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Compound ID2531
Compound Structure
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Plant SourceSalvia Africana-lutea     Common Name:Beach Salvia, Dune Salvia
Source FamilyLamiaceae
OriginAfrica
Plant Part Used
Extract
Target BacteriaMycobacterium aurum
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCarnosic acid
PubChem ID   65126
Ethnomedicinal InformationInfections, tuberculosis, fever
PubMed ID [Source Literature]17256988
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Diterpene, Acetoxy, Acid, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight332.199
Molecular FormulaC20H28O4
SMILESOC(=O)[C@@]12[C@H](C(CCC1)(C)C)CCc1c2c(O)c(O)c(c1)C(C)C
XLogP5.183
PSA77.760
H-bond Donor3
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) Hussein AA, Meyer JJ, Jimeno ML, Reodríguez B.Bioactive diterpenes from Orthosiphon labiatus and Salvia africana-luta.J Nat Prod. 2007 Feb;70(2):293-5

2) Seaman, T., 2005. The antimicrobial and antimycobacterial activity of plants used for the treatment of respiratory ailments in Southern Africa and the isolation of anacardic acid from Ozoroa paniculosa. M.Sc. Dissertation. University of the Witwatersrand, South Africa

Curator

                  Record - 2 of 4   [TOP]
Compound ID2532
Compound Structure
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Plant SourceSalvia Africana-lutea     Common Name:Beach Salvia, Dune Salvia
Source FamilyLamiaceae
OriginAfrica
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml9 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCarnosic acid
PubChem ID   65126
Ethnomedicinal InformationInfections, tuberculosis, fever
PubMed ID [Source Literature]17256988
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Diterpene, Acetoxy, Acid, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight332.199
Molecular FormulaC20H28O4
SMILESOC(=O)[C@@]12[C@H](C(CCC1)(C)C)CCc1c2c(O)c(O)c(c1)C(C)C
XLogP5.183
PSA77.760
H-bond Donor3
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) Hussein AA, Meyer JJ, Jimeno ML, Rodríguez B.Bioactive diterpenes from Orthosiphon labiatus and Salvia africana-lutea.J Nat Prod. 2007 Feb;70(2):293-5

Curator

                  Record - 3 of 4   [TOP]
Compound ID2533
Compound Structure
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Plant SourceSalvia Africana-lutea     Common Name:Beach Salvia, Dune Salvia
Source FamilyLamiaceae
OriginAfrica
Plant Part Used
Extract
Target BacteriaMycobacterium smegmatis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml8000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCarnosic acid
PubChem ID   65126
Ethnomedicinal InformationInfections, tuberculosis, fever
PubMed ID [Source Literature]17256988
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Diterpene, Acetoxy, Acid, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight332.199
Molecular FormulaC20H28O4
SMILESOC(=O)[C@@]12[C@H](C(CCC1)(C)C)CCc1c2c(O)c(O)c(c1)C(C)C
XLogP5.183
PSA77.760
H-bond Donor3
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) Hussein AA, Meyer JJ, Jimeno ML, Rodríguez B.Bioactive diterpenes from Orthosiphon labiatus and Salvia africana-lutea.J Nat Prod. 2007 Feb;70(2):293-5

2) Seaman, T., 2005. The antimicrobial and antimycobacterial activity of plants used for the treatment of respiratory ailments in Southern Africa and the isolation of anacardic acid from Ozoroa paniculosa. M.Sc. Dissertation. University of the Witwatersrand, South Africa

Curator

                  Record - 4 of 4   [TOP]
Compound ID3706
Compound Structure
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Plant SourceKaempferia marginata     Common Name:Tup Mup
Source FamilyZingiberaceae
OriginThailand
Plant Part UsedWhole plant
ExtractMethanol
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.1 µg/ml), Kanamycin (2.5 µg/ml), Rifampin (0.0023 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2α - Acetoxysandaracopimaradien - 1α - Ol
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]16309313
Extract PreparationThe dried and milled whole plant (619 g) was extracted three times (3 × 2 l) by maceration with MeOH at room temperature. After filtration and evaporation of the solvent under reduced pressure, the combined crude MeOH extract was partitioned between CH2Cl2 and H2O to afford CH2Cl2 (41 g) and H2O - MeOH (22.8 g) extracts. The CH2Cl2 - soluble extract was subjected to silica gel column chromatography to yield the fractions
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Diterpene, Acetoxy
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight302.225
Molecular FormulaC20H30O2
SMILESC1(=O)CCC([C@H]2[C@]1([C@@H]1C(=C[C@@](CC1)(C)C=C)C[C@H]2O)C)(C)C
XLogP4.441
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O2
No. of S0
Reference(s)1) Thongnest S, Mahidol C, Sutthivaiyakit S, Ruchirawat S.Oxygenated pimarane diterpenes from Kaempferia marginata.J Nat Prod. 2005 Nov;68(11):1632-6

CuratorGppreetha


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