BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 18 [TOP]

Compound ID	2856
Compound Structure	N/A
Plant Source	Lippia origanoides Common Name:Wild Marjoram
Source Family	Verbenaceae
Origin	Colombia
Plant Part Used	Leaf, stem
Extract	Leaf and stem (3.1 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	MTT assay
Positive Control Used (conc.)	Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	125 ± 0.01 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Mixture of Essential oils (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19753839
Extract Preparation	Microwave - Assisted Hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven (Kendo, MO-124, 2.5 GHz, 800 W) (9). Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60
Curator	Keya Mukherjee, reshmi

Record - 2 of 18 [TOP]

Compound ID	2857
Compound Structure	N/A
Plant Source	Lippia origanoides Common Name:Wild Marjoram
Source Family	Verbenaceae
Origin	Colombia
Plant Part Used	Leaf, stem
Extract	Leaf and stem (3.1 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	MTT assay
Positive Control Used (conc.)	Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	125 ± 0.01 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Mixture of Essential oils (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19753839
Extract Preparation	Microwave - Assisted Hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven (Kendo, MO-124, 2.5 GHz, 800 W) (9). Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60
Curator	Keya Mukherjee, reshmi

Record - 3 of 18 [TOP]

Compound ID

3563

Compound Structure

Plant Source

Cryptolepis sanguinolenta Common Name:Nibima

Source Family

Apocynaceae

Origin

West Africa

Plant Part Used

Root

Extract

Ammonia moistened chloroform

Target Bacteria

Mycobacterium fortuitum

Assay / Test Done

MTT Assay

Positive Control Used (conc.)

Ethambutol (8 µg/ml), Isoniazid (0.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

16 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cryptolepine hydrochloride

PubChem ID

156093

Ethnomedicinal Information

Antimycobacterial, antimalarial

PubMed ID [Source Literature]

12722159

Extract Preparation

Cryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Indole

Media / Broth Used [Antimicrobial Assay/Test]

Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium

Cytotoxicity Assay [AID]

Molecular Weight

232.100

Molecular Formula

C₁₆H₁₃ClN₂

SMILES

Cl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C

XLogP

4.596

PSA

15.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

Curator

Wvarsha, rachanake

Record - 4 of 18 [TOP]

Compound ID

3564

Compound Structure

Plant Source

Cryptolepis sanguinolenta Common Name:Nibima

Source Family

Apocynaceae

Origin

West Africa

Plant Part Used

Root

Extract

Ammonia moistened chloroform

Target Bacteria

Mycobacterium smegmatis (ATCC 14468)

Assay / Test Done

MTT Assay

Positive Control Used (conc.)

Ethambutol (0.25 µg/ml), Isoniazid (2 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cryptolepine hydrochloride

PubChem ID

156093

Ethnomedicinal Information

Antimycobacterial, antimalarial

PubMed ID [Source Literature]

12722159

Extract Preparation

Cryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Indole

Media / Broth Used [Antimicrobial Assay/Test]

Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium

Cytotoxicity Assay [AID]

Molecular Weight

232.100

Molecular Formula

C₁₆H₁₃ClN₂

SMILES

Cl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C

XLogP

4.596

PSA

15.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

Curator

Wvarsha, rachanake

Record - 5 of 18 [TOP]

Compound ID

3565

Compound Structure

Plant Source

Cryptolepis sanguinolenta Common Name:Nibima

Source Family

Apocynaceae

Origin

West Africa

Plant Part Used

Root

Extract

Ammonia moistened chloroform

Target Bacteria

Mycobacterium phlei

Assay / Test Done

MTT Assay

Positive Control Used (conc.)

Ethambutol (1 µg/ml), Isoniazid (2 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cryptolepine hydrochloride

PubChem ID

156093

Ethnomedicinal Information

Antimycobacterial, antimalarial

PubMed ID [Source Literature]

12722159

Extract Preparation

Cryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Indole

Media / Broth Used [Antimicrobial Assay/Test]

Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium

Cytotoxicity Assay [AID]

Molecular Weight

232.100

Molecular Formula

C₁₆H₁₃ClN₂

SMILES

Cl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C

XLogP

4.596

PSA

15.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

Curator

Wvarsha, rachanake

Record - 6 of 18 [TOP]

Compound ID

3566

Compound Structure

Plant Source

Cryptolepis sanguinolenta Common Name:Nibima

Source Family

Apocynaceae

Origin

West Africa

Plant Part Used

Root

Extract

Ammonia moistened chloroform

Target Bacteria

Mycobacterium abscessus

Assay / Test Done

MTT Assay

Positive Control Used (conc.)

Ethambutol (128 µg/ml), Isoniazid (32 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

32 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cryptolepine hydrochloride

PubChem ID

156093

Ethnomedicinal Information

Antimycobacterial, antimalarial

PubMed ID [Source Literature]

12722159

Extract Preparation

Cryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Indole

Media / Broth Used [Antimicrobial Assay/Test]

Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium

Cytotoxicity Assay [AID]

Molecular Weight

232.100

Molecular Formula

C₁₆H₁₃ClN₂

SMILES

Cl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C

XLogP

4.596

PSA

15.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

Curator

Wvarsha, rachanake

Record - 7 of 18 [TOP]

Compound ID

3567

Compound Structure

Plant Source

Cryptolepis sanguinolenta Common Name:Nibima

Source Family

Apocynaceae

Origin

West Africa

Plant Part Used

Root

Extract

Ammonia moistened chloroform

Target Bacteria

Mycobacterium aurum

Assay / Test Done

MTT Assay

Positive Control Used (conc.)

Ethambutol (1 µg/ml), Isoniazid (2 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cryptolepine hydrochloride

PubChem ID

156093

Ethnomedicinal Information

Antimycobacterial,AntimalAerial

PubMed ID [Source Literature]

12722159

Extract Preparation

Cryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Indole

Media / Broth Used [Antimicrobial Assay/Test]

Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium

Cytotoxicity Assay [AID]

Molecular Weight

232.100

Molecular Formula

C₁₆H₁₃ClN₂

SMILES

Cl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C

XLogP

4.596

PSA

15.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

Curator

Wvarsha, rachanake

Record - 8 of 18 [TOP]

Compound ID

3568

Compound Structure

Plant Source

Cryptolepis sanguinolenta Common Name:Nibima

Source Family

Apocynaceae

Origin

West Africa

Plant Part Used

Root

Extract

Ammonia moistened chloroform

Target Bacteria

Mycobacterium bovis (BCG - Bacillus Calmette Guerin)

Assay / Test Done

MTT Assay

Positive Control Used (conc.)

Streptomycin sulphate (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cryptolepine hydrochloride

PubChem ID

156093

Ethnomedicinal Information

Antimycobacterial,AntimalAerial

PubMed ID [Source Literature]

12722159

Extract Preparation

Cryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Indole

Media / Broth Used [Antimicrobial Assay/Test]

Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium

Cytotoxicity Assay [AID]

Molecular Weight

232.100

Molecular Formula

C₁₆H₁₃ClN₂

SMILES

Cl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C

XLogP

4.596

PSA

15.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

Curator

Wvarsha, rachanake

Record - 9 of 18 [TOP]

Compound ID	3778
Compound Structure	NR
Plant Source	Evodia elleryana (Melicope elleryana) Common Name:Sehit
Source Family	Rutaceae
Origin	Kurti region of Manus Island, Papua New Guinea
Plant Part Used	Bark
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis H37Ra (ATCC 25177)
Assay / Test Done	MTT assay
Positive Control Used (conc.)	Rifampin (5 µg/ml), Isoniazid (50 µg/ml)
Inhibition [%]	>= 70 % (50 µg/ml)
Activity [MIC] µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Cough, fever, whooping cough, occasionally used to control fertility in women
PubMed ID [Source Literature]	17350179
Extract Preparation	Soxhlet extracts (hexane, ethyl acetate and methanol in sequence) of bark, stem and leaves
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]	Against Human T cells
Reference(s)	1) Barrows LR, Powan E, Pond CD, Matainaho T.Anti-TB activity of Evodia elleryana bark extract.Fitoterapia. 2007 Apr;78(3):250-2. Epub 2007 Feb 3
Curator	Vikramjitmandal, rachanake

Record - 10 of 18 [TOP]

Compound ID	3780
Compound Structure	NR
Plant Source	Evodia elleryana (Melicope elleryana) Common Name:Sehit
Source Family	Rutaceae
Origin	Kurti region of Manus Island, Papua New Guinea
Plant Part Used	Bark
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Ra (ATCC 25177)
Assay / Test Done	MTT assay
Positive Control Used (conc.)	Rifampin (5 µg/ml), Isoniazid (50 µg/ml)
Inhibition [%]	< 30 % (50 µg/ml)
Activity [MIC] µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Cough, fever, whooping cough, occasionally used to control fertility in women
PubMed ID [Source Literature]	17350179
Extract Preparation	Soxhlet extracts (hexane, ethyl acetate and methanol in sequence) of bark, stem and leaves
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]	Against Human T cells
Reference(s)	1) Barrows LR, Powan E, Pond CD, Matainaho T.Anti-TB activity of Evodia elleryana bark extract.Fitoterapia. 2007 Apr;78(3):250-2. Epub 2007 Feb 3
Curator	Vikramjitmandal, rachanake

Record - 11 of 18 [TOP]

Compound ID	3782
Compound Structure	NR
Plant Source	Evodia elleryana (Melicope elleryana) Common Name:Sehit
Source Family	Rutaceae
Origin	Kurti region of Manus Island, Papua New Guinea
Plant Part Used	Bark
Extract	Ethyl acetate
Target Bacteria	Mycobacterium tuberculosis H37Ra (ATCC 25177)
Assay / Test Done	MTT assay
Positive Control Used (conc.)	Rifampin (5 µg/ml), Isoniazid (50 µg/ml)
Inhibition [%]	>= 70 % (50 µg/ml)
Activity [MIC] µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Cough, fever, whooping cough, occasionally used to control fertility in women
PubMed ID [Source Literature]	17350179
Extract Preparation	Soxhlet extracts (hexane, ethyl acetate and methanol in sequence) of bark, stem and leaves
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]	Against Human T cells
Reference(s)	1) Barrows LR, Powan E, Pond CD, Matainaho T.Anti-TB activity of Evodia elleryana bark extract.Fitoterapia. 2007 Apr;78(3):250-2. Epub 2007 Feb 3
Curator	Vikramjitmandal, rachanake

Record - 12 of 18 [TOP]

Compound ID	3784
Compound Structure	NR
Plant Source	Evodia elleryana (Melicope elleryana) Common Name:Sehit
Source Family	Rutaceae
Origin	Kurti region of Manus Island, Papua New Guinea
Plant Part Used	Stem
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis H37Ra (ATCC 25177)
Assay / Test Done	MTT assay
Positive Control Used (conc.)	Rifampin (5 µg/ml), Isoniazid (50 µg/ml)
Inhibition [%]	< 70 % and >= 30 % (50 µg/ml)
Activity [MIC] µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Cough, fever, whooping cough, occasionally used to control fertility in women
PubMed ID [Source Literature]	17350179
Extract Preparation	Soxhlet extracts (hexane, ethyl acetate and methanol in sequence) of bark, stem and leaves
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]	Against Human T cells
Reference(s)	1) Barrows LR, Powan E, Pond CD, Matainaho T.Anti-TB activity of Evodia elleryana bark extract.Fitoterapia. 2007 Apr;78(3):250-2. Epub 2007 Feb 3
Curator	Vikramjitmandal, rachanake

Record - 13 of 18 [TOP]

Compound ID	3786
Compound Structure	NR
Plant Source	Evodia elleryana (Melicope elleryana) Common Name:Sehit
Source Family	Rutaceae
Origin	Kurti region of Manus Island, Papua New Guinea
Plant Part Used	Stem
Extract	Ethyl acetate
Target Bacteria	Mycobacterium tuberculosis H37Ra (ATCC 25177)
Assay / Test Done	MTT assay
Positive Control Used (conc.)	Rifampin (5 µg/ml), Isoniazid (50 µg/ml)
Inhibition [%]	< 30 % (50 µg/ml)
Activity [MIC] µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Cough, fever, whooping cough, occasionally used to control fertility in women
PubMed ID [Source Literature]	17350179
Extract Preparation	Soxhlet extracts (hexane, ethyl acetate and methanol in sequence) of bark, stem and leaves
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]	Against Human T cells
Reference(s)	1) Barrows LR, Powan E, Pond CD, Matainaho T.Anti-TB activity of Evodia elleryana bark extract.Fitoterapia. 2007 Apr;78(3):250-2. Epub 2007 Feb 3
Curator	Vikramjitmandal, rachanake

Record - 14 of 18 [TOP]

Compound ID	3788
Compound Structure	NR
Plant Source	Evodia elleryana (Melicope elleryana) Common Name:Sehit
Source Family	Rutaceae
Origin	Kurti region of Manus Island, Papua New Guinea
Plant Part Used	Stem
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Ra (ATCC 25177)
Assay / Test Done	MTT assay
Positive Control Used (conc.)	Rifampin (5 µg/ml), Isoniazid (50 µg/ml)
Inhibition [%]	< 30 % (50 µg/ml)
Activity [MIC] µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Cough, fever, whooping cough, occasionally used to control fertility in women
PubMed ID [Source Literature]	17350179
Extract Preparation	Soxhlet extracts (hexane, ethyl acetate and methanol in sequence) of bark, stem and leaves
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]	Against Human T cells
Reference(s)	1) Barrows LR, Powan E, Pond CD, Matainaho T.Anti-TB activity of Evodia elleryana bark extract.Fitoterapia. 2007 Apr;78(3):250-2. Epub 2007 Feb 3
Curator	Vikramjitmandal, rachanake

Record - 15 of 18 [TOP]

Compound ID	3790
Compound Structure	NR
Plant Source	Evodia elleryana (Melicope elleryana) Common Name:Sehit
Source Family	Rutaceae
Origin	Kurti region of Manus Island, Papua New Guinea
Plant Part Used	Leaf
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis H37Ra (ATCC 25177)
Assay / Test Done	MTT assay
Positive Control Used (conc.)	Rifampin (5 µg/ml), Isoniazid (50 µg/ml)
Inhibition [%]	< 70 % and >= 30 % (50 µg/ml)
Activity [MIC] µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Cough, fever, whooping cough, occasionally used to control fertility in women
PubMed ID [Source Literature]	17350179
Extract Preparation	Soxhlet extracts (hexane, ethyl acetate and methanol in sequence) of bark, stem and leaves
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]	Against Human T cells
Reference(s)	1) Barrows LR, Powan E, Pond CD, Matainaho T.Anti-TB activity of Evodia elleryana bark extract.Fitoterapia. 2007 Apr;78(3):250-2. Epub 2007 Feb 3
Curator	Vikramjitmandal, rachanake

Record - 16 of 18 [TOP]

Compound ID	3792
Compound Structure	NR
Plant Source	Evodia elleryana (Melicope elleryana) Common Name:Sehit
Source Family	Rutaceae
Origin	Kurti region of Manus Island, Papua New Guinea
Plant Part Used	Leaf
Extract	Ethyl acetate
Target Bacteria	Mycobacterium tuberculosis H37Ra (ATCC 25177)
Assay / Test Done	MTT assay
Positive Control Used (conc.)	Rifampin (5 µg/ml), Isoniazid (50 µg/ml)
Inhibition [%]	< 30 % (50 µg/ml)
Activity [MIC] µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Cough, fever, whooping cough, occasionally used to control fertility in women
PubMed ID [Source Literature]	17350179
Extract Preparation	Soxhlet extracts (hexane, ethyl acetate and methanol in sequence) of bark, stem and leaves
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]	Against Human T cells
Reference(s)	1) Barrows LR, Powan E, Pond CD, Matainaho T.Anti-TB activity of Evodia elleryana bark extract.Fitoterapia. 2007 Apr;78(3):250-2. Epub 2007 Feb 3
Curator	Vikramjitmandal, rachanake

Record - 17 of 18 [TOP]

Compound ID	3794
Compound Structure	NR
Plant Source	Evodia elleryana (Melicope elleryana) Common Name:Sehit
Source Family	Rutaceae
Origin	Kurti region of Manus Island, Papua New Guinea
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Ra (ATCC 25177)
Assay / Test Done	MTT assay
Positive Control Used (conc.)	Rifampin (5 µg/ml), Isoniazid (50 µg/ml)
Inhibition [%]	< 30 % (50 µg/ml)
Activity [MIC] µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Cough, fever, whooping cough, occasionally used to control fertility in women
PubMed ID [Source Literature]	17350179
Extract Preparation	Soxhlet extracts (hexane, ethyl acetate and methanol in sequence) of bark, stem and leaves
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]	Against Human T cells
Reference(s)	1) Barrows LR, Powan E, Pond CD, Matainaho T.Anti-TB activity of Evodia elleryana bark extract.Fitoterapia. 2007 Apr;78(3):250-2. Epub 2007 Feb 3
Curator	Vikramjitmandal, rachanake

Record - 18 of 18 [TOP]

Compound ID

3861

Compound Structure

Plant Source

Rhus taitensis Guill. Common Name:Pumac

Source Family

Anacardiaceae

Origin

Papua New Guinea

Plant Part Used

Leaf, twig

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra (ATCC 25177)

Assay / Test Done

MTT Assay

Positive Control Used (conc.)

Rifampin (0.0025 - 0.0079 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

10 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Tetrahydroxysqualene

PubChem ID

25058109

Ethnomedicinal Information

PubMed ID [Source Literature]

18710283

Extract Preparation

Air - dried leaves and twigs (108.6 g) of Rhus taitensis were ground and extracted with 250 ml MeOH (3 × 24 hours) at room temperature. The crude extract (1.7 g) was filtered and concentrated in vacuo. 5 grams of the crude extract were dissolved in MeOH and mixed with 5 g of HP20SS and dried. The mixture was then poured into a column and fractionated using 100 % water, 75 % H₂O / 25 % 2 - propanol, 50 % H₂O / 50 % 2 - propanol, 25 % H₂O / 75 % 2 - propanol, and 100 % MeOH to yield five fractions designated FW, F1, F2, F3, F4, respectively. The fractions were collected and the solvents evaporated using a centrifugal evaporator

Chemical Classification [Active Compound]

Aliphatic, Alkene, Terpene, Triterpene, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

ADC (Remel) supplemented 7H9 medium

Cytotoxicity Assay [AID]

Against Human T cells

Molecular Weight

474.371

Molecular Formula

C₃₀H₅₀O₄

SMILES

OCC(=CCC/C(=C/CC/C(=C/CC/C=C(/CC/C=C(/CCC=C(CO)CO)C)C)/C)/C)CO

XLogP

5.646

PSA

80.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Noro JC, Barrows LR, Gideon OG, Ireland CM, Koch M, Matainaho T, Piskaut P, Pond CD, Bugni TS.Tetrahdroxysqualene from Rhus taitensis shows antimycobacterial activity against Mycobacterium tuberculosis.J Nat Prod. 2008 Sep;71(9):1623-4. Epub 2008 Aug 19

Curator

KeyaMukherjee, Farzana Shamsudeen, gppreetha

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