BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 14 [TOP]

Compound ID	1809
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)	Rifampin (0.533 ± 0.08 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (2.7 ± 0.36 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	18182260
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra roots.J Ethnopharmacol. 2008 Mar 5;116(2):377-80
Curator

Record - 2 of 14 [TOP]

Compound ID	1810
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)	Rifampin (0.23 ± 0.06 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (0.116 ± 0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	18182260
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra roots.J Ethnopharmacol. 2008 Mar 5;116(2):377-80
Curator

Record - 3 of 14 [TOP]

Compound ID	1811
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Ethyl acetate fraction
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)	Rifampin (0.533 ± 0.08 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (2.7 ± 0.36 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	116.67 ± 14.43 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	18182260
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra roots.J Ethnopharmacol. 2008 Mar 5;116(2):377-80
Curator

Record - 4 of 14 [TOP]

Compound ID	1812
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Ethyl acetate fraction
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)	Rifampin (0.23 ± 0.06 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (0.116 ± 0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	18182260
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra roots.J Ethnopharmacol. 2008 Mar 5;116(2):377-80
Curator

Record - 5 of 14 [TOP]

Compound ID	1813
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Column fraction
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)	Rifampin (0.533 ± 0.08 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (2.7 ± 0.36 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	58.33 ± 7.21 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	18182260
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra roots.J Ethnopharmacol. 2008 Mar 5;116(2):377-80
Curator

Record - 6 of 14 [TOP]

Compound ID	1814
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Column fraction
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)	Rifampin (0.23 ± 0.06 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (0.116 ± 0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	116.67 ± 14.43 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	18182260
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra roots.J Ethnopharmacol. 2008 Mar 5;116(2):377-80
Curator

Record - 7 of 14 [TOP]

Compound ID

1815

Compound Structure

Plant Source

Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)

Source Family

Fabaceae

Origin

India, Africa

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

BACTEC Assay

Positive Control Used (conc.)

Rifampin (0.23 ± 0.06 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (0.116 ± 0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

29.16 ± 3.61 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Glabridin

PubChem ID

124052

Ethnomedicinal Information

Expectorant, consumption, bronchitis, chest complaint, cough

PubMed ID [Source Literature]

18182260

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzopyran, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C[C@H](Cc2c1c1c(OC(C=C1)(C)C)cc2)c1c(O)cc(O)cc1

XLogP

3.207

PSA

58.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra roots.J Ethnopharmacol. 2008 Mar 5;116(2):377-80

Curator

Record - 8 of 14 [TOP]

Compound ID

2646

Compound Structure

Plant Source

Strobilanthes cusia Common Name:

Source Family

Acanthaceae

Origin

China, Taiwan

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

BACTEC Assay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

1 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Tryptanthrin

PubChem ID

73549

Ethnomedicinal Information

Has folkloric reputation for the topical treatment of athletes foot

PubMed ID [Source Literature]

9828037

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Quinazolinone, Alkaloid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

248.059

Molecular Formula

C₁₅H₈N₂O₂

SMILES

O=C1c2n(c3c1cccc3)c(=O)c1c(n2)cccc1

XLogP

3.519

PSA

46.500

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Mitscher LA, Baker W.Tuberculosis: a search for novel therapy starting with natural products.Med Res Rev. 1998 Nov;18(6):363-74

2) L. A. Mitscher and W. R. Baker.A search for novel chemotherapy against tuberculosis amongst natural products.Pure Appl. Chem., 1998, Vol. 70, No. 2, pp. 365-371

Curator

Record - 9 of 14 [TOP]

Compound ID

2648

Compound Structure

Plant Source

Strobilanthes cusia Common Name:

Source Family

Acanthaceae

Origin

China, Taiwan

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium complex

Assay / Test Done

BACTEC Assay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Tryptanthrin

PubChem ID

73549

Ethnomedicinal Information

Has folkloric reputation for the topical treatment of athletes foot

PubMed ID [Source Literature]

9828037

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Quinazolinone, Alkaloid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

248.059

Molecular Formula

C₁₅H₈N₂O₂

SMILES

O=C1c2n(c3c1cccc3)c(=O)c1c(n2)cccc1

XLogP

3.519

PSA

46.500

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 10 of 14 [TOP]

Compound ID	2838
Compound Structure
Plant Source	Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)
Source Family	Zingiberaceae
Origin	India, Malaysia
Plant Part Used	Rhizome
Extract	Methylene chloride
Target Bacteria
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)
Inhibition [%]	85 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis
PubMed ID [Source Literature]	21094237
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mohamad S, Zin NM, Wahab HA, Ibrahim P, Sulaiman SF, Zahariluddin AS, Noor SS.Antituberculosis potential of some ethnobotanically selected Malaysian plants.J Ethnopharmacol. 2011 Feb 16;133(3):1021-6
Curator

Record - 11 of 14 [TOP]

Compound ID

3971

Compound Structure

Plant Source

Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)

Source Family

Fabaceae

Origin

India, Africa

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

BACTEC Assay

Positive Control Used (conc.)

Rifampin (0.23 ± 0.06 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (0.116 ± 0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

29.16 ± 3.61 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Glabridin

PubChem ID

124052

Ethnomedicinal Information

Expectorant, consumption, bronchitis, chest complaint, cough

PubMed ID [Source Literature]

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzopyran, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C[C@H](Cc2c1c1c(OC(C=C1)(C)C)cc2)c1c(O)cc(O)cc1

XLogP

3.207

PSA

58.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 12 of 14 [TOP]

Compound ID

3412

Compound Structure

Plant Source

Glycyrrhiza inflata Common Name:Chinese Licorice

Source Family

Fabaceae

Origin

India

Plant Part Used

Root

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

BACTEC Assay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

< 20 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licochalcone A

PubChem ID

5318998

Ethnomedicinal Information

PubMed ID [Source Literature]

12058317

Extract Preparation

Soxhlet extraction, concentrated in vacuo to dryness

Chemical Classification [Active Compound]

Aromatic, Alkene, Chalcone, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

338.152

Molecular Formula

C₂₁H₂₂O₄

SMILES

Oc1c(C(C)(C)C=C)cc(c(OC)c1)/C=C/C(=O)c1ccc(O)cc1

XLogP

4.443

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Friis-Møller A, Chen M, Fuursted K, Christensen SB, Kharazmi A.In vitro antimycobacterial and antilegionella activity of licochalcone A from Chinese licorice roots.Planta Med. 2002 May;68(5):416-9

Curator

Gppreetha, vikramjitmandal

Record - 13 of 14 [TOP]

Compound ID

3569

Compound Structure

Plant Source

Haplopappus sonorensis (A. Gray) S.F. Blake Common Name:

Source Family

Asteraceae (Compositae)

Origin

Mexico

Plant Part Used

Whole plant

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 27 294)

Assay / Test Done

BACTEC Assay

Positive Control Used (conc.)

Rifampin

Inhibition [%]

98 %

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Ermanin

PubChem ID

5352001

Ethnomedicinal Information

Antiviral, anti-inflammatory

PubMed ID [Source Literature]

12727485

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Against HCT - 116 (ATCC CCL - 247)

Molecular Weight

314.079

Molecular Formula

C₁₇H₁₄O₆

SMILES

O1c(c(OC)c(=O)c2c1cc(O)cc2O)c1ccc(OC)cc1

XLogP

2.045

PSA

75.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Murillo JI, Encarnación-Dimayuga R, Malmstrøm J, Christophersen C, Franzblau SG.Antimycobacterial flavones from Haplopappus sonorensis.Fitoterapia. 2003 Apr;74(3):226-30

Curator

Gppreetha, vikramjitmandal

Record - 14 of 14 [TOP]

Compound ID	3570
Compound Structure
Plant Source	Haplopappus sonorensis (A. Gray) S.F. Blake Common Name:
Source Family	Asteraceae (Compositae)
Origin	Mexico
Plant Part Used	Whole plant
Extract	Light petroleum, dichloromethane
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)	Rifampin
Inhibition [%]	60 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiviral, anti-inflammatory
PubMed ID [Source Literature]	12727485
Extract Preparation	Soxhlet extraction, concentrated in vacuo to dryness
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]	Against HCT - 116 (ATCC CCL - 247)
Reference(s)	1) Murillo JI, Encarnación-Dimayuga R, Malmstrøm J, Christophersen C, Franzblau SG.Antimycobacterial flavones from Haplopappus sonorensis.Fitoterapia. 2003 Apr;74(3):226-30
Curator	Gppreetha, vikramjitmandal

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