2'F-ANA:2'-flouroarabinonucleicacid*2'-MOE*s:Phosphorothioate |
3,4,5,6,7,8,9,10,11,12,13,14,15,16*1,2,18,19*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
0.34±0.009 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
21028906 |
ASP cm-sirna_0198 |
GCTGCTGCTGCTGCTGCTG |
carba-LNA*s:Phosphorothioate |
2,5,8,11,14,17*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
0.23±0.007 |
>1 |
µM |
GM042081 |
Western blot |
HTT |
|
17940007 |
ASP cm-sirna_0199 |
UUCAUCAGCUUUUCCAGGGUC--CCC
UGGAAAAGCUGAUGACGG-Chol |
cholesterol-conjugated(cc)sensesiRNA*s:Phosphorothioate |
19(s)*1,18,19(As) |
60 |
70 |
% |
Transgenic mouse model |
Western blot |
HTT |
|
11809726 |
ASP cm-sirna_0200 |
CUGGAUGAGGAACAGCAACCUU:GGUUGCUGUUCCUCAUCCAGGA |
5'-P:-5'-Phosphate |
1(As),1(s) |
60 |
20 |
% |
S2 |
Northern blot |
AR |
|
11809726 |
ASP cm-sirna_0201 |
GAGUGAAUACCACGACGAUUUC:AAUCGUCGUGGUAUUCACUCCA |
5'-P:-5'-Phosphate |
1(As),1(s) |
45 |
20 |
% |
S2 |
Northern blot |
AR |
|
11809726 |
ASP cm-sirna_0202 |
GCAAGCUGACCCUGAAGUUCAU:GAACUUCAGGGUCAGCUUGCCG |
5'-P:-5'-Phosphate |
1(As),1(s) |
20 |
5 |
% |
S2 |
Northern blot |
AR |
|
11809726 |
ASP cm-sirna_0203 |
GCUCAAGGAUGGAAGUGCAGUU:CUGCACUUCCAUCCUUGAGCUU |
5'-P:-5'-Phosphate |
1(As),1(s) |
80 |
30 |
% |
S2 |
Northern blot |
AR |
|
11809726 |
ASP cm-sirna_0204 |
CUGGAUGAGGAACAGCAACCUU:GGUUGCUGUUCCUCAUCCAGGA |
5'-P:-5'-Phosphate |
1(As),1(s) |
70 |
10 |
% |
HEK293 |
Northern blot |
AR |
|
11809726 |
ASP cm-sirna_0205 |
GAGUGAAUACCACGACGAUUUC:AAUCGUCGUGGUAUUCACUCCA |
5'-P:-5'-Phosphate |
1(As),1(s) |
50 |
20 |
% |
HEK293 |
Northern blot |
AR |
|
11809726 |
ASP cm-sirna_0206 |
GCAAGCUGACCCUGAAGUUCAU:GAACUUCAGGGUCAGCUUGCCG |
5'-P:-5'-Phosphate |
1(As),1(s) |
23 |
5 |
% |
HEK293 |
Northern blot |
AR |
|
11809726 |
ASP cm-sirna_0207 |
GCUCAAGGAUGGAAGUGCAGUU:CUGCACUUCCAUCCUUGAGCUU |
5'-P:-5'-Phosphate |
1(As),1(s) |
85 |
30 |
% |
HEK293 |
Northern blot |
AR |
|
22859208 |
ASP cm-sirna_0208 |
GCGGTCAGCGATCCCAGGGT |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
44 |
20 |
% |
HepG2 |
RT-PCR |
hACTA1 |
|
22859208 |
ASP cm-sirna_0209 |
GGGAAGCGAGGCTTCACTTG |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
60 |
28 |
% |
HepG2 |
RT-PCR |
hACTA1 |
|
22859208 |
ASP cm-sirna_0210 |
CAGGGCTTTGTTTCGAAAAA |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
43 |
ND |
% |
HepG2 |
RT-PCR |
hACTA1 |
|
22859208 |
ASP cm-sirna_0211 |
CCATTTTCTTCCACAGGGCT |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
28 |
10 |
% |
HepG2 |
RT-PCR |
hACTA1 |
|
22859208 |
ASP cm-sirna_0212 |
CAGAATGACTTTAATGCTTC |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
18 |
93 |
% |
HepG2 |
RT-PCR |
hACTA1 |
|
22859208 |
ASP cm-sirna_0213 |
GGGTCAGCTGCCAATGCTAG |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
60 |
40 |
% |
HepG2 |
RT-PCR |
Malat1 |
|
22859208 |
ASP cm-sirna_0214 |
CGGTGCAAGGCTTAGGAATT |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
ND |
ND |
ND |
HepG2 |
RT-PCR |
Malat1 |
|
22859208 |
ASP cm-sirna_0215 |
CTGCTAGCCTCTGGATTTGA |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
ND |
96 |
% |
HepG2 |
RT-PCR |
Pten |
|
22859208 |
ASP cm-sirna_0216 |
GCTTCAGTCATGACTTCCTT |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
80 |
82 |
% |
HepG2 |
RT-PCR |
Srb1 |
|
22859208 |
ASP cm-sirna_0217 |
CCTTCCCTGAAGGTTCCTCC |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
ND |
20 |
% |
HepG2 |
RT-PCR |
NA |
|
22859208 |
ASP cm-sirna_0218 |
TAGTGCGGACCTACCCACGA |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
10 |
5 |
% |
HepG2 |
RT-PCR |
NA |
|
22859208 |
ASP cm-sirna_0219 |
CGGAGCGGTTGTGAACTGGC |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
56 |
34 |
% |
HepG2 |
RT-PCR |
hDMPK |
|
22859208 |
ASP cm-sirna_0220 |
GCGGTCAGCGATCCCAGGGT |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
30 |
20 |
% |
HepG2 |
Flourescence microscopy |
hACTA1 |
|
22859208 |
ASP cm-sirna_0221 |
GGGAAGCGAGGCTTCACTTG |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
67 |
21 |
% |
HepG2 |
Flourescence microscopy |
hACTA1 |
|
22859208 |
ASP cm-sirna_0222 |
CAGGGCTTTGTTTCGAAAAA |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
50 |
10 |
% |
HepG2 |
Flourescence microscopy |
hACTA1 |
|
22859208 |
ASP cm-sirna_0223 |
CCATTTTCTTCCACAGGGCT |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
20 |
0 |
% |
HepG2 |
Flourescence microscopy |
hACTA1 |
|
22859208 |
ASP cm-sirna_0224 |
CAGAATGACTTTAATGCTTC |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
ND |
93 |
% |
HepG2 |
Flourescence microscopy |
hACTA1 |
|
22859208 |
ASP cm-sirna_0225 |
GGGTCAGCTGCCAATGCTAG |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
44 |
12 |
% |
HepG2 |
Flourescence microscopy |
Malat1 |
|
22859208 |
ASP cm-sirna_0226 |
CGGTGCAAGGCTTAGGAATT |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
ND |
ND |
% |
HepG2 |
Flourescence microscopy |
Malat1 |
|
22859208 |
ASP cm-sirna_0227 |
CTGCTAGCCTCTGGATTTGA |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
ND |
96 |
% |
HepG2 |
Flourescence microscopy |
Pten |
|
22859208 |
ASP cm-sirna_0228 |
GCTTCAGTCATGACTTCCTT |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
80 |
82 |
% |
HepG2 |
Flourescence microscopy |
Srb1 |
|
22859208 |
ASP cm-sirna_0229 |
CCTTCCCTGAAGGTTCCTCC |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
ND |
20 |
% |
HepG2 |
Flourescence microscopy |
NA |
|
22859208 |
ASP cm-sirna_0230 |
TAGTGCGGACCTACCCACGA |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
ND |
ND |
% |
HepG2 |
Flourescence microscopy |
NA |
|
22859208 |
ASP cm-sirna_0231 |
CGGAGCGGTTGTGAACTGGC |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
ND |
ND |
% |
HepG2 |
Flourescence microscopy |
hDMPK |
|
22859208 |
ASP cm-sirna_0232 |
GCGGTCAGCGATCCCAGGGT |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
45 |
10 |
% |
HAS-LR mice |
Flourescence microscopy |
hACTA1 |
|
22859208 |
ASP cm-sirna_0233 |
GGGAAGCGAGGCTTCACTTG |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
46 |
20 |
% |
HAS-LR mice |
Flourescence microscopy |
hACTA1 |
|
22859208 |
ASP cm-sirna_0234 |
CAGGGCTTTGTTTCGAAAAA |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
33 |
10 |
% |
HAS-LR mice |
Flourescence microscopy |
hACTA1 |
|
22859208 |
ASP cm-sirna_0235 |
CCATTTTCTTCCACAGGGCT |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
40 |
18 |
% |
HAS-LR mice |
Flourescence microscopy |
hACTA1 |
|
22859208 |
ASP cm-sirna_0236 |
CAGAATGACTTTAATGCTTC |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
20 |
89 |
% |
HAS-LR mice |
Flourescence microscopy |
hACTA1 |
|
22859208 |
ASP cm-sirna_0237 |
GGGTCAGCTGCCAATGCTAG |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
56 |
20 |
% |
HAS-LR mice |
Flourescence microscopy |
Malat1 |
|
22859208 |
ASP cm-sirna_0238 |
CGGTGCAAGGCTTAGGAATT |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
ND |
ND |
ND |
HAS-LR mice |
Flourescence microscopy |
Malat1 |
|
22859208 |
ASP cm-sirna_0239 |
CTGCTAGCCTCTGGATTTGA |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
ND |
96 |
% |
HAS-LR mice |
Flourescence microscopy |
Pten |
|
22859208 |
ASP cm-sirna_0240 |
GCTTCAGTCATGACTTCCTT |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
80 |
82 |
% |
HAS-LR mice |
Flourescence microscopy |
Srb1 |
|
22859208 |
ASP cm-sirna_0241 |
CCTTCCCTGAAGGTTCCTCC |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
ND |
20 |
% |
HAS-LR mice |
Flourescence microscopy |
NA |
|
22859208 |
ASP cm-sirna_0242 |
TAGTGCGGACCTACCCACGA |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
ND |
ND |
ND |
HAS-LR mice |
Flourescence microscopy |
NA |
|
22859208 |
ASP cm-sirna_0243 |
CGGAGCGGTTGTGAACTGGC |
2'-MOE*s:Phosphorothioate*5'deoxy(5'-H) |
1,2,3,4,5,16,17,18,19,20*1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20*6,7,8,9,10,11,12,13,14,15,16 |
ND |
ND |
ND |
HAS-LR mice |
Flourescence microscopy |
hDMPK |
|
10666454 |
ASP cm-sirna_0244 |
CGACGCGATACCGCTTCTGC |
ODNs:Antisenseoligodeoxynucleotides |
11 |
5 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0245 |
CGATACCGCTTCTGCCGGAC |
ODNs:Antisenseoligodeoxynucleotides |
5 |
<8 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0246 |
CACGTCGACGCGATACCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
ND |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0247 |
CGTCGACGCGATACCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
ND |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0248 |
GTCGACGCGATACCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
<2 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0249 |
TCGACGCGATACCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
3 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0250 |
ACGTCGACGCGATACCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
7 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0251 |
CGTCGACGCGATACCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
4 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0252 |
GTCGACGCGATACCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
>4 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0253 |
TCGACGCGATACCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
>1 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0254 |
TCGACGCGATACCGCTT |
ODNs:Antisenseoligodeoxynucleotides |
11 |
>8 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0255 |
CGACGCGATACCGCTT |
ODNs:Antisenseoligodeoxynucleotides |
11 |
>8 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0256 |
CGACGCGATGCCGCTTCTGC |
ODNs:Antisenseoligodeoxynucleotides |
11 |
6 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0257 |
CGATGCCGCTTCTGCCGGAC |
ODNs:Antisenseoligodeoxynucleotides |
5 |
<3 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0258 |
CACGTCGACGCGATGCCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
<4 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0259 |
CGTCGACGCGATGCCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
ND |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0260 |
GTCGACGCGATGCCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
>8 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0261 |
TCGACGCGATGCCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
>8 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0262 |
ACGTCGACGCGATGCCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
ND |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0263 |
CGTCGACGCGATGCCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
6 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0264 |
GTCGACGCGATGCCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
ND |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0265 |
TCGACGCGATGCCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
ND |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0266 |
TCGACGCGATGCCGCTT |
ODNs:Antisenseoligodeoxynucleotides |
11 |
ND |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0267 |
CGACGCGATGCCGCTT |
ODNs:Antisenseoligodeoxynucleotides |
11 |
>8 |
ND |
µM |
MiaPaca II |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0268 |
CGACGCGATACCGCTTCTGC |
ODNs:Antisenseoligodeoxynucleotides |
11 |
5 |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0269 |
CGATACCGCTTCTGCCGGAC |
ODNs:Antisenseoligodeoxynucleotides |
5 |
ND |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0270 |
CACGTCGACGCGATACCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
ND |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0271 |
CGTCGACGCGATACCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
ND |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0272 |
GTCGACGCGATACCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
<2 |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0273 |
TCGACGCGATACCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
>8 |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0274 |
ACGTCGACGCGATACCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
ND |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0275 |
CGTCGACGCGATACCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
>8 |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0276 |
GTCGACGCGATACCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
ND |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0277 |
TCGACGCGATACCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
ND |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0278 |
TCGACGCGATACCGCTT |
ODNs:Antisenseoligodeoxynucleotides |
11 |
>8 |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0279 |
CGACGCGATACCGCTT |
ODNs:Antisenseoligodeoxynucleotides |
11 |
>8 |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0280 |
CGACGCGATGCCGCTTCTGC |
ODNs:Antisenseoligodeoxynucleotides |
11 |
ND |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0281 |
CGATGCCGCTTCTGCCGGAC |
ODNs:Antisenseoligodeoxynucleotides |
5 |
ND |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0282 |
CACGTCGACGCGATGCCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
ND |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0283 |
CGTCGACGCGATGCCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
ND |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0284 |
GTCGACGCGATGCCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
>8 |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0285 |
TCGACGCGATGCCGCT |
ODNs:Antisenseoligodeoxynucleotides |
15 |
3 |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0286 |
ACGTCGACGCGATGCCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
ND |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0287 |
CGTCGACGCGATGCCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
>8 |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0288 |
GTCGACGCGATGCCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
ND |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0289 |
TCGACGCGATGCCGC |
ODNs:Antisenseoligodeoxynucleotides |
14 |
ND |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0290 |
TCGACGCGATGCCGCTT |
ODNs:Antisenseoligodeoxynucleotides |
11 |
>8 |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
10666454 |
ASP cm-sirna_0291 |
CGACGCGATGCCGCTT |
ODNs:Antisenseoligodeoxynucleotides |
11 |
>8 |
ND |
µM |
15PC3 |
Northern blot |
POLR2A |
|
12527766 |
ASP cm-sirna_0292 |
UUUGUAGUGCCUGAAGCCG |
s:Phosphorothioate |
1,19 |
82 |
10 |
% |
HaCaT |
Northern blot |
hTF |
|
12527766 |
ASP cm-sirna_0293 |
UUUGUAGUGCCUGAAGCCG |
s:Phosphorothioate |
17,18,19 |
88 |
10 |
% |
HaCaT |
Northern blot |
hTF |
|
12527766 |
ASP cm-sirna_0294 |
UUUGUAGUGCCUGAAGCCG |
s:Phosphorothioate |
1,2,3,17,18,19 |
90 |
10 |
% |
HaCaT |
Northern blot |
hTF |
|
12527766 |
ASP cm-sirna_0295 |
UUUGUAGUGCCUGAAGCCG |
s:Phosphorothioate |
1,2,3,16,17,18,19 |
78 |
10 |
% |
HaCaT |
Northern blot |
hTF |
|
12527766 |
ASP cm-sirna_0296 |
UUUGUAGUGCCUGAAGCCG |
2'-Ome |
1,19 |
75 |
10 |
% |
HaCaT |
Northern blot |
hTF |
|
12527766 |
ASP cm-sirna_0297 |
UUUGUAGUGCCUGAAGCGC |
2'-Ome |
18,19 |
78 |
10 |
% |
HaCaT |
Northern blot |
hTF |
|
12527766 |
ASP cm-sirna_0298 |
UAUUUGUAGUGCCUGAAGC |
2'-Ome |
1,2,18,19 |
79 |
10 |
% |
HaCaT |
Northern blot |
hTF |
|
12527766 |
ASP cm-sirna_0299 |
UAUUUGUAGUGCCUGAAGC |
2'-Ome |
1,2,16,17,18,19 |
75 |
10 |
% |
HaCaT |
Northern blot |
hTF |
|
12527766 |
ASP cm-sirna_0300 |
UAUUUGUAGUGCCUGAAGC |
2'-Allyl |
1,19 |
80 |
10 |
% |
HaCaT |
Northern blot |
hTF |
|
12527766 |
ASP cm-sirna_0301 |
UUUGUAGUGCCUGAAGCGC |
2'-Allyl |
18,19 |
72 |
10 |
% |
HaCaT |
Northern blot |
hTF |
|
23887934 |
ASP cm-sirna_0302 |
CGACGACGACGACGACGAC |
2'-Ome |
1,4,7,10,13,16,19 |
ND |
ND |
ND |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0303 |
CGACGACGAUGACGACGAC |
2'-Ome |
1,4,7,10,13,16,19 |
ND |
ND |
ND |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0304 |
CGACGACGACUACGACGAC |
2'-Ome |
1,4,7,10,13,16,19 |
ND |
ND |
ND |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0305 |
UGCUGCUGCY34GCUGCUGCU:ACGACGACGACGACGACGA |
2'-Ome*Abasicsite(2R,3S,4S)-2-hydroxy-methyl-4-methoxytetrahydrofuaran-3-ol(pentafuranoseabasicwith2-OMe,Y34) |
2,5,7,10,13,16,18(sense),11(As)*10(As) |
ND |
ND |
ND |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0306 |
UGCUGCUGCY33GCUGCUGCU:ACGACGACGACGACGACGA |
2'-Ome*(2R,3S)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol(hexapyranoseabasicmoiety,Y33) |
2,5,7,10,13,16(sense),11(As)*10(As) |
ND |
ND |
ND |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0307 |
GCUGCUGCY34GCUGCUGCUG:CGACGACGACGACGACGAC |
2'-Ome*Abasicsite(2R,3S,4S)-2-hydroxy-methyl-4-methoxytetrahydrofuaran-3-ol(pentafuranoseabasicwith2-OMe,Y34) |
1,4,7,10,12,14,17(sense),12(As)*11(As) |
.003. ± 0.0004 |
0.075±0.03 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0308 |
GCUGCUGCUY34CUGCUGCUG:CGACGACGAUGACGACGAC |
2'-Ome*Abasicsite(2R,3S,4S)-2-hydroxy-methyl-4-methoxytetrahydrofuaran-3-ol(pentafuranoseabasicwith2-OMe,Y34) |
1,4,7,10,12,14,17(sense),12(As)*10(As) |
.0037 ± .00013 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0309 |
GCUGCUGCUGY34UGCUGCUG:CGACGACGACUACGACGAC |
2'-Ome*Abasicsite(2R,3S,4S)-2-hydroxy-methyl-4-methoxytetrahydrofuaran-3-ol(pentafuranoseabasicwith2-OMe,Y34) |
1,4,7,10,12,14,17(sense),12(As)*9(As) |
.0025 ± .0005 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0310 |
GCUGCUGCY33GCUGCUGCUG:CGACGACGACGACGACGAC |
2'-Ome*(2R,3S)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol(hexapyranoseabasicmoiety,Y33) |
1,4,7,10,12,14,17(sense),12(As)*11(As) |
.0028 ± .0004 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0311 |
GCUGCUGCUY33CUGCUGCUG:CGACGACGAUGACGACGAC |
2'-Ome*(2R,3S)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol(hexapyranoseabasicmoiety,Y33) |
1,4,7,10,12,14,17(sense),12(As)*10(As) |
.0058 ± .004 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0312 |
GCUGCUGCUGY33UGCUGCUG:CGACGACGACUACGACGAC |
2'-Ome*(2R,3S)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol(hexapyranoseabasicmoiety,Y33) |
1,4,7,10,12,14,17(sense),12(As)*9(As) |
.0033 ± .0006 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0313 |
GCUGCUGCY16Y16CUGCUGCUG:TCGACGACGAAGACGACGAC |
2'-Ome*(2R,3S)-2-(hydroxymethyl)tetrahydrofuran-3-ol(pentafuranoseabasicwith2-deoxy,Y16) |
12*11,12 |
.0061 ± .0014 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0314 |
GCUGCUGCY16Y16Y16UGCUGCUG:CGACGACGAAAACGACGAC |
2'-Ome*(2R,3S)-2-(hydroxymethyl)tetrahydrofuran-3-ol(pentafuranoseabasicwith2-deoxy,Y16) |
12*9,10,11 |
.029 ± .085 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0315 |
GCUGCUGCY16Y16Y16Y16GCUGCUG:CGACGACGAAAACGACGAC |
2'-Ome*(2R,3S)-2-(hydroxymethyl)tetrahydrofuran-3-ol(pentafuranoseabasicwith2-deoxy,Y16) |
12*8,9,10,11 |
.049 ± .065 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0316 |
GCUGCUGCY33Y33CUGCUGCUG:CGACGACGAAGACGACGAC |
2'-Ome*(2R,3S)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol(hexapyranoseabasicmoiety,Y33) |
12*10,11 |
.0034 ± .001 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0317 |
GCUGCUGCY33Y33Y33UGCUGCUG:TCGACGACGAAAACGACGAC |
2'-Ome*(2R,3S)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol(hexapyranoseabasicmoiety,Y33) |
12*10,11 |
.015 ± .042 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0318 |
GCUGCUGCY33Y33Y33Y33GCUGCUG:TCGACGACGAAAACGACGAC |
2'-Ome*(2R,3S)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol(hexapyranoseabasicmoiety,Y33) |
12*8,9,10,11 |
.034 ± .011 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0319 |
GCUGCUGY33Y33GY33UGCUGCUG:CGACGACAACAACGACGAC |
(2R,3S)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol(hexapyranoseabasicmoiety,Y33) |
9,11,12 |
.043 ± .074 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0320 |
GCUGCUGY33Y33Y33Y33UGCUGCUG:CGACGACAAAAACGACGAC |
(2R,3S)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol(hexapyranoseabasicmoiety,Y33) |
9,10,11,12 |
>1 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0321 |
GCUGCUGCUGY33UGCUY33CUG:CGACGACGACAACGAAGAC |
(2R,3S)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol(hexapyranoseabasicmoiety,Y33) |
4,9 |
.047 ± .015 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0322 |
UGCUGCUY33Y33UY33CUGCUGCUGCU:ACGACGAAAAAGACGACGACGA |
2'-Ome*(2R,3S)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol(hexapyranoseabasicmoiety,Y33) |
13,16*12,14,15 |
.0052 ± .0022 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0323 |
UGCUGCUY33Y33Y33GCUGCUGCUGCU:ACGACGAAAACGACGACGACGA |
2'-Ome*(2R,3S)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol(hexapyranoseabasicmoiety,Y33) |
16*13,14,15 |
.0038 ± .0014 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0324 |
UGCUGCUY16Y16UY16CUGCUGCUGCU:ACGACGAAAAAGACGACGACGA |
2'-Ome*(2R,3S)-2-(hydroxymethyl)tetrahydrofuran-3-ol(pentafuranoseabasicwith2-deoxy,Y16) |
13,16*12,14,15 |
.020 ± .0024 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0325 |
UGCUGCUY16Y16Y16GCUGCUGCUGCU:ACGACGAAAACGACGACGACGA |
2'-Ome*(2R,3S)-2-(hydroxymethyl)tetrahydrofuran-3-ol(pentafuranoseabasicwith2-deoxy,Y16) |
16*13,14,15 |
.011 ± .0015 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0326 |
GCUGCUGCAGCUGCUGCUG:CGACGACGUCGACGACGAC |
2'-OMe |
12(sense),1,4,7,10,13,16,19(As) |
0.0028 ± 0.0002 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0327 |
GCUGCUGCAACUGCUGCUG:CGACGACGUUGACGACGAC |
2'-OMe |
12(sense),1,4,7,9,10,13,16,19(As) |
0.0028 ± 0.0003 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0328 |
GCUGCUGCAGCUGCUGCUG:CGACGACGACGACGACGAC |
2'-OMe |
12(sense),1,4,7,10,13,16,19(As) |
0.0033 ± 0.0003 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0329 |
GCUGCUGCUACUGCUGCUG:CGACGACGACGACGACGAC |
2'-OMe |
11(sense),1,4,7,10,13,16,19(As) |
0.0068 ± 0.0007 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0330 |
GCUGCUGCUGAUGCUGCUG:CGACGACGACGACGACGAC |
2'-OMe |
1,4,7,10,13,16,19(As) |
0.0049 ± 0.0006 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0331 |
CUGCUGCUGAUGCUGCUGC:GACGACGACGACGACGACG |
2'-OMe |
3,6,9,12,15,18(As) |
0.0071± 0.0001 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0332 |
UGCUGCUGCAGCUGCUGCU:UGCUGCUGCAGCUGCUGCU |
2'-OMe |
11(sense),9(As) |
0.0051± 0.0001 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0333 |
GCUGCUGAUACUGCUGCUG:CGACGACUAUGACGACGAC |
2'-OMe |
11(sense),4,7,8,10,16,19(As) |
ND |
ND |
ND |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0334 |
GCUGCUGAUGAUGCUGCUG:CGACGACUACUACGACGAC |
2'-OMe |
4,7,8,10,11,16,19 |
ND |
ND |
ND |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0335 |
GCUGCUGAAACUGCUGCUG:CGACGACUUUGACGACGAC |
2'-OMe |
4,7,8,9,10,16,19 |
0.0051± 0.0006 |
.084±0.001 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0336 |
GCUGCUGAAGAUGCUGCUG:CGACGACUUCUACGACGAC |
2'-OMe |
4,7,8,9,10,11,16,19 |
0.0033± 0.0007 |
.067±0.0012 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0337 |
GCUGCUGCAAAUGCUGCUG:CGACGACGUUUACGACGAC |
2'-OMe |
12(sense),4,7,9,10,11,16,19(As) |
0.0014± 0.0005 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0338 |
GCUGCUGAAAAUGCUGCUG:CGACGACUUUUACGACGAC |
2'-OMe |
4,7,8,10,11,16,19 |
0.0036± 0.00013 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0339 |
CUGCUGCAAAUGCUGCUGC:GACGACGUUUACGACGACG |
2'-OMe |
13(sense),3,6,8,9,10,12,15,18(As) |
0.020± 0.0027 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0340 |
CUGCUGCAACAGCUGCUGC:GACGACGUUGUCGACGACG |
2'-OMe |
10(sense),3,6,8,9,10,11,12,15,18(As) |
ND |
ND |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0341 |
CUGCUGCUAAAGCUGCUGC:GACGACGAUUUCGACGACG |
2'-OMe |
12(sense),3,6,9,10,11,12,15,18(As) |
ND |
ND |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0342 |
CUGCUGCAAAAGCUGCUGC:GACGACGUUUUCGACGACG |
2'-OMe |
13(sense),3,6,8,9,10,11,12,15,18(As) |
0.019± 0.0042 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0343 |
UGCUGCUAAUGCUGCUGCU:ACGACGAUUACGACGACGA |
2'-OMe |
13(sense),5,8,9,10,11,17(As) |
ND |
ND |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0344 |
UGCUGCUGAUACUGCUGCU:ACGACGACUAUGACGACGA |
2'-OMe |
10(sense),5,8,9,11,17(As) |
ND |
ND |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0345 |
UGCUGCUAAAGCUGCUGCU:ACGACGAUUUCGACGACGA |
2'-OMe |
13(sense),5,8,9,10,11,17(As) |
0.0028± 0.005 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0346 |
UGCUGCUAAUACUGCUGCU:ACGACGAUUAUGACGACGA |
2'-OMe |
10,14(sense),5,8,9,11,17 |
0.0086± 0.0041 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0347 |
UGCUGCUGAAACUGCUGCU:UGCUGCUGAAACUGCUGCU |
2'-OMe |
1,3,6(As) |
0.0027± 0.0011 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23887934 |
ASP cm-sirna_0348 |
UGCUGCUAAAACUGCUGCU:ACGACGAUUUUGACGACGA |
2'-OMe |
13(sense),5,8,9,10,11,17(As) |
0.0079± 0.0032 |
>1 |
µM |
GM04281 |
RT-PCR |
HTT |
|
23935115 |
ASP cm-sirna_0349 |
TCUGCUGCAGCUGCUGCUGAA |
5'VP*s:Phosphorothioate(PS-linkage)*2′-Ome*2'-F*,2'-MOE |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*3,5,79,11,13,15,17,19*2,4,6,810,12,14,16,18*1,20,21 |
0.0003± 0.0014 |
0.002± 0.0032 |
µM |
Fibroblast |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0350 |
TCUGCUGCAGCUGCUGCUGAA |
5'VP*Phosphorthioate(PS)linkage*2′-Ome*2'-F*,2'-MOE |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*3,5,79,11,13,15,17,19*2,4,6,810,12,14,16,18*1,20,21 |
0.0006± 0.0014 |
0.04± 0.0032 |
µM |
GM04281 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0351 |
TCUGCUGCAGCUGCUGCUGAA |
5'VP*Phosphorthioate(PS)linkage*2′-Ome*2'-F*,2'-MOE |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*3,5,79,11,13,15,17,19*2,4,6,810,12,14,16,18*1,20,21 |
0.0002± 0.0014 |
0.06± 0.0032 |
µM |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0352 |
TCUGCUGCAGCUGCUGCUGAA |
5'VP*Phosphorthioate(PS)linkage*2′-Ome*2'-F*,2'-MOE |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*3,5,79,11,13,15,17,19*2,4,6,810,12,14,16,18*1,20,21 |
0.0002± 0.0014 |
0.08± 0.0032 |
µM |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0353 |
TCUACUGCUGCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0354 |
TCUGAUGCUGCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0355 |
TCUGCAGCUGCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Moderate efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0356 |
TCUGCUACUGCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0357 |
TCUGCUGAUGCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0358 |
TCUGCUGCAGCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Highest efficacy |
Lowest efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0359 |
TCUGCUGCUACUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Moderate efficacy |
Lowest efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0360 |
TCUGCUGCUUCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Low efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0361 |
TCUGCUGCUGAUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Lowest efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0362 |
TCUGCUGCUGCAGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Moderate efficacy |
Lowest efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0363 |
TCUGCUGCUGCUACUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0364 |
TCUGCUGCUGCUGCUACUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Highest efficacy |
Lowest efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0365 |
TCUGCUGCAACUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0366 |
TCUGCUGCAAAUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0367 |
TCUGCUGAAAAUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Moderate efficacy |
Lowest efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0368 |
TCUACUGCUACUGCUACUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Low efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0369 |
TCAGCUGUUGCUACUGUUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
Lowest efficacy |
Lowest efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0370 |
TGCUGCUGCUGCUGCUGCUAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
Lowest efficacy |
Lowest efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0371 |
TCUGCUGCAGCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Highest efficacy |
Lowest efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0372 |
TCUGCUGCAGCUGCUGCUAA |
2'-MOE*2'-F*2'-Ome |
1,19,20*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17 |
High efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0373 |
TCUGCUGCAGCUGCUGCAA |
2'-MOE*2'-F*2'-Ome |
1,18,19*2,4,6,8,10,12,14,16*3,5,7,9,11,13,15,17 |
Moderate efficacy |
Lowest efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0374 |
TCUGCUGCAGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,17,18*2,4,6,8,10,12,14,16*3,5,7,9,11,13,15 |
Moderate efficacy |
Lowest efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0375 |
TCUGCUGCAGCUGCUAA |
2'-MOE*2'-F*2'-Ome |
1,16,17*2,4,6,8,10,12,14,*3,5,7,9,11,13,15 |
Low efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0376 |
TCUGCUGCAGCUGCAA |
2'-MOE*2'-F*2'-Ome |
1,15,16*2,4,6,8,10,12,14,*3,5,7,9,11,13 |
Low efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0377 |
TCUGCUGCAGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,14,15*2,4,6,8,10,12,*3,5,7,9,11,13 |
Lowest efficacy |
Lowest efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0378 |
TCUGCUGCAGAUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0379 |
TCUGCUGCAGCAGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
Moderate efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0380 |
TCUGCUGCAGCUACUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0381 |
TCUGCUGCAGCUGAUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0382 |
TCUGCUGCAGCUGCAGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
Low efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0383 |
TCUGCUGCAGCUGCUCCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0384 |
TCUGCUGCAGCUGCUGAUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0385 |
TCUGCUGCAGCUGCUGCAGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
Low efficacy |
Low efficacy |
% |
GM06151 |
Western blot |
ATXN3 |
|
23935115 |
ASP cm-sirna_0386 |
TCUGCUGCAGCUGCUGCUGAA |
5'VP*s:Phosphorothioate*2'MOE*2'-F*,2′-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*3,5,79,11,13,15,17,19*2,4,6,810,12,14,16,18*1,20,21 |
0.0003± 0.0014 |
0.002± 0.0032 |
µM |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0387 |
TCUGCUGCAGCUGCUGCUGAA |
5'VP*Phosphorthioate(PS)linkage*2'MOE*2'-F*,2′-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*3,5,79,11,13,15,17,19*2,4,6,810,12,14,16,18*1,20,21 |
0.0006± 0.0014 |
0.04± 0.0032 |
µM |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0388 |
TCUGCUGCAGCUGCUGCUGAA |
5'VP*Phosphorthioate(PS)linkage*2'MOE*2'-F*,2′-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*3,5,79,11,13,15,17,19*2,4,6,810,12,14,16,18*1,20,21 |
0.0002± 0.0014 |
0.06± 0.0032 |
µM |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0389 |
TCUGCUGCAGCUGCUGCUGAA |
5'VP*Phosphorthioate(PS)linkage*2'MOE*2'-F*,2′-Ome |
1*1,2,4,6,8,10,12,14,15,16,17,18,19,20*3,5,79,11,13,15,17,19*2,4,6,810,12,14,16,18*1,20,21 |
0.0002± 0.0014 |
0.08± 0.0032 |
µM |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0390 |
TCUACUGCUGCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0391 |
TCUGAUGCUGCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0392 |
TCUGCAGCUGCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Moderate efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0393 |
TCUGCUACUGCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0394 |
TCUGCUGAUGCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0395 |
TCUGCUGCAGCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Highest efficacy |
Lowest efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0396 |
TCUGCUGCUACUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Moderate efficacy |
Lowest efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0397 |
TCUGCUGCUUCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Low efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0398 |
TCUGCUGCUGAUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Lowest efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0399 |
TCUGCUGCUGCAGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Moderate efficacy |
Lowest efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0400 |
TCUGCUGCUGCUACUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0401 |
TCUGCUGCUGCUGCUACUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Highest efficacy |
Lowest efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0402 |
TCUGCUGCAACUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0403 |
TCUGCUGCAAAUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0404 |
TCUGCUGAAAAUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Moderate efficacy |
Lowest efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0405 |
TCUACUGCUACUGCUACUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Low efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0406 |
TCAGCUGUUGCUACUGUUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
Lowest efficacy |
Lowest efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0407 |
TGCUGCUGCUGCUGCUGCUAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
Lowest efficacy |
Lowest efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0408 |
TCUGCUGCAGCUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17,19 |
Highest efficacy |
Lowest efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0409 |
TCUGCUGCAGCUGCUGCUAA |
2'-MOE*2'-F*2'-Ome |
1,19,20*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,15,17 |
High efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0410 |
TCUGCUGCAGCUGCUGCAA |
2'-MOE*2'-F*2'-Ome |
1,18,19*2,4,6,8,10,12,14,16*3,5,7,9,11,13,15,17 |
Moderate efficacy |
Lowest efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0411 |
TCUGCUGCAGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,17,18*2,4,6,8,10,12,14,16*3,5,7,9,11,13,15 |
Moderate efficacy |
Lowest efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0412 |
TCUGCUGCAGCUGCUAA |
2'-MOE*2'-F*2'-Ome |
1,16,17*2,4,6,8,10,12,14,*3,5,7,9,11,13,15 |
Low efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0413 |
TCUGCUGCAGCUGCAA |
2'-MOE*2'-F*2'-Ome |
1,15,16*2,4,6,8,10,12,14,*3,5,7,9,11,13 |
Low efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0414 |
TCUGCUGCAGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,14,15*2,4,6,8,10,12,*3,5,7,9,11,13 |
Lowest efficacy |
Lowest efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0415 |
TCUGCUGCAGAUGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0416 |
TCUGCUGCAGCAGCUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
Moderate efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0417 |
TCUGCUGCAGCUACUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0418 |
TCUGCUGCAGCUGAUGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0419 |
TCUGCUGCAGCUGCAGCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
Low efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0420 |
TCUGCUGCAGCUGCUCCUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0421 |
TCUGCUGCAGCUGCUGAUGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
High efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |
|
23935115 |
ASP cm-sirna_0422 |
TCUGCUGCAGCUGCUGCAGAA |
2'-MOE*2'-F*2'-Ome |
1,20,21*2,4,6,8,10,12,14,16,18*3,5,7,9,11,13,17,19 |
Low efficacy |
Low efficacy |
% |
GM06151 |
RT-PCR |
ATXN3 |