BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 2 Record - 1 of 49 [TOP]

Compound ID	1122
Compound Structure
Plant Source	Allium sativum L. Common Name:Garlic (English), Lashuna (Sanskrit)
Source Family	Amaryllidaceae
Origin	India, Africa, Malaysia
Plant Part Used	Bulb
Extract	Water
Target Bacteria	Mycobacterium tuberculosis H37Rv (Susceptible)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)	Isoniazid
Inhibition [%]	100 %
Activity [MIC] µg/ml	160 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma, expectorant, cough, pulmonary phthisis, consumption, chronic diseases of lungs, whooping cough, laryngeal tuberculosis
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 2 of 49 [TOP]

Compound ID	1123
Compound Structure
Plant Source	Allium sativum L. Common Name:Garlic (English), Lashuna (Sanskrit)
Source Family	Amaryllidaceae
Origin	India, Africa, Malaysia
Plant Part Used	Bulb
Extract	Water
Target Bacteria	Mycobacterium tuberculosis TRC - C1193 (Isoniazid resistant)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)	Isoniazid
Inhibition [%]	100 %
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma, expectorant, cough, pulmonary phthisis, consumption, chronic diseases of lungs, whooping cough, laryngeal tuberculosis
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 3 of 49 [TOP]

Compound ID	1169
Compound Structure
Plant Source	Ammi visnaga (L.) Lam. syn.aucus visnaga L. Common Name:Khella (English)
Source Family	Apiaceae (Umbelliferae)
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:40 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Kidney stones, renal colic, antispasmodic, vasodilators, random screening
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 4 of 49 [TOP]

Compound ID	1200
Compound Structure
Plant Source	Apium graveolens L. Common Name:Celery (English), Ajmodaa, Ajmoda, Ajmodikaa, Dipyaka (Sanskrit)
Source Family	Apiaceae (Umbelliferae)
Origin	India
Plant Part Used	N/A
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:40 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma, chest pain, cough, anthelmintic, antifungal, fever, urinary calculi, obesity, musculoskeletal disorder, dropsy, chronic diarrhoea
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) http://parisaramahiti.kar.nic.in/Medicinal_plants_new/med%20plants/p18.html
Curator

Record - 5 of 49 [TOP]

Compound ID	1205
Compound Structure
Plant Source	Areca catechu L. Common Name:Arecanut, Betel Nut (English), Puuga, Puugi, Kramuka, Ghontaa, Guwaak, Ghorant (Sanskrit)
Source Family	Arecaceae (Palmae)
Origin	India, Malaysia
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:40 dilutions
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, diuretic, digestive, small pox, dysentery, colic, cholera, leucorrhoea, random screening, cough and sore throat
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91 2) http://www.filipinoherbshealingwonders.filipinovegetarianrecipe.com/bunga.htm
Curator

Record - 6 of 49 [TOP]

Compound ID	1209
Compound Structure
Plant Source	Artemisia absinthium L. Common Name:Wormwood, Maderwood, Absinthe (English), Indhana, Damar (Sanskrit)
Source Family	Asteraceae (Compositae)
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Chronic fever, swellings, inflammation of liver, rheumatism, wounds, dandruff, vermifuge, random screening
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91
Curator

Record - 7 of 49 [TOP]

Compound ID	1289
Compound Structure
Plant Source	Brassica nigra (L.) Koch. Common Name:Black Mustard (English), Banarasi Raai, Raajika (Sanskrit)
Source Family	Brassicaceae
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:40 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, cough, sore throat
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91
Curator

Record - 8 of 49 [TOP]

Compound ID	1340
Compound Structure
Plant Source	Calotropis gigantea (L.) R. Br. ex Ait. Common Name:Madar (white-flowered), Giant Milk-weed (English), Alarka, Raajaarka, Shvetaarka (Sanskrit)
Source Family	Asclepiadaceae
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, asthma, expectorant, cough, asthma, leprosy
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 9 of 49 [TOP]

Compound ID

1354

Compound Structure

Plant Source

Canscora decussata Schult. Common Name:Daakuni, Sankhaapushpi, Dandotpala (Sanskrit)

Source Family

Gentaniaceae

Origin

India

Plant Part Used

Mother tinture

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Tube Dilution Test

Positive Control Used (conc.)

Streptomycin sulphate (0.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Mangiferin

PubChem ID

5281647

Ethnomedicinal Information

Tuberculosis, leprosy

PubMed ID [Source Literature]

807707, 565403

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Phenol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

422.085

Molecular Formula

C₁₉H₁₈O₁₁

SMILES

O1[C@H]([C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1c(O)c2c(oc3c(c2=O)cc(O)c(O)c3)cc1O

XLogP

-2.646

PSA

188.140

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Ghosal S, Chaudhuri RK.Chemical constituents of Gentianaceae XVI: antitubercular activity of xanthones of Canscora decussata Schult.J Pharm Sci. 1975 May;64(5):888-9

2) Ghosal S, Biswas K, Chaudhuri RK.Chemical constituents of Gentianaceae XXIV: Anti-Mycobacterium tuberculosis activity of naturally occurring xanthones and synthetic analogs.J Pharm Sci. 1978 May;67(5):721-2.

Curator

Record - 10 of 49 [TOP]

Compound ID

1355

Compound Structure

Plant Source

Canscora decussata Schult. Common Name:Daakuni, Sankhaapushpi, Dandotpala (Sanskrit)

Source Family

Gentaniaceae

Origin

India

Plant Part Used

Mother tinture

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Tube Dilution Test

Positive Control Used (conc.)

Streptomycin sulphate (0.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

10 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1,3,5-Trihydroxyxanthone

PubChem ID

25200626

Ethnomedicinal Information

Tuberculosis, leprosy

PubMed ID [Source Literature]

807707, 565403

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

243.029

Molecular Formula

C₁₃H₇O₅

SMILES

O1c2c(c(=O)c3c1c([O-])ccc3)c(O)cc(O)c2

XLogP

0.296

PSA

80.590

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 11 of 49 [TOP]

Compound ID

1356

Compound Structure

Plant Source

Canscora decussata Schult. Common Name:Daakuni, Sankhaapushpi, Dandotpala (Sanskrit)

Source Family

Gentaniaceae

Origin

India

Plant Part Used

Mother tinture

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Tube Dilution Test

Positive Control Used (conc.)

Streptomycin sulphate (0.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

10 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1, 3 - Dihydroxy - 5 - Methoxy - 9H - Xanthen - 9 - One

PubChem ID

12026489

Ethnomedicinal Information

Tuberculosis, leprosy

PubMed ID [Source Literature]

807707, 565403

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

258.053

Molecular Formula

C₁₄H₁₀O₅

SMILES

O1c2c(c(=O)c3c1cc(O)cc3O)cccc2OC

XLogP

0.815

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 12 of 49 [TOP]

Compound ID

1357

Compound Structure

Plant Source

Canscora decussata Schult. Common Name:Daakuni, Sankhaapushpi, Dandotpala (Sanskrit)

Source Family

Gentaniaceae

Origin

India

Plant Part Used

Mother tinture

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Tube Dilution Test

Positive Control Used (conc.)

Streptomycin sulphate (0.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

10 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - Hydroxy - 3, 5 - Dimethoxyxanthen - 9 - One

PubChem ID

5479773

Ethnomedicinal Information

Tuberculosis, leprosy

PubMed ID [Source Literature]

807707, 565403

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

272.068

Molecular Formula

C₁₅H₁₂O₅

SMILES

O1c2c(c(=O)c3c1c(OC)ccc3)c(O)cc(OC)c2

XLogP

1.334

PSA

55.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 13 of 49 [TOP]

Compound ID

1358

Compound Structure

Plant Source

Canscora decussata Schult. Common Name:Daakuni, Sankhaapushpi, Dandotpala (Sanskrit)

Source Family

Gentaniaceae

Origin

India

Plant Part Used

Mother tinture

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Tube Dilution Test

Positive Control Used (conc.)

Streptomycin sulphate (0.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

10 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1, 3, 5, 6 - Tetrahydroxyxanthen - 9 - One

PubChem ID

5479774

Ethnomedicinal Information

Tuberculosis, leprosy

PubMed ID [Source Literature]

807707, 565403

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

260.032

Molecular Formula

C₁₃H₈O₆

SMILES

O1c2c(c(=O)c3c1cc(O)cc3O)ccc(O)c2O

XLogP

-0.238

PSA

97.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 14 of 49 [TOP]

Compound ID

1359

Compound Structure

Plant Source

Canscora decussata Schult. Common Name:Daakuni, Sankhaapushpi, Dandotpala (Sanskrit)

Source Family

Gentaniaceae

Origin

India

Plant Part Used

Mother tinture

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Tube Dilution Test

Positive Control Used (conc.)

Streptomycin sulphate (0.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

10 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1, 3, 6 - Trihydroxy - 5 - Methoxyxanthen - 9 - One

PubChem ID

5493675

Ethnomedicinal Information

Tuberculosis, leprosy

PubMed ID [Source Literature]

807707, 565403

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

274.048

Molecular Formula

C₁₄H₁₀O₆

SMILES

O1c2c(c(=O)c3c1cc(O)cc3O)ccc(O)c2OC

XLogP

-0.148

PSA

86.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 15 of 49 [TOP]

Compound ID

1360

Compound Structure

Plant Source

Canscora decussata Schult. Common Name:Daakuni, Sankhaapushpi, Dandotpala (Sanskrit)

Source Family

Gentaniaceae

Origin

India

Plant Part Used

Mother tinture

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Tube Dilution Test

Positive Control Used (conc.)

Streptomycin sulphate (0.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

10 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1, 3, 5 - Trihydroxy - 6 - Methoxyxanthen - 9 - One

PubChem ID

5479775

Ethnomedicinal Information

Tuberculosis, leprosy

PubMed ID [Source Literature]

807707, 565403

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

274.048

Molecular Formula

C₁₄H₁₀O₆

SMILES

O1c2c(c(=O)c3c1cc(O)cc3O)ccc(OC)c2O

XLogP

-0.148

PSA

86.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 16 of 49 [TOP]

Compound ID

1361

Compound Structure

Plant Source

Canscora decussata Schult. Common Name:Daakuni, Sankhaapushpi, Dandotpala (Sanskrit)

Source Family

Gentaniaceae

Origin

India

Plant Part Used

Mother tinture

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Tube Dilution Test

Positive Control Used (conc.)

Streptomycin sulphate (0.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

10 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

3, 5 - Dimethoxy - 1, 6 - Dihydroxyxanthone

PubChem ID

5281630

Ethnomedicinal Information

Tuberculosis, leprosy

PubMed ID [Source Literature]

807707, 565403

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

288.063

Molecular Formula

C₁₅H₁₂O₆

SMILES

O1c2c(c(=O)c3c1cc(OC)cc3O)ccc(O)c2OC

XLogP

0.371

PSA

75.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 17 of 49 [TOP]

Compound ID

1362

Compound Structure

Plant Source

Canscora decussata Schult. Common Name:Daakuni, Sankhaapushpi, Dandotpala (Sanskrit)

Source Family

Gentaniaceae

Origin

India

Plant Part Used

Mother tinture

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Tube Dilution Test

Positive Control Used (conc.)

Streptomycin sulphate (0.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

10 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1, 3, 5, 6, 7 - Pentahydroxyxanthen - 9 - One

PubChem ID

10333643

Ethnomedicinal Information

Tuberculosis, leprosy

PubMed ID [Source Literature]

807707, 565403

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

276.027

Molecular Formula

C₁₃H₈O₇

SMILES

O1c2c(c(=O)c3c1cc(O)cc3O)cc(O)c(O)c2O

XLogP

-0.772

PSA

118.220

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 18 of 49 [TOP]

Compound ID

1363

Compound Structure

Plant Source

Canscora decussata Schult. Common Name:Daakuni, Sankhaapushpi, Dandotpala (Sanskrit)

Source Family

Gentaniaceae

Origin

India

Plant Part Used

Mother tinture

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Tube Dilution Test

Positive Control Used (conc.)

Streptomycin sulphate (0.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

10 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1, 6, 7 - Trihydroxy - 3, 5 - Dimethoxyxanthen - 9 - One

PubChem ID

5479777

Ethnomedicinal Information

Tuberculosis, leprosy

PubMed ID [Source Literature]

807707, 565403

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

304.058

Molecular Formula

C₁₅H₁₂O₇

SMILES

O1c2c(c(=O)c3c1cc(OC)cc3O)cc(O)c(O)c2OC

XLogP

-0.163

PSA

96.220

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 19 of 49 [TOP]

Compound ID

1364

Compound Structure

Plant Source

Canscora decussata Schult. Common Name:Daakuni, Sankhaapushpi, Dandotpala (Sanskrit)

Source Family

Gentaniaceae

Origin

India

Plant Part Used

Mother tinture

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Tube Dilution Test

Positive Control Used (conc.)

Streptomycin sulphate (0.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

10 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1, 7 - Dihydroxy - 3, 5, 6 - Trimethoxyxanthen - 9 - One

PubChem ID

5491588

Ethnomedicinal Information

Tuberculosis, leprosy

PubMed ID [Source Literature]

807707, 565403

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

318.074

Molecular Formula

C₁₆H₁₄O₇

SMILES

O1c2c(c(=O)c3c1cc(OC)cc3O)cc(O)c(OC)c2OC

XLogP

-0.073

PSA

85.220

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 20 of 49 [TOP]

Compound ID	1447
Compound Structure
Plant Source	Cicuta virosa L Common Name:Water Hemlock (English)
Source Family	Apiaceae (Umbelliferae)
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:40 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Spasmodic, random screening
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91 2) Anon., 1986. The Useful Plants of India. Council of Scientific and Industrial Research, New Delhi, India
Curator

Record - 21 of 49 [TOP]

Compound ID	1448
Compound Structure
Plant Source	Cinnamomum camphora (L.) Nees & Eberm Common Name:Camphor tree (English), Karpura, Ghanasaara, Chandra (Sanskrit)
Source Family	Lauraceae
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 and 1:1280 dilutions
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91 2) Sharma, S.K., 1998. Medicinal Plants Used in Ayurveda. National Academy of Ayurveda, Ministry of Health and Family Welfare, Govt. of India, New Delhi, India
Curator

Record - 22 of 49 [TOP]

Compound ID	1460
Compound Structure
Plant Source	Citrullus colocynthis Schrad. Common Name:Colocynth Bitter Apple (English), Indravaaruni, Indravalli (Sanskrit)
Source Family	Cucurbitaceae
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculous glands of neck, asthma, bronchitis, leprosy
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91 2) Sharma, S.K., 1998. Medicinal Plants Used in Ayurveda. National Academy of Ayurveda, Ministry of Health and Family Welfare, Govt. of India, New Delhi, India 3) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 23 of 49 [TOP]

Compound ID	1501
Compound Structure
Plant Source	Cocculus indicus Common Name: Indian Cockle (English)
Source Family	Menispermaceae
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:40 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	The allied species C. hirsutus Diels for tubercular glands and cough, random screening
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 24 of 49 [TOP]

Compound ID	1531
Compound Structure
Plant Source	Convolvulus arvensis L. Common Name:Deers Foot (English), Bhadrabalaa, Hiranpadi (Sanskrit)
Source Family	Convolvulaceae
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Fever, purgative, cathartic, random screening
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 25 of 49 [TOP]

Compound ID	1564
Compound Structure
Plant Source	Croton tiglium L. Common Name:Purging Croton (English), Jayapaala, Dravanti, Dantibija, Tintidiphala (Sanskrit)
Source Family	Euphorbiaceae
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, expectorant
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

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