BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 9 [TOP]

Compound ID	1426
Compound Structure
Plant Source	Chamaedora tepejilote Common Name:Pacaya Palm
Source Family	Arecaceae (Palmae)
Origin	Mexico
Plant Part Used	Leaf
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Radiorespirometric BACTEC Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, Pneumonia
PubMed ID [Source Literature]	16041726
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Jiménez A, Meckes M, Alvarez V, Torres J, Parra R. Secondary metabolites from Chamaedora tepejilote (Palmae) are active against Mycobacterium tuberculosis.Phytother Res. 2005 Apr;19(4):320-2
Curator

Record - 2 of 9 [TOP]

Compound ID	1427
Compound Structure
Plant Source	Chamaedora tepejilote Common Name:Pacaya Palm
Source Family	Arecaceae (Palmae)
Origin	Mexico
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Radiorespirometric BACTEC Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, Pneumonia
PubMed ID [Source Literature]	16041726
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Jiménez A, Meckes M, Alvarez V, Torres J, Parra R. Secondary metabolites from Chamaedora tepejilote (Palmae) are active against Mycobacterium tuberculosis.Phytother Res. 2005 Apr;19(4):320-2
Curator

Record - 3 of 9 [TOP]

Compound ID

1428

Compound Structure

Plant Source

Chamaedora tepejilote Common Name:Pacaya Palm

Source Family

Arecaceae (Palmae)

Origin

Mexico

Plant Part Used

Leaf

Extract

Hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Radiorespirometric BACTEC Assay

Positive Control Used (conc.)

Inhibition [%]

99 %

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Ursolic acid

PubChem ID

64945

Ethnomedicinal Information

Cough, Pneumonia

PubMed ID [Source Literature]

16041726

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Pentacyclic, Terpene, Triterpene, Acid, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

456.360

Molecular Formula

C₃₀H₄₈O₃

SMILES

O[C@@H]1C([C@H]2[C@@]([C@@H]3[C@]([C@]4(C(=CC3)[C@H]3[C@@](CC4)(CC[C@H]([C@@H]3C)C)C(=O)O)C)(CC2)C)(CC1)C)(C)C

XLogP

8.954

PSA

57.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Jiménez A, Meckes M, Alvarez V, Torres J, Parra R. Secondary metabolites from Chamaedora tepejilote (Palmae) are active against Mycobacterium tuberculosis.Phytother Res. 2005 Apr;19(4):320-2

Curator

Record - 4 of 9 [TOP]

Compound ID

1429

Compound Structure

Plant Source

Chamaedora tepejilote Common Name:Pacaya Palm

Source Family

Arecaceae (Palmae)

Origin

Mexico

Plant Part Used

Leaf

Extract

Hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Radiorespirometric BACTEC Assay

Positive Control Used (conc.)

Inhibition [%]

99 %

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Squalene

PubChem ID

638072

Ethnomedicinal Information

Cough, Pneumonia

PubMed ID [Source Literature]

16041726

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Alkene, Terpene, Triterpene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

410.391

Molecular Formula

C₃₀H₅₀

SMILES

C(C/C=C(/CCC=C(C)C)C)/C(=C/CC/C=C(/CC/C=C(/CCC=C(C)C)C)C)/C

XLogP

11.482

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Jiménez A, Meckes M, Alvarez V, Torres J, Parra R. Secondary metabolites from Chamaedora tepejilote (Palmae) are active against Mycobacterium tuberculosis.Phytother Res. 2005 Apr;19(4):320-2

Curator

Record - 5 of 9 [TOP]

Compound ID

1430

Compound Structure

Plant Source

Chamaedora tepejilote Common Name:Pacaya Palm

Source Family

Arecaceae (Palmae)

Origin

Mexico

Plant Part Used

Leaf

Extract

Hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Radiorespirometric BACTEC Assay

Positive Control Used (conc.)

Inhibition [%]

99 %

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Farnesol

PubChem ID

445070

Ethnomedicinal Information

Cough, Pneumonia

PubMed ID [Source Literature]

16041726

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Alkene, Terpene, Sesquiterpene, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

222.198

Molecular Formula

C₁₅H₂₆O

SMILES

OC/C=C(/CC/C=C(/CCC=C(C)C)C)C

XLogP

4.346

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Jiménez A, Meckes M, Alvarez V, Torres J, Parra R. Secondary metabolites from Chamaedora tepejilote (Palmae) are active against Mycobacterium tuberculosis.Phytother Res. 2005 Apr;19(4):320-2

Curator

Record - 6 of 9 [TOP]

Compound ID

2862

Compound Structure

Plant Source

Helichrysum aureonitens Common Name:Golden Everlasting

Source Family

Asteraceae (Compositae)

Origin

Africa

Plant Part Used

Callus tissue from young leaf

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 27264)

Assay / Test Done

Radiorespirometric BACTEC Assay

Positive Control Used (conc.)

Isoniazid (0.2 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

1000 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

4 - Chloro - 2 - (Hepta - 1, 3, 5 - Triyn - 1 - yl) - Phenol

PubChem ID

Ethnomedicinal Information

Anticancer activity, inhibition on DNA topoisomerase I

PubMed ID [Source Literature]

19881282

Extract Preparation

Cell suspension culture

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkyne, Phenol, Haloginated

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Against Vero and Human prostate epithelial carcinoma DU 145 cell lines

Molecular Weight

214.019

Molecular Formula

C₁₃H₇ClO

SMILES

C1(cc(c(cc1)O)C#CC#CC#CC)Cl

XLogP

3.971

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Ziaratnia SM, Ohyama K, Hussein AA, Muranaka T, Lall N, Kunert KJ, Meyer JJ.Isolation and identification of a novel chlorophenol from a cell suspension culture of Helichrysum aureonitens.Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1282-3

Curator

Gppreetha, keyamukherjee, reshmi

Record - 7 of 9 [TOP]

Compound ID

3399

Compound Structure

Plant Source

Melia volkensii Gurke Common Name:

Source Family

Meliaceae

Origin

Voi, Kenya

Plant Part Used

Seed

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 27 294)

Assay / Test Done

Radiorespirometric BACTEC Assay

Positive Control Used (conc.)

Inhibition [%]

99 %

Activity [MIC] µg/ml

16 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

12 β - Hydroxykulactone

PubChem ID

6476656

Ethnomedicinal Information

PubMed ID [Source Literature]

10217705

Extract Preparation

Crushed seeds (1 kg) were allowed to stand in 2 l of MeOH for 1 week

Chemical Classification [Active Compound]

Alicyclic, Pentacyclic, Steroid, Lactone, Ketone, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

468.324

Molecular Formula

C₃₀H₄₄O₄

SMILES

O1[C@@H]2[C@H]([C@]3([C@@](C4=CC[C@@H]5[C@@](C4C[C@H]3O)(CCC(=O)C5(C)C)C)(C2)C)C)[C@H](C1=O)C/C=C/C(C)C

XLogP

5.668

PSA

63.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cantrell CL, Rajab MS, Franzblau SG, Fischer NH.Antimycobacterial triterpenes from Melia volkensii.J Nat Prod. 1999 Apr;62(4):546-8

Curator

Vikramjitmandal

Record - 8 of 9 [TOP]

Compound ID

3400

Compound Structure

Plant Source

Melia volkensii Gurke Common Name:

Source Family

Meliaceae

Origin

Voi, Kenya

Plant Part Used

Seed

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 27 294)

Assay / Test Done

Radiorespirometric BACTEC Assay

Positive Control Used (conc.)

Inhibition [%]

99 %

Activity [MIC] µg/ml

16 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Kulonate

PubChem ID

490539

Ethnomedicinal Information

Used in folk medicine to alleviate pain - tea prepared from bark

PubMed ID [Source Literature]

10217705

Extract Preparation

Crushed seeds (1 kg) were allowed to stand in 2 l of MeOH for 1 week

Chemical Classification [Active Compound]

Alicyclic, Tetracyclic, Steroid, Ester, Ketone, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

526.366

Molecular Formula

C₃₃H₅₀O₅

SMILES

O1[C@@H]2[C@H]([C@]3([C@](C2)(C2=CC[C@@H]4[C@@](C2CC3)(CCC(=O)C4(C)C)C)C)C)[C@@H]([C@H]1O)[C@@H](CCC=C(C)C)C(=O)OC

XLogP

6.712

PSA

72.830

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cantrell CL, Rajab MS, Franzblau SG, Fischer NH.Antimycobacterial triterpenes from Melia volkensii.J Nat Prod. 1999 Apr;62(4):546-8

Curator

Vikramjitmandal

Record - 9 of 9 [TOP]

Compound ID

3401

Compound Structure

Plant Source

Melia volkensii Gurke Common Name:

Source Family

Meliaceae

Origin

Voi, Kenya

Plant Part Used

Seed

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 27 294)

Assay / Test Done

Radiorespirometric BACTEC Assay

Positive Control Used (conc.)

Inhibition [%]

99 %

Activity [MIC] µg/ml

4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

6β - Hydroxykulactone

PubChem ID

6476657

Ethnomedicinal Information

PubMed ID [Source Literature]

10217705

Extract Preparation

Crushed seeds (1 kg) were allowed to stand in 2 l of MeOH for 1 week

Chemical Classification [Active Compound]

Alicyclic, Pentacyclic, Steroid, Lactone, Ketone

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

468.324

Molecular Formula

C₃₀H₄₄O₄

SMILES

O1[C@@H]2[C@H]([C@]3([C@@](C4=C[C@@H](O)[C@@H]5[C@@](C4CC3)(CCC(=O)C5(C)C)C)(C2)C)C)[C@H](C1=O)C/C=C/C(C)C

XLogP

5.934

PSA

63.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cantrell CL, Rajab MS, Franzblau SG, Fischer NH.Antimycobacterial triterpenes from Melia volkensii.J Nat Prod. 1999 Apr;62(4):546-8

Curator

Rachana, vikramjitmandal

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