BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 2 Record - 1 of 39 [TOP]

Compound ID

1493

Compound Structure

Plant Source

Clinacanthus siamensis Brem. Common Name:Sophaghni, Vishaghni, Vishalata (Sanskrit)

Source Family

Acanthaceae

Origin

Thailand

Plant Part Used

Fresh leaf

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.040 - 0.090 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Trans - 3 - Methylthioacrylamide

PubChem ID

11819072

Ethnomedicinal Information

Poison bites, inflammation, traumatic edema and swelling due to poison stings.

PubMed ID [Source Literature]

14646322

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Alkene, Amide, Thioether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

117.025

Molecular Formula

C₄H₇NOS

SMILES

S(/C=C/C(=O)N)C

XLogP

0.313

PSA

68.390

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Pootaeng-on Y, Pansa P, Srisanpang T, Taylor WC.Sulfur-containing compounds from Clinacanthus siamensis.Chem Pharm Bull (Tokyo). 2003 Dec;51(12):1423-5

2) http://ayurvedicmedicinalplants.com/index.php?option=com_zoom&Itemid=26&page=view&catid=3&key=63&hit=1

Curator

Record - 2 of 39 [TOP]

Compound ID

2379

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fruit

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.050 µg/ml), Kanamycin sulfate (2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Pellitorine

PubChem ID

5318516

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

15234750

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Alkene, Alkaloid, Amide

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

223.194

Molecular Formula

C₁₄H₂₅NO

SMILES

O=C(NCC(C)C)/C=C/C=C/CCCCC

XLogP

4.469

PSA

29.100

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Rukachaisirikul T, Siriwattanakit P, Sukcharoenphol K, Wongvein C, Ruttanaweang P, Wongwattanavuch P, Suksamrarn A.Chemical constituents and bioactivity of Piper sarmentosum.J Ethnopharmacol. 2004 Aug;93(2-3):173-6

Curator

Record - 3 of 39 [TOP]

Compound ID

2380

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fruit

Extract

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.050 µg/ml), Kanamycin sulfate (2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Guineensine

PubChem ID

6442405

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

15234750

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Amide, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

383.246

Molecular Formula

C₂₄H₃₃NO₃

SMILES

O1c2cc(/C=C/CCCCCC/C=C/C=C/C(=O)NCC(C)C)ccc2OC1

XLogP

7.275

PSA

47.560

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 4 of 39 [TOP]

Compound ID

2381

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fruit

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.050 µg/ml), Kanamycin sulfate (2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Brachyamide B

PubChem ID

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

15234750

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Alkaloid, Pyrrolidine, Amide

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

327.183

Molecular Formula

C₂₀H₂₅NO₃

SMILES

C1N(CCC1)C(=O)/C=C/CCCC/C=C/c1cc2c(cc1)OCO2

XLogP

5.013

PSA

38.770

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 5 of 39 [TOP]

Compound ID

2382

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fruit

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.050 µg/ml), Kanamycin sulfate (2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sarmentosine

PubChem ID

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

15234750

Extract Preparation

The pulverized, dried fruits of Piper sarmentosum (2.39 kg) were extracted successively with hexane and MeOH in a Soxhlet apparatus. After removal of solvent in vacuo, the hexane extract (70.7 g) was subjected to quick CC (silica gel) eluting with hexane, hexane–CHCl₃, CHCl₃, CHCl₃–MeOH and MeOH to give 6 main fractions

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Alkaloid, Pyrrolidine, Amide, Acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

299.152

Molecular Formula

C₁₈H₂₁NO₃

SMILES

C1c2c(ccc1/C=C/CC/C=C/C(=O)N1CCCC1)OCO2

XLogP

3.875

PSA

38.770

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 6 of 39 [TOP]

Compound ID

2386

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fresh root

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

N - [9 - (3, 4 - Methylenedioxyphenyl) - 2E, 4E, 8E - Nonatrienoyl] Pyrrolidine

PubChem ID

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

16462055

Extract Preparation

The fresh roots of Piper sarmentosum (481 g) were ground and extracted with 95 % EtOH at room temperature. After filtration and evaporation, the ethanolic extract was obtained as a brown viscous oil (19.4 g). The oil was partitioned between water (200 ml) and EtOAc (3 x 200 ml) and the water layer was further partitioned with n - BuOH (3 x 200 ml). Evaporation of the EtOAc-, n-BuOH- and water - soluble fractions gave a dark brown oil (6.3 g), a brown oil (1.8 g) and a light brown oil (10.5 g), respectively. The EtOAc - soluble fraction (6.3 g) was separated by flash column chromatography using silica gel

Chemical Classification [Active Compound]

Aromatic, Alkene, Phenylpropanoid, Pyrrolidine, Amide, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

325.168

Molecular Formula

C₂₀H₂₃NO₃

SMILES

C1c2c(ccc1/C=C/CC/C=C/C=C/C(=O)N1CCCC1)OCO2

XLogP

4.569

PSA

38.770

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

Record - 7 of 39 [TOP]

Compound ID

2387

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fresh root, fruit

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sarmentine

PubChem ID

6440616

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

16462055

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Alkene, Pyrrolidine, Amide, Alkaloid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

221.178

Molecular Formula

C₁₄H₂₃NO

SMILES

O=C(N1CCCC1)/C=C/C=C/CCCCC

XLogP

4.039

PSA

20.310

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

Record - 8 of 39 [TOP]

Compound ID

2388

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fresh Root

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Brachyamide B

PubChem ID

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Alkaloid, Pyrrolidine, Amide

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

327.183

Molecular Formula

C₂₀H₂₅NO₃

SMILES

C1N(CCC1)C(=O)/C=C/CCCC/C=C/c1cc2c(cc1)OCO2

XLogP

5.013

PSA

38.770

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

Record - 9 of 39 [TOP]

Compound ID

2389

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sarmentosine

PubChem ID

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Alkaloid, Pyrrolidine, Amide, Acid

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

N/A

Molecular Weight

299.152

Molecular Formula

C₁₈H₂₁NO₃

SMILES

C1c2c(ccc1/C=C/CC/C=C/C(=O)N1CCCC1)OCO2

XLogP

3.875

PSA

38.770

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

Record - 10 of 39 [TOP]

Compound ID

2390

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Pellitorine

PubChem ID

5318516

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Alkaloid, Amide

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

223.194

Molecular Formula

C₁₄H₂₅NO

SMILES

O=C(NCC(C)C)/C=C/C=C/CCCCC

XLogP

4.469

PSA

29.100

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

Record - 11 of 39 [TOP]

Compound ID

2963

Compound Structure

Plant Source

Haloxylon salicornicum Bunge ex Boiss Common Name:NR

Source Family

Chenopodiaceae

Origin

Pakistan, Egypt, Jordan, Palestine, Iran, Iraq and Kuwait (in unfertile areas)

Plant Part Used

Whole plant

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Micro Broth Dilution Method

Positive Control Used (conc.)

Isoniazid (0.02 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Haloxyline B

PubChem ID

11453345

Ethnomedicinal Information

PubMed ID [Source Literature]

20542692

Extract Preparation

Methanol extract further partitioned with water and hexane. The water layer was further extracted with chloroform and subjected to silica gel column chromatography

Chemical Classification [Active Compound]

Alicyclic, Alkene, Pyrrolidine, Amide, Alcohol, Alkaloid

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

435.371

Molecular Formula

C₂₇H₄₉NO₃

SMILES

O[C@@H]1CCCN(C1)C(=O)/C=CC=C/CCCCCCCCCCCCCCCCCO

XLogP

8.430

PSA

60.770

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bibi N, Tanoli SA, Farheen S, Afza N, Siddiqi S, Zhang Y, Kazmi SU, Malik A.In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum.Bioorg Med Chem Lett. 2010 Jul 15;20(14):4173-6

Curator

KeyaMukherjee, vsheeba

Record - 12 of 39 [TOP]

Compound ID

3298

Compound Structure

Plant Source

Euphorbia peplis L. Common Name:

Source Family

Euphorbiaceae

Origin

India, Northern Italy

Plant Part Used

Leaf, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Ciprofloxacin (0.125 – 0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 160 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - O - (β - D - Glucopyranosyl) - (2S, 3S, 4R, 8Z) - 2N - [(2R) - 2 - Hydroxytetracosenoil] - 8 (Z) - Octadecene - 1, 3, 4 - Triol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

14643323

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Cerebroside, Amide, Alcohol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

843.680

Molecular Formula

C₄₈H₉₃NO₁₀

SMILES

C(=O)(N[C@@H](CO[C@@H]1OC(C([C@H]([C@@H]1O)O)O)CO)[C@H](O)[C@@H](CCC/C=C/CCCCCCCCC)O)[C@H](O)CCCCCCCCCCCCCCCCCCCCCC

XLogP

14.906

PSA

189.170

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50

Curator

Vsheeba, vikramjitmandal

Record - 13 of 39 [TOP]

Compound ID

3299

Compound Structure

Plant Source

Euphorbia peplis L. Common Name:

Source Family

Euphorbiaceae

Origin

India, Northern Italy

Plant Part Used

Leaf, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Ciprofloxacin (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

40 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - O - (β - D - Glucopyranosyl) - (2S, 3S, 4R, 8Z) - 2N - [(2R) - 2 - Hydroxyhexacosenoil] - 8 (Z) - Octadecene - 1, 3, 4 - Triol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

14643323

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Cerebroside, Amide, Alcohol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

869.696

Molecular Formula

C₅₀H₉₅NO₁₀

SMILES

C(=O)(N[C@@H](CO[C@@H]1OC(C([C@H]([C@@H]1O)O)O)CO)[C@H](O)[C@@H](CCC/C=C/CCCCCCCCC)O)[C@H](O)CCCCCCCCCCCCCC/C=C/CCCCCCCC

XLogP

15.528

PSA

189.170

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50

Curator

Vsheeba, vikramjitmandal

Record - 14 of 39 [TOP]

Compound ID

3300

Compound Structure

Plant Source

Euphorbia peplis L. Common Name:

Source Family

Euphorbiaceae

Origin

India, Northern Italy

Plant Part Used

Leaf, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H242

Assay / Test Done

Positive Control Used (conc.)

Ciprofloxacin (0.125 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 160 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - O - (β - D - Glucopyranosyl) - (2S, 3S, 4R, 8Z) - 2N - [(2R) - 2 - Hydroxytetracosanoil] - 8 (Z) - Octadecene - 1, 3, 4 - Triol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

14643323

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Cerebroside, Amide, Alcohol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

843.680

Molecular Formula

C₄₈H₉₃NO₁₀

SMILES

C(=O)(N[C@@H](CO[C@@H]1OC(C([C@H]([C@@H]1O)O)O)CO)[C@H](O)[C@@H](CCC/C=C/CCCCCCCCC)O)[C@H](O)CCCCCCCCCCCCCCCCCCCCCC

XLogP

14.906

PSA

189.170

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50

Curator

Vsheeba, vikramjitmandal

Record - 15 of 39 [TOP]

Compound ID

3301

Compound Structure

Plant Source

Euphorbia peplis L. Common Name:

Source Family

Euphorbiaceae

Origin

India, Northern Italy

Plant Part Used

Leaf, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H172

Assay / Test Done

Positive Control Used (conc.)

Ciprofloxacin (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 160 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - O - (β - D - Glucopyranosyl) - (2S, 3S, 4E, 8E) - 2N - [(2R) - 2 - Hydroxyhexadecanoylamino] - 4 (E), 8 (E) - Octadecadiene - 1, 3 - Diol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

14643323

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Cerebroside, Amide, Alcohol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

713.544

Molecular Formula

C₄₀H₇₅NO₉

SMILES

C(=O)(N[C@@H](CO[C@@H]1OC(C([C@H]([C@@H]1O)O)O)CO)[C@H](O)/C=C/CCC/C=C/CCCCCCCC)[C@H](O)CCCCCCCCCCCCCC

XLogP

11.345

PSA

168.940

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50

Curator

Vsheeba, vikramjitmandal

Record - 16 of 39 [TOP]

Compound ID

3303

Compound Structure

Plant Source

Euphorbia peplis L. Common Name:

Source Family

Euphorbiaceae

Origin

India, Northern Italy

Plant Part Used

Leaf, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H331

Assay / Test Done

Positive Control Used (conc.)

Ciprofloxacin (0.125 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

40 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - O - (β - D - Glucopyranosyl) - (2S, 3S, 4R, 8Z) - 2N - [(2R) - 2 - Hydroxyhexacosenoil] - 8 (Z) - Octadecene - 1, 3, 4 - Triol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

14643323

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Cerebroside, Amide, Alcohol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

869.696

Molecular Formula

C₅₀H₉₅NO₁₀

SMILES

C(=O)(N[C@@H](CO[C@@H]1OC(C([C@H]([C@@H]1O)O)O)CO)[C@H](O)[C@@H](CCC/C=C/CCCCCCCCC)O)[C@H](O)CCCCCCCCCCCCCC/C=C/CCCCCCCC

XLogP

15.528

PSA

189.170

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50

Curator

Vsheeba, vikramjitmandal

Record - 17 of 39 [TOP]

Compound ID

3304

Compound Structure

Plant Source

Euphorbia peplis L. Common Name:

Source Family

Euphorbiaceae

Origin

India, Northern Italy

Plant Part Used

Leaf, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H242

Assay / Test Done

Positive Control Used (conc.)

Ciprofloxacin (0.125 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

80 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - O - (β - D - Glucopyranosyl) - (2S, 3S, 4R, 8Z) - 2N - [(2R) - 2 - Hydroxyhexacosenoil] - 8 (Z) - Octadecene - 1, 3, 4 - Triol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

14643323

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Cerebroside, Amide, Alcohol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

869.696

Molecular Formula

C₅₀H₉₅NO₁₀

SMILES

C(=O)(N[C@@H](CO[C@@H]1OC(C([C@H]([C@@H]1O)O)O)CO)[C@H](O)[C@@H](CCC/C=C/CCCCCCCCC)O)[C@H](O)CCCCCCCCCCCCCC/C=C/CCCCCCCC

XLogP

15.528

PSA

189.170

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50

Curator

Vsheeba, vikramjitmandal

Record - 18 of 39 [TOP]

Compound ID

3305

Compound Structure

Plant Source

Euphorbia peplis L. Common Name:

Source Family

Euphorbiaceae

Origin

India, Northern Italy

Plant Part Used

Leaf, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H172

Assay / Test Done

Positive Control Used (conc.)

Ciprofloxacin (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

40 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - O - (β - D - Glucopyranosyl) - (2S, 3S, 4R, 8Z) - 2N - [(2R) - 2 - Hydroxyhexacosenoil] - 8 (Z) - Octadecene - 1, 3, 4 - Triol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

14643323

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Cerebroside, Amide, Alcohol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

869.696

Molecular Formula

C₅₀H₉₅NO₁₀

SMILES

C(=O)(N[C@@H](CO[C@@H]1OC(C([C@H]([C@@H]1O)O)O)CO)[C@H](O)[C@@H](CCC/C=C/CCCCCCCCC)O)[C@H](O)CCCCCCCCCCCCCC/C=C/CCCCCCCC

XLogP

15.528

PSA

189.170

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50

Curator

Vsheeba, vikramjitmandal

Record - 19 of 39 [TOP]

Compound ID

3627

Compound Structure

Plant Source

Piper sanctum (Miq.) Schl. Common Name:

Source Family

Piperaceae

Origin

Southcentral region of Mexico

Plant Part Used

Leaf

Extract

Dichloromethane:Methanol (1:1)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cepharanone B

PubChem ID

162739

Ethnomedicinal Information

PubMed ID [Source Literature]

15620234

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Phenanthrene, Amide, Ether,

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Against Vero cells (ATCCCCL- 81) in the CellTiter 96 aqueous nonradioactive cell proliferation assay

Molecular Weight

279.090

Molecular Formula

C₁₇H₁₃NO₃

SMILES

O(c1c2c3c([nH]c(=O)c3cc1OC)cc1c2cccc1)C

XLogP

3.379

PSA

47.560

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Mata R, Morales I, Pérez O, Rivero-Cruz I, Acevedo L, Enriquez-Mendoza I, Bye R, Franzblau S, Timmermann B.Antimycobacterial compounds from Piper sanctum.J Nat Prod. 2004 Dec;67(12):1961-8

Curator

Rachana, Keyamukherjee, vikramjitmandal

Record - 20 of 39 [TOP]

Compound ID

3629

Compound Structure

Plant Source

Piper sanctum (Miq.) Schl. Common Name:

Source Family

Piperaceae

Origin

Southcentral region of Mexico

Plant Part Used

Stem

Extract

Dichloromethane:Methanol (1:1)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

128 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

N - Trans - Feruloyltyramine

PubChem ID

5280537

Ethnomedicinal Information

PubMed ID [Source Literature]

15620234

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Phenylpropanoid, Amide, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Against Vero cells (ATCCCCL- 81) in the CellTiter 96 aqueous nonradioactive cell proliferation assay

Molecular Weight

313.131

Molecular Formula

C₁₈H₁₉NO₄

SMILES

O(c1cc(/C=C/C(=O)NCCc2ccc(O)cc2)ccc1O)C

XLogP

2.691

PSA

78.790

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Mata R, Morales I, Pérez O, Rivero-Cruz I, Acevedo L, Enriquez-Mendoza I, Bye R, Franzblau S, Timmermann B.Antimycobacterial compounds from Piper sanctum.J Nat Prod. 2004 Dec;67(12):1961-8

Curator

Rachana, Keyamukherjee, vikramjitmandal

Record - 21 of 39 [TOP]

Compound ID

3630

Compound Structure

Plant Source

Piper sanctum (Miq.) Schl. Common Name:

Source Family

Piperaceae

Origin

Southcentral region of Mexico

Plant Part Used

Stem

Extract

Dichloromethane:Methanol (1:1)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

32 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

N-trans-(p-coumaroyl)tyramine

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

15620234

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Phenylpropanoid, Amide, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Against Vero cells (ATCCCCL- 81) in the CellTiter 96 aqueous nonradioactive cell proliferation assay

Molecular Weight

283.121

Molecular Formula

C₁₇H₁₇NO₃

SMILES

C1c(ccc(c1)/C=C/C(=O)NCCc1ccc(cc1)O)O

XLogP

3.346

PSA

69.560

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Mata R, Morales I, Pérez O, Rivero-Cruz I, Acevedo L, Enriquez-Mendoza I, Bye R, Franzblau S, Timmermann B.Antimycobacterial compounds from Piper sanctum.J Nat Prod. 2004 Dec;67(12):1961-8

Curator

Rachana, Keyamukherjee, vikramjitmandal

Record - 22 of 39 [TOP]

Compound ID

3634

Compound Structure

Plant Source

Piper sanctum (Miq.) Schl. Common Name:

Source Family

Piperaceae

Origin

Southcentral region of Mexico

Plant Part Used

Stem

Extract

Dichloromethane:Methanol (1:1)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Piperolactam A

PubChem ID

3081016

Ethnomedicinal Information

PubMed ID [Source Literature]

15620234

Extract Preparation

Leaves (1 kg) and stems (2.95 kg) of Piper sanctum were separately air - dried, ground and extracted by maceration with a mixture of CH₂Cl₂ - MeOH, 1:1 (12 l x 5, respectively), at room temperature. The extracts were concentrated in vacuo to yield 162.4 and 95 g of dry residues, respectively

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Phenanthrene, Amide, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

265.074

Molecular Formula

C₁₆H₁₁NO₃

SMILES

O(c1c(O)c2c3c([nH]c(=O)c3c1)cc1c2cccc1)C

XLogP

2.860

PSA

58.560

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Mata R, Morales I, Pérez O, Rivero-Cruz I, Acevedo L, Enriquez-Mendoza I, Bye R, Franzblau S, Timmermann B.Antimycobacterial compounds from Piper sanctum.J Nat Prod. 2004 Dec;67(12):1961-8

Curator

Rachana, Keyamukherjee, vikramjitmandal

Record - 23 of 39 [TOP]

Compound ID

3728

Compound Structure

Plant Source

Piper sarmentosum Common Name:Cha Plu

Source Family

Piperaceae

Origin

Thailand

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sarmentine

PubChem ID

6440616

Ethnomedicinal Information

Antimycobacterial and antiplasmodial activity, antifungal

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Alkene, Pyrrolidine, Amide, Alkaloid

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

221.178

Molecular Formula

C₁₄H₂₃NO

SMILES

O=C(N1CCCC1)/C=C/C=C/CCCCC

XLogP

4.039

PSA

20.310

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

KeyaMukherjee, rachanake

Record - 24 of 39 [TOP]

Compound ID

3729

Compound Structure

Plant Source

Piper sarmentosum Common Name:Cha Plu

Source Family

Piperaceae

Origin

Thailand

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

N - (3 - Phenylpropanoyl) Pyrrole

PubChem ID

11074385

Ethnomedicinal Information

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Phenylpropanoid, Pyrrol, Amide

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

199.100

Molecular Formula

C₁₃H₁₃NO

SMILES

O=C(n1cccc1)CCc1ccccc1

XLogP

4.579

PSA

22.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

KeyaMukherjee, gppreetha

Record - 25 of 39 [TOP]

Compound ID

3734

Compound Structure

Plant Source

Piper sarmentosum Common Name:Cha Plu

Source Family

Piperaceae

Origin

Thailand

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Guineensine

PubChem ID

6442405

Ethnomedicinal Information

Antimycobacterial and antiplasmodial activity, antifungal

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Amide, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

383.246

Molecular Formula

C₂₄H₃₃NO₃

SMILES

O1c2cc(/C=C/CCCCCC/C=C/C=C/C(=O)NCC(C)C)ccc2OC1

XLogP

7.275

PSA

47.560

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

KeyaMukherjee, rachanake

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