BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 11 [TOP]

Compound ID	1210
Compound Structure
Plant Source	Artemisia afra Jacq. ex Willd. Common Name:Wild Wormwood
Source Family	Asteraceae (Compositae)
Origin	Africa
Plant Part Used	Leaf
Extract	Ethanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Radiometric assay using BACTEC 460 system
Positive Control Used (conc.)	Ciprofloxacin (0.156 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1563 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Coughs, colds, fever, loss of appetite, chest pains
PubMed ID [Source Literature]	18412151
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mativandlela SP, Meyer JJ, Hussein AA, Houghton PJ, Hamilton CJ, Lall N.Activity against Mycobacterium smegmatis and M. tuberculosis by extract of South African medicinal plants.Phytother Res. 2008 Jun;22(6):841-5
Curator

Record - 2 of 11 [TOP]

Compound ID	1211
Compound Structure
Plant Source	Artemisia afra Jacq. ex Willd. Common Name:Wild Wormwood
Source Family	Asteraceae (Compositae)
Origin	Africa
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Radiometric assay using BACTEC 460 system
Positive Control Used (conc.)	Ciprofloxacin (0.156 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1563 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Coughs, colds, fever, loss of appetite, chest pains
PubMed ID [Source Literature]	18412151
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mativandlela SP, Meyer JJ, Hussein AA, Houghton PJ, Hamilton CJ, Lall N.Activity against Mycobacterium smegmatis and M. tuberculosis by extract of South African medicinal plants.Phytother Res. 2008 Jun;22(6):841-5
Curator

Record - 3 of 11 [TOP]

Compound ID	1212
Compound Structure
Plant Source	Artemisia afra Jacq. ex Willd. Common Name:Wild Wormwood
Source Family	Asteraceae (Compositae)
Origin	Africa
Plant Part Used	Leaf
Extract	Ethanol
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Radiometric assay using BACTEC 460 system
Positive Control Used (conc.)	Ciprofloxacin (0.156 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	3125 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Coughs, colds, fever, loss of appetite, chest pains
PubMed ID [Source Literature]	18412151
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mativandlela SP, Meyer JJ, Hussein AA, Houghton PJ, Hamilton CJ, Lall N.Activity against Mycobacterium smegmatis and M. tuberculosis by extract of South African medicinal plants.Phytother Res. 2008 Jun;22(6):841-5
Curator

Record - 4 of 11 [TOP]

Compound ID	1213
Compound Structure
Plant Source	Artemisia afra Jacq. ex Willd. Common Name:Wild Wormwood
Source Family	Asteraceae (Compositae)
Origin	Africa
Plant Part Used	Leaf
Extract	Dichloromethane
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Radiometric assay using BACTEC 460 system
Positive Control Used (conc.)	Ciprofloxacin (0.156 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	3125 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Coughs, colds, fever, loss of appetite, chest pains
PubMed ID [Source Literature]	18412151
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mativandlela SP, Meyer JJ, Hussein AA, Houghton PJ, Hamilton CJ, Lall N.Activity against Mycobacterium smegmatis and M. tuberculosis by extract of South African medicinal plants.Phytother Res. 2008 Jun;22(6):841-5
Curator

Record - 5 of 11 [TOP]

Compound ID	2127
Compound Structure
Plant Source	Mallotus philippensis (Linn.) Muell Arg. Common Name:Kamala Tree (English), Kampillaka, Kampilla, Karkash, Raktaanga, Rechan (Sanskrit)
Source Family	Euphorbiaceae
Origin	India
Plant Part Used	Leaf
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Radiometric assay using BACTEC 460 system
Positive Control Used (conc.)	Rifampin (0.5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, bronchitis, random screening, antihelmentic
PubMed ID [Source Literature]	21114505
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Shukla C, Bisht GR, Saikia D, Kumar S, Thakur RL.Detection of anti-tuberculosis activity in some folklore plants by radiometric BACTEC assay.Lett Appl Microbiol. 2011 Jan;52(1):33-40
Curator

Record - 6 of 11 [TOP]

Compound ID	2128
Compound Structure
Plant Source	Mallotus philippensis (Linn.) Muell Arg. Common Name:Kamala Tree (English), Kampillaka, Kampilla, Karkash, Raktaanga, Rechan (Sanskrit)
Source Family	Euphorbiaceae
Origin	India
Plant Part Used	Leaf
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Radiometric assay using BACTEC 460 system
Positive Control Used (conc.)	Rifampin (1 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, bronchitis, random screening, antihelmentic
PubMed ID [Source Literature]	21114505
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Shukla C, Bisht GR, Saikia D, Kumar S, Thakur RL.Detection of anti-tuberculosis activity in some folklore plants by radiometric BACTEC assay.Lett Appl Microbiol. 2011 Jan;52(1):33-40
Curator

Record - 7 of 11 [TOP]

Compound ID	3596
Compound Structure
Plant Source	Nectandra hihua (R. & P.) Rowher Common Name:
Source Family	Lauraceae
Origin	Peru
Plant Part Used	Bark
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27294)
Assay / Test Done	Radiometric assay using BACTEC 460 system
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	10 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information
PubMed ID [Source Literature]	13678239
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator	Rachana, vikramjitmandal

Record - 8 of 11 [TOP]

Compound ID

3111

Compound Structure

Plant Source

Euclea natalensis Common Name:

Source Family

Ebenaceae

Origin

Southern Africa

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Radiometric assay using BACTEC 460 system

Positive Control Used (conc.)

Ethambutol (1.25 µg/ml), Isoniazid (0.062 µg/ml), Rifampin (0.125 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

10 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Isodiospyrin

PubChem ID

99298

Ethnomedicinal Information

Antibacterial

PubMed ID [Source Literature]

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Quinone, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

374.079

Molecular Formula

C₂₂H₁₄O₆

SMILES

Oc1c(c2c3c(c(O)cc2C)C(=O)C=CC3=O)c(cc2c1C(=O)C=CC2=O)C

XLogP

0.964

PSA

108.740

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Antimycobacterial activity and possible mode of action of newly isolated neodiospyrin and other naphthoquinones from Euclea natalensis;South African Journal of Botany Volume 72, Issue 3, August 2006, Pages 349-352

Curator

Vsheeba, vikramjitmandal

Record - 9 of 11 [TOP]

Compound ID	3595
Compound Structure
Plant Source	Heisteria acuminata (Humb. & Bonpl.) Engler Common Name:
Source Family	Olacaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	Radiometric assay using BACTEC 460 system
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information
PubMed ID [Source Literature]	13678239
Extract Preparation
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator	Gppreetha, vikramjitmandal

Record - 10 of 11 [TOP]

Compound ID	3600
Compound Structure	N/A
Plant Source	Senna obliqua (G.Don) I. & B. Common Name:
Source Family	Loranthaceae
Origin	Peru
Plant Part Used	Stem, Fruit
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	Radiometric assay using BACTEC 460 system
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	90%
Activity [MIC] µg/ml	10 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information
PubMed ID [Source Literature]	13678239
Extract Preparation
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator	Rachana, vikramjitmandal

Record - 11 of 11 [TOP]

Compound ID	3601
Compound Structure
Plant Source	Senna silvestris (Vell.) I. & B. var. silvestris Common Name:
Source Family	Loranthaceae
Origin	Peru
Plant Part Used	Bark
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27294)
Assay / Test Done	Radiometric assay using BACTEC 460 system
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	Partial
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information
PubMed ID [Source Literature]	13678239
Extract Preparation
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator	Rachana, vikramjitmandal

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